短舌紫菀化学成分及生物活性的研究

目的:对短舌紫菀Astersampsonii全草的化学成分进行研究。方法:以甲醇-石油醚-乙醚1∶1∶1提取,用氯仿进行萃取,对氯仿部位采用各种柱色谱进行分离纯化,通过波谱数据分析(MS,NMR,HMBC等)进行结构鉴定,并对部分化合物进行生物活性实验。结果:分离鉴定了10个化合物,分别为(4αR,4'αR,5S,5'S,9αR,9'αR)-4,4',4α,4'α,5,5',6,6',7,7',8,8'-dodecahydro-3,3',4α,4'α,5,5'-hexamethyl-2H,2'H-9α,9'α-binaphthofuran-2,2'-dione(1),furanoligularenone(2),(4αR,5S,8αR)-4α,5,6,7,8,8α-hexahydro-8α-hydroxy-3,4α,5-trimethylnaphthofuran-2(4H)-one(3),(4αR,5S,8αS)-4α,5,6,7,8,8α-hexahydro-8α-hydroxy-3,4α,5-trimethylnaphthofuran-2(4H)-one(4),methyl1'-hydroxy-2',6'-dimethoxy-4'-oxocyclohexanacetate(5),1'-hydroxy-2'-methoxy-4'-oxocyclohexanacetatemethyl(6),loliolide(7),jacaranone(8),β-谷甾醇(9),木栓酮(10),生物活性筛选结果表明化合物3对金黄色葡萄球菌有弱的抑制作用。结论:其中化合物1~8为首次从该属植物中分离得到。