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15%甲霜灵微胶囊缓释剂制备对烟草黑胫病的防治效果

, PP. 396-403

Keywords: 甲霜灵,微胶囊,性能表征,盆栽防效

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Abstract:

为明确15%甲霜灵微胶囊缓释剂配方及对烟草黑胫病的防治效果,采用原位聚合法制备并优化工艺,对获得的微胶囊进行释放规律研究及评价,并通过盆栽试验确定其防治效果.结果显示,微胶囊缓释剂最佳配方为(用质量分数表示):15%甲霜灵原药、27%二甲苯、2.5%农乳0203、2%氯化铵、4%乙二醇、0.2%黄原胶、2%NNO、47.3%水;制备优化工艺为:芯壁比例1:1、搅拌速度400r/min、调酸时间2h、pH4.5.所获得微胶囊制剂表面光滑致密无凹陷,大小均一,平均粒径12.93μm,包覆率93.58%.制剂有效成分在水相中缓慢释放,0~24h为初期释放阶段,符合一级动力学方程,R2为0.9115,累计释放量达29.52%;24~360h为匀速释放阶段,符合零级释放动力学方程,R2为0.9945,累计释放量为29.52%~93.22%;360h后趋于稳定.施用所制备的15%甲霜灵微胶囊21d后对烟草黑胫病的盆栽防治效果为82.2%,高于25%甲霜灵可湿性粉剂(75.7%).表明制备的15%甲霜灵微胶囊具有良好的缓释性,对烟草黑胫病有较好的防治效果.

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