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肠道转运蛋白和代谢酶在中药有效成分胃肠处置中的作用研究进展

Keywords: 肠道转运蛋白,代谢酶,中药有效成分

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Abstract:

药物口服生物利用度决定于胃肠道吸收量,肠道转运蛋白和代谢酶是决定药物胃肠道吸收的重要因素,中药及其有效成分也表现出对药物代谢酶和转运蛋白的抑制或诱导作用。作者介绍了肠道转运蛋白和代谢酶在中药有效成分胃肠处置中的作用,以肠道转运蛋白和代谢酶为切入点,综述了中药有效成分的胃肠道吸收和代谢特征,指出开展中药活性成分在中药提取物及中药复方中吸收转运及代谢研究的重要性。

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