Rutherford M A,Pangrsic T. Molecular anatomy and physiology of exocytosis in sensory hair cells[J]. Cell Calcium,2012,52(3/4):327-337.？ [2]Ma C,Su L,Seven A B, et al. Reconstitution of the vital functions of Munc18 and Munc13 in neurotransmitter release[J]. Science,2013,339(6118):421-425.？ [3]Rizo J,Sudhof T C. The membrane fusion enigma:SNAREs,Sec1/Munc18 proteins,and their accomplices—guilty as charged?[J]. Annu Rev Cell Dev Biol,2012,28:279-308.？ [4]Uthaiah R C,Hudspeth A J. Molecular anatomy of the hair cell’s ribbon synapse[J]. J Neurosci,2010,30(37):12387-12399.？ [5]Safieddine S,Wenthold R J. SNARE complex at the ribbon synapses of cochlear hair cells:analysis of synaptic vesicle- and synaptic membrane-associated proteins[J]. Eur J Neurosci,1999,11(3):803-812.？ [6]Pangrsic T,Reisinger E,Moser T. Otoferlin:a multi-C2 domain protein essential for hearing[J]. Trends Neurosci,2012,35(11):671-680.？ [7]Nouvian R,Neef J,Bulankina A V, et al. Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins[J]. Nat Neurosci,2011,14(4):411-413.？ [8]Verhage M,Maia A S,Plomp J J, et al. Synaptic assembly of the brain in the absence of neurotransmitter secretion[J]. Science,2000,287(5454):864-869.？ [9]Uriguen L,Gil-Pisa I,Munarriz-Cuezva E, et al. Behavioral,neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice:relevance to schizophrenia[J]. Transl Psychiatry,2013,3:e221. [10]Vatta M,Tennison M B,Aylsworth A S, et al. A novel STXBP1 mutation causes focal seizures with neonatal onset[J]. J Child Neurol,2012,27(6):811-814.？ [11]Han G A,Malintan N T,Collins B M, et al. Munc18-1 as a key regulator of neurosecretion[J]. J Neurochem,2010,115(1):1-10. [12]Sheets L,Trapani J G,Mo W, et al. Ribeye is required for presynaptic Ca(V)1.3a channel localization and afferent innervation of sensory hair cells[J]. Development,2011,138(7):1309-1319.？ [13]Genc O,Kochubey O,Toonen R F, et al. Munc18-1 is a dynamically regulated PKC target during short-term enhancement of transmitter release[J]. Elife,2014,3:e01715.？ [14]Cijsouw T,Weber J P,Broeke J H, et al. Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner[J]. J Cell Biol,2014,204(5):759-775. ？
