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豚鼠延迟性和痕迹性眨眼条件反射消退的行为学特征

, PP. 310-314

Keywords: 条件反射,眨眼,消退,运动性记忆

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Abstract:

目的研究消退过程中豚鼠眨眼条件反应特征参数的变化规律。方法27只雄性12~16周龄豚鼠(体质量450~600g),按随机抽签法分为:①延迟性眨眼条件反射组(n=13);②痕迹性眨眼条件反射组(n=14)。使用2kHz的正弦波纯音和医用氧气流分别作为条件刺激和非条件刺激,配对训练豚鼠建立延迟性和痕迹性眨眼条件反射。而后单独给予纯音条件刺激,使豚鼠已经建立的眨眼条件反射消退。高精度张力换能器记录豚鼠左侧的眼轮匝肌活动,Matlab程序分析眨眼运动行为数据。结果与痕迹组比较,延迟组动物条件眨眼反应习得率和条件眨眼反应峰幅度均显著增高(P<0.05),但两组条件眨眼反应的消退速率没有显著区别(P>0.05)。此外,延迟组豚鼠反射消退较痕迹组自发恢复更明显(P<0.05)。结论延迟性和痕迹性眨眼条件反应的消退具有不同的行为学特征。

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