McLean M H, El-Omar E M. Genetics of gastric cancer[J]. Nat Rev Gastroenterol Hepatol, 2014, 11(11): 664-674. [2]Jemal A, Bray F, Center M M, et al. Global cancer statistics[J]. CA Cancer J Clin, 2011, 61(2): 69-90. [3]Duarte M C, Babeto E, Leite K R, et al. Expression of TERT in precancerous gastric lesions compared to gastric cancer[J]. Braz J Med Biol Res, 2011, 44(2): 100-104. [4]Shore D, Bianchi A. Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase[J]. EMBO J, 2009, 28(16): 2309-2322. [5]Ruiz-I-Altaba A, Sanchez P, Dahmane N. Gli and hedgehog in cancer: tumours, embryos and stem cells[J]. Nat Rev Cancer, 2002, 2(5): 361-372. [6]Ramalho-Santos M, Melton D A, McMahon A P. Hedgehog signals regulate multiple aspects of gastrointestinal development[J]. Development, 2000, 127(12): 2763-2772. [7]Stecca B, Ruiz-I-Altaba A.Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals[J]. J Mol Cell Biol, 2010, 2(2): 84-95. [8]Yang S M, Fang D C, Yang J L,et al. Effect of antisense human telomerase RNA on malignant phenotypes of gastric carcinoma[J]. J Gastroenterol Hepatol, 2002, 17(11): 1144-1152. [9]Lu M H, Deng J Q, Cao Y L, et al. Prognostic role of telomerase activity in gastric adenocarcinoma: A meta-analysis[J]. Exp Ther Med, 2012, 3(4): 728-734. [10]Chiang C, Litingtung Y, Lee E, et al. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function[J]. Nature, 1996, 383(6599): 407-413. [11]Dessaud E, McMahon A P, Briscoe J. Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network[J]. Development, 2008, 135(15): 2489-2503. [12]Evangelista M, Tian H, de-Sauvage F J. The hedgehog signaling pathway in cancer[J]. Clin Cancer Res, 2006, 12(20 Pt 1): 5924-5928. [13]Yoo Y A, Kang M H, Kim J S, et al. Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-beta-mediated activation of the ALK5-Smad 3 pathway[J]. Carcinogenesis, 2008, 29(3): 480-490. [14] Ke Z, Caiping S, Qing Z, et al. Sonic hedgehog-Gli1 signals promote epithelial-mesenchymal transition in ovarian cancer by mediating PI3K/AKT pathway[J]. Med Oncol, 2015, 32(1): 368. [15]Ohta H, Aoyagi K, Fukaya M, et al. Cross talk between hedgehog and epithelial-mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers[J]. Br J Cancer, 2009, 100(2): 389-398.
[2]
李阳,张丹,胡长江,等.hTERT调控Gli1的表达及其对胃癌细胞侵袭迁移的影响[J].第三军医大学学报,2015,37(23):2320. Li Yang,Zhang Dan,Hu Changjiang,et al.hTERT promotes migration and invasion of gastric cancer cells through transcriptional regulation of Gli1 expression[J].J Third Mil Med Univ,2015,37(09):2320.
