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心脏磁共振定量评价肥厚型心肌病患者的左室舒张功能

, PP. 563-567

Keywords: 肥厚型心肌病,心脏磁共振,左室心肌质量,左室峰值充盈率,左房大小

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Abstract:

目的应用心脏磁共振(cardiacmagneticresonance,CMR)定量评价肥厚型心肌病(hypertrophiccardiomyopathy,HCM)患者的左室舒张功能。方法纳入2013年10月至2014年8月于我科确诊为HCM的患者26例作为HCM组,其中男性15例,女性11例,年龄(43.54±13.29)岁。选取我院同期体检合格的健康志愿者28例作为对照组,其中男性16例,女性12例,年龄(41.52±11.87)岁。所有研究对象均行CMR检查获取心脏结构和功能参数,并进行对比分析。同时分析HCM组左室心肌质量(leftventricularmass,LVM)与左室峰值充盈率(leftventricularpeakfillingrate,LVPFR)和左房大小的相关性。其中左房大小参数包括左房前后径(leftatrialanteroposteriordiameter,LAAPD)、左房上下径(leftatrialsuperoinferiordiameter,LASID)和左房横径(leftatrialtransversediameter,LATD)。结果与对照组比较,HCM组LVM、室间隔厚度(interventricularseptalthickness,IVS)、LAAPD、LASID、LATD等参数明显增大(P<0.05),LVPFR明显减小(P<0.05),而左室收缩功能参数,如左室射血分数(leftventricularejectionfraction,LVEF)、左室峰值射血率(leftventricularpeakejectionrate,LVPER)等无明显差异(P>0.05)。相关性分析显示,HCM组LVM与LVPFR呈负相关(r=-0.509,P<0.05),LVM与LAAPD和LATD呈正相关(r=0.493,0.466,P<0.05),LVM与LASID没有明显的相关性(r=0.328,P>0.05)。结论HCM患者的左室舒张功能受损明显,CMR在定量评价HCM患者的左室舒张功能中起着重要作用。HCM患者的LVM与左室舒张功能指标(LVPFR、左房大小等)密切相关。

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