Lwashina T. The structure and distribution of the flavonoids in plants[J]. J Plant Res, 2000,113:287.
[2]
Crepy V, Morand C, Besson C, et al.Quereetin ,but not its glycolsides, is absorption from the rat stomach [ J ]. J A gric Food Chem, 2002,50(3) :618.
[3]
Taiming L, Xuehuan J. Investation of the absorption mechanisms of baicalin and baicalein in rats[J]. J Pharm Sci, 2006,95(6) : 1326.
[4]
Wen X, WaUe T. Methylated flavonoids have greatly improved intestinal absorption and metabolic stability[J]. J Drug Metab Dispos, 2006,34(10) :1786.
[5]
Felgines C, Talavera S. Absorption and metabolism of red orang juice anthocyanins in rats[J]. Br J Nutr, 2006,95 (5) :898.
[6]
Wolffram S, Blockml, Ader P, et al. Quercetin 3-O-beta-glucoside is transported by the glucose carrier SGLT1 across the brush borderrnembrane of rat small intestine[J]. J Nutr, 2002, 132 (3) :630.
[7]
Wilkinson A P, Gee J M, Dupont M S, et al. Hydrolysis by lactaso phlorizin hydrolaso is the first step in the uptake of daidzein glucosides by rat small intestine in vitro [ J ]. J Xenobio-tica, 2003,33(3 ) :255.
[8]
Sesink A L, Arts I C, Faassen-Peters M, et al. Intestinal uptake of quercetin-3-glucoside in rats involves hydrolysis by lactase phlorizin hydrolase[J]. J Nutr, 2003,133(3) :773.
[9]
Jaganath I B, Mullen W, Edwards C A, et al. The relative contribution of the small and large intestine to the absorbtion and metabolism of mtin in man[J]. J Free Radic Res, 2006,40(10) : 1035.
[10]
Hong Cai, David J. Boocock, et al. Tissue distribution in mice and metabolism in murine and human liver of apigenin and tricin, flavones with putative cancer chemopreventive properties [ J ]. Cancer Chemother Pharmacol, 2007,60(2 ) :257.
Li y, Pan W S, Chen S L, et al. Pharmacokinetic, tissue distribution, and excretion of puererin and puerarin-phospholipid complex in rate[J]. J Drug Dev Ind Pharm, 2006,32(4) :413.
[14]
El Mohsen M A, Marks J, Kuhnle G, et al. Absorption,tissue distribution and excretion of pelargonidin and its metabolites following oral asministration to rats[J]. J Br J Nutr, 2006,95(1) : 51.
[15]
Graf B A, Ameho C, Dolnikowski G G, et al. Rat gastrointinal tissues metabolize quercetin[J]. J Nutr, 2006,136(1) :39.
[16]
Petri N, Tannergren C, Hoist B, et al. Absorption/metabolism of sulforaphane and quer-Cetin, and regulation of phase H enzymes, in human jejunum in vivo [ J ]. J Drug Metab Dispos, 2003,31(6) :805.
[17]
Nemeth K, Plumb G W, Benin J G, et al. Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans[J]. Eur J Nutr, 2003,42(1 ) :29.
[18]
Arts I C, Sesinka L, Faassen-Peters M, et al. The type ofsugar moiety is a major deter-minant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides [ J ]. Br J Nutr, 2004,91 (6) :841.
[19]
Chen X, Cui L,Duan X, et al. Pharmacokinetics and metabolism of the flavonoid scutellarin in humans after a single oral administration[J]. J Drug Metab Dispos, 2006,34(8) :1345.
[20]
Aura A M, Leary K A O, Williamson G, et al. Quercetinderivatives are deconjugated and converted to hydroxyphenylaceticacids but not methylated by human fecal flora in vitro[ J]. J Agric Food Chem, 2002,50(6) :1725.
[21]
YangXW HaoM HattoriM etal.Metabolite analysis for chemical constituents of traditional Chinese medicines[ M]. 11st ed[M].北京:中国医药科技出版社,2003.42.
[22]
Lin Y T, Hsiu S L, Hou Y C, et al. Degradation of flavonoid aglycones by rabbit, rat and human fecal flora[J]. J Biol Pharm Bull, 2003,26(5) :747.
[23]
Breinholt V M, Offord E A, Brouwer C, et al. In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids[ J]. J Food Chem Toxicol, 2002,40(5 ) :609.
[24]
Gradolatto A, Canyvenc-Lavier M C, Basly J P, et al. Metabolism of apigenin by liver phase Ⅰ and phase Ⅱ enzymes and byisolated perfused rat liver [ J ]. J Drug Metab Dispos, 2004,32(1):58.
