Scully R,? Xie A. Double strand break repair functions of histone H2AX[J]. Mutat Res,? 2013, 750(1/2): 5-14.? [2]Wang L,? Dai W,? Lu L. Osmotic Stress-induced Phosphorylation of H2AX by Polo-like-Kinase 3 Affects Cell Cycle Progression in Human Corneal Epithelial Cells[J]. J Biol Chem,? 2014,? 289(43): 29827- 29835.? [3]Stiff T,? O’Driscoll M,? Rief N, et al. ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation[J]. Cancer Res,? 2004,? 64(7): 2390-2396.? [4]Di-Siena S,? Campolo F,? Rossi P, et al. UV and genotoxic stress induce ATR relocalization in mouse spermatocytes[J]. Int J Dev Biol,? 2013, 57(2/4): 281-287.? [5]An J,? Huang Y C,? Xu Q Z, et al. DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression[J]. BMC Mol Biol,? 2010,? 11: 18.? [6]Bonner W M,? Redon C E,? Dickey J S, et al. GammaH2AX and cancer[J]. Nat Rev Cancer,? 2008,? 8(12): 957-967.? [7]Koike M,? Sugasawa J,? Yasuda M, et al. Tissue-specific DNA-PK-dependent H2AX phosphorylation and gamma-H2AX elimination after X-irradiation in vivo[J]. Biochem Biophys Res Commun, 2008,? 376(1): 52-55. [8]Nakada S,? Yonamine R M,? Matsuo K. RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1[J]. Cancer Res,? 2012,? 72(19): 4974-4983.? [9]Akopiants K,? Mohapatra S,? Menon V, et al. Tracking the processing of damaged DNA double-strand break ends by ligation-mediated PCR:? increased persistence of 3′-phosphoglycolate termini in SCAN1 cells[J]. Nucleic Acids Res,? 2014,? 42(5): 3125-2137. [10]Nakamura A J,? Rao VA,? Pommier Y, et al. The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks[J]. Cell Cycle,? 2010, 9(2): 389-397.? [11]Peng Y,? Woods R G,? Beamish H, et al. Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM[J]. Cancer Res,? 2005,? 65(5): 1670-1677.