全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
大豆科学  2009 

豆豉对早期动脉粥样硬化大鼠主动脉平滑肌细胞凋亡的影响

DOI: 10.11861/j.issn.1000-9841.2009.01.0156, PP. 156-159

Keywords: 豆豉,动脉粥样硬化,细胞凋亡,增殖指数,突变型p,Fas

Full-Text   Cite this paper   Add to My Lib

Abstract:

观察豆豉对早期动脉粥样硬化大鼠主动脉平滑肌细胞凋亡及相关凋亡基因突变型p53和Fas蛋白表达的调节作用,以探讨其机制。采用高脂饲料喂养法建立大鼠早期动脉粥样硬化模型,同时连续10周灌胃给予豆豉提取物进行干预。末次给药后处死动物,光镜下观察血管平滑肌细胞的形态,透射电镜观察超微结构,采用流式细胞术检测细胞凋亡率以及凋亡相关基因突变型p53和Fas蛋白的表达。模型对照组主动脉平滑肌细胞的凋亡率及增值指数(FI)明显高于正常对照组(P<0.05),p53蛋白表达上调;豆豉干预组(20g生药kg-1、40g生药kg-1)大鼠主动脉平滑肌细胞的凋亡率明显高于模型对照组(P<0.05),增殖指数明显低于模型对照组(P<0.05),Fas蛋白表达上调(P<0.05),p53蛋白表达下调(P<0.05),光镜及透射电镜可见主动脉损伤明显较模型对照组改善。豆豉可调节早期动脉粥样硬化大鼠血管平滑肌细胞凋亡与增殖的平衡,其机制可能与调节突变型p53和Fas蛋白的表达有关。

References

[1]  王鑫国,葛喜珍,白霞,等.淡豆豉对去卵巢大鼠脂代谢的影响[J].中药材,2003,26(9):652-654.(Wang X G,Ge X Z,Bai X,et al.Effects of Semen Sojae Preparatum on lipid metabolism in ovariectomized rat[J].Journal of Chinese Medicinal Materials,2003,26(9):652-654.)
[2]  高淑丽,牛丽颍,曹秀莲,等.淡豆豉提取物抗心肌缺血作用的研究[J].河北医药,2007,29(9):923-924.(Gao S L,Niu L Y,Cao X L,et al.Protective effect of fermented soybean extraction on myocardial ischemia in mice[J].Hebei Medical Journal,2007,29(9):923-924.)
[3]  牛丽颖,刘娇,崔力剑,等.淡豆豉对早期动脉粥样硬化大鼠血管内皮损伤的保护作用[J].中药药理与临床,2007,23(5):923-924.(Niu L Y,Liu J,Cui L J,et al.Effects and mechanisms of semen sojae preparatum extracts on rat’s injury at the early stage of atherosclerosis[J].Pharmacology and Clinics of Chinese Materia Medica,2007,23(5):923-924.)
[4]  曹秀莲,牛丽颍,窦玉红,等.淡豆豉对心肌缺血小鼠心肌一氧化氮合酶表达的影响[J].河北中医药学报,2007,22(4):3-4.(Cao X L,Niu L Y,Dou L H,et al.Effects of Semen Sojae Preparatum on the NOS expression of myocardial ischemia in mice[J].Hebei Medical Journals,2007,22(4):3-4.)
[5]  白霞,牛丽颖,刘娇,等.淡豆豉防治早期动脉粥样硬化大鼠血管损伤的机制研究[J].时珍国医国药,2008,19(1):170-171.( Bai X,Niu L Y,Liu J,et al.Mechanisms of Semen Sojae Preparatum Extracts on Rat’s injury at the early stage of atherosclerosis[J].Lishizhen Medicine and Materia Medica Research,2008,19(1):170-171.)
[6]  王鑫国,郭秋红,白霞,等.乌鸡白凤丸对去卵巢大鼠雌激素分泌的影响[J].中成药,2003,25(1):67-68.( Wang X G,Guo Q H,Bai X.The effect of White Phoenix bolus of black-bone chicken on oestrogen level in ovariectomized Rat[J].Journal of Chinese Medicinal Materials,2003,25(1):67-68.)
[7]  国家药典委员会编.中华人民共和国药典(一部)[M].北京:化学工业出版社,2005:230.(Chinese Pharmacopoeia Committee.China pharmacopoeia version(part one )[M].Beijing:Chemical Industrial Press,2005:230.)
[8]  牛丽颖,杜红娜,刘姣,等.淡豆豉炮制前后异黄酮组分含量的比较研究[J].大豆科学,2008,27(4):672-674,678.( Niu L Y,Du H N,Liu J,et al.The comparative study on the content of isoflavone in Sojae Preparatum Extracts before and after processing[J].Soybean Science,2008,27(4):672-674,678.)?[9] Kockx M M,Knaapen M W.The role of apoptos is in vascular disease[J].Journal of Pathology,2000,190(3):267-280.
[9]  Han D K,Haudensch ild C C,Hong M K,et al.Evidence for apoptosis in human atherogenes is and in a rat vascular injury model[J].American Journal of Pathology,1995,147(2):267-277.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133