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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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手性伯胺催化剂用于顺式选择性的不对称Cross-Aldol反应
DOI: 10.1016/S1872-2067(10)60237-9, PP. 899-903
Keywords: 手性伯胺,有机催化,不对称催化,Cross-aldol反应
Abstract:
？基于酸碱作用,将手性伯胺与质子酸原位结合制得有机小分子催化剂,并用于醛与醛的不对称Cross-aldol反应.与一般手性仲胺催化剂不同,该类伯胺催化剂得到的是顺式选择性构型的Cross-aldol产物,其产率达90%,顺反比和ee值分别为9:1和90%.相比而言,采用简单易得的(1S,2S)-(+)-环己二胺即可得到较高选择性的顺式产物.
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