Livak K J, Schmittgen T D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔCT ) method[J]. Methods, 2001,25:402.
[5]
马永兴,俞卓伟.现代衰老学[M].北京:科学技术文献出版社,2008:471.
[6]
Kayo Yasuda, Takamasa Ishii, Hitoshi Suda, et al. Age-related changes of mitochondrial structure and function in Caenorhabditis elegans[J]. Mech Ageing Dev, 2006,127:763.
[7]
Beckman K B, Ames B N. The free radical theory of aging matures[J].Physiology,1998, 78:547.
[8]
Harriet Gershon, David Gershon. Caenorhabditis elegans-a paradigm for aging research: Advantages and limitations[J]. Mech Ageing Dev, 2002,123: 261.
[9]
Vanfleteren J R, Braeckman B P. Mechanisms of life span determination in Caenorhabditis elegans[J]. Neurobiol Aging, 1999,20: 487.
[10]
Tsui D, van der Kooy D. Serotonin mediates a learned increase in attraction to high concentrations of benzaldehyde in aged Caenorhabditis elegans[J]. Learn Mem, 2008, 15(11):844.
[11]
Browner WS.The genetics of human longevity[J]. Am J Med, 2004, 117(11): 851.
[12]
Jason Z Morris,Heidi A Tissenbaum, Garry Ruvkun. A phosphotidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans[J]. Nature, 1996, 382: 536.
[13]
Pierce S B, Costa M, Wisotzkey R, et al. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family[J]. Gene Dev, 2001,15(6):672.
[14]
Tissenbaum H A, Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans[J]. Nature,2001,410: 227.
[15]
Yoko Honda, Shuji Honda. The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans[J]. FASEB J, 1999,13:1385.
[16]
Manoj Nanji, Neil A Hopper, David Gems. LET-60 RAS modulates effects of insulin/IGF-1 signaling on development and aging in Caenorhabditis elegans[J]. Aging Cell,2005,4: 235.
[17]
Masoro E J.Overview of caloric restriction and ageing[J]. Mech Aging Dev, 2005,126:913.
[18]
Yamei Wang, Heidi A Tissenbaum. Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO[J]. Mech Aging Dev,2006,127: 48.
[19]
Vellai T, Takacs-Vellai K, Zhang Y, et al. Genetics: Influence of TOR kinase on lifespan in C. elegans[J]. Nature, 2003, 426: 620.
[20]
Kailiang Jia, Di Chen, Donald L Riddle. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span[J]. Development,2004,131: 3897.