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糖尿病肾病肾组织TRAIL表达与肾小管间质损伤的关系

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Keywords: 糖尿病肾病,肿瘤坏死因子相关的凋亡诱导配体,肾小管间质损伤

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Abstract:

目的探讨肿瘤坏死因子相关的凋亡诱导配体(tumornecrosisfactorrelatedapoptosisinducingligand,TRAIL)在糖尿病肾病(diabeticnephropathy,DN)患者肾组织的表达以及与肾组织损伤之间的关系。方法选取2010-2013年本科收治的36例患有2型糖尿病经肾活检诊断为DN患者,9例肾错构瘤或肾癌切除术患者经病理检查为正常组织作为对照。收集各组患者人口学资料、临床数据,免疫组织化学检测肾组织TRAIL表达,并与临床数据及肾组织病理损伤进行相关性分析。结果DN患者TRAIL主要表达于肾小管上皮细胞细胞质和/或细胞膜,其表达水平随着肾小管间质损伤的加重而逐渐增加;与收缩压、尿蛋白定量、尿NAG、尿蛋白/尿肌酐、尿酸、尿素氮、血肌酐、胱抑素C呈正相关(P<0.05,P<0.01),与eGFR呈负相关(r=-0.936,P<0.01)。结论DN肾组织TRAIL表达与肾组织损伤程度及肾功能密切相关,提示TRAIL在DN疾病进展中具有重要作用。

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