Adenofibroma of Skene's Duct: A Case Report

Skene's glands, also known as paraurethral glands, are homologues of the male prostate, in which painless cystic masses and inflammation due to obstruction have been rarely found and reported. In addition, there have been rare reported cases of adenocarcinoma of Skene's glands. Recently, the authors experienced the first case of adenofibroma arising in Skene's glands of a 62-year-old woman with coital pain. Hereby, we present the case with pathologic and immunohistochemical findings and a short review of literature. 1. Introduction Skene's glands and ducts are one of thirty normal duct structures in the female genital tract which were first introduced and described by Alexander Johnston Chalmers Skene in 1880. These have been thought to be homologues of the male prostate. A pair of glands is located posterolaterally to the urethra and opens its opening at the end of the urethra. Histologically, it is composed of glandular structures which are lined by pseudostratified columnar epithelium and ductal structures which are lined by either stratified squamous or transitional epithelium. Skene's glands secrete a small amount of mucoid material for sexual stimulation. A few kinds of diseases such as painless cystic mass and inflammation due to ductal obstruction were rarely documented [1–3]. In addition, there have been several case reports on adenocarcinoma arising from Skene’s glands [4]. Adenofibroma is a mixed biphasic tumor with glandular and fibrous proliferation. Most adenofibromas have been reported from ovary, breast, and uterine cervix. Rare cases of testicular and endometrial adenofibromas have been reported, but to the best of our knowledge, no cases have been reported from Skene’s glands. Recently, we experienced a case of adenofibroma arising in Skene's glands of a 62-year-old woman with coital pain. Hereby, we present the first such case of adenofibroma of Skene's glands with pathologic and immunohistochemical findings and a short review of literature. 2. Case Report A 62-year-old woman presented to our hospital with a red erythematous tumor in the external genitalia and coital pain. She had no specific past or family history and did not show any other abnormality except the tumor on physical examination. An excision on that lesion was performed with the clinical impression of urethral caruncle. Serum prostatic specific antigen (PSA) was not measured preoperatively. Grossly, the tumor was of a reddish tan ovoid mass, measuring ？cm, covered by pale tan mucosa with focal increased vascularity and showing gray white homogenous fibrotic cut surface.