Yamada K, Ojika M, Ishigaki T, et al.Aplyronine A, a potent antitumor substance and the congeners aplyronines B and C isolated from the sea hare Aplysia kurodai [J]. J Am Chem Soc, 1993, 115(23): 11020.
[2]
Kigoshi H, Suenaga K, Mutou T, et al. Aplyronine A, a potent antitumor substance of marine origin, aplyronines B and C, and artificial analogues: total synthesis and structure-cytotoxicity relationships [J]. J Org Chem, 1996, 61(16): 5326.
[3]
Kisugi J, Ohye H, Kamiya H, et al. Biopolymers from marine invertebrates. X. Mode of action of an antibacterial glycoprotein, aplysianin E, from eggs of a sea hare, Aplysia kurodai [J]. Chem Pharm Bull, 1989, 37(11): 3050.
[4]
Kisugi J, Kamiya H, Yamazaki M. Purification and characterization of aplysianin E, an antitumor factor from sea hare eggs [J]. Cancer Res, 1987, 47(21): 5649.
[5]
Yamazaki M, Kimura K, Kisugi J, et al. Isolation and characterization of a novel cytolytic factor in purple fluid of the sea hare, Aplysia kurodai [J]. Cancer Res, 1989, 49(14): 3834.
[6]
Kigoshi H, Imamura Y, Yoshikawa K, et al. Three new cytotoxic alkaloids, aplaminone, neoaplaminone and neoaplaminone sulfate from the marine mollusc Aplysia kurodai[J]. Tetrahedron Lett, 1990, 31(34): 4911.
[7]
Tsukamoto S, Yamashita Y, Yoshida T, et al. Parguerol and isoparguerol isolated from the sea hare, Aplysia kurodai, induce neurite outgrowth in PC-12 cells [J]. Mar Drugs, 2004, 2(4): 170.
[8]
Tsukamoto S, Yamashita Y, Ohta T. New cytotoxic and antibacterial compounds isolated from the sea hare, Aplysia kurodai [J]. Mar Drugs, 2005, 3(2): 22.
[9]
Kusumi T, Uchida H, Inouye Y, et al. Novel cytotoxic monoterpenes having a halogenated tetrahydropyran from Aplysia kurodai [J]. J Org Chem, 1987, 52(20): 4597.
[10]
Miyamoto T, Higuchi R, Marubayashi N, et al. Studies on the constituents of marine opisthobranchia, IV. two new polyhalogenated monoterpenes from the sea hare Aplysia kurodai [J]. Liebigs Ann Chem, 1988, 1988(12): 1191.
[11]
Yamashitaa E, Matsunoa T. A new apocarotenoid from the sea hare Aplysia kurodai [J]. Comp Biochem Physiol B Comp Biochem, 1990, 96(3): 465.
[12]
Guruvayoorappan C, Kuttan G. β-carotene inhibits tumor-specific angiogenesis by altering the cytokine profile and inhibits the nuclear translocation of transcription factors in B16F-10 melanoma cells [J]. Integr Cancer Ther, 2007, 6(3): 258.
[13]
Nishino H, Toduda H, Satomi Y, et al. Nishino H, Toduda H, Satomi Y. Cancer prevention by carotenoids [J]. Pure Appl Chem, 1999, 71(12): 2273.
[14]
Sun Z, Yao H. The influence of di-acetylation of the hydroxyl groups on the anti-tumor-proliferation activity of lutein and zeaxanthin [J]. Asia Pac J Clin Nutr, 2007, 16(Suppl 1): 447.
[15]
Okuzumi J, Nishino H, Murakoshi M, et al. Inhibitory effects of fucoxanthin, a natural carotenoid, on N-myc expression and cell cycle progression in human malignant tumor cells [J]. Cancer Lett, 1990, 55(1): 75.
[16]
Yamazaki M, Kisugi J, Kamiya H. Biopolymers from marine invertebrates. XI. characterization of an antineoplastic glycoprotein, dolabellanin A, from the albumen gland of a sea hare, Dolabella auricularia [J]. Chem Pharm Bull(Tokyo), 1989, 37(12): 3343.
[17]
Kisugi, R Iijima, M Yamazaki. An antineoplastic protein from the body wall of sea hare, Dolabella auricularia [J]. Dev Comp Immunol, 1998, 22(1): 132 .
[18]
Kisugi1, H Kamiya, M Yamazaki. Purification of dolabellanin-C an antineoplastic glycoprotein in the body fluid of a sea hare, Dolabella auricularia [J]. Dev Comp Immunol, 1989, 13(1): 3.
[19]
Yamazaki M, Tansho S, Kisugi J, et al. Purification and characterization of a cytolytic protein from purple fluid of the sea hare, Dolabella auricularia [J]. Chem Pharm Bull(Tokyo), 1989, 37(8): 2179.
[20]
Pettit G R, Kamano Y, Fujii Y, et al. Marine animal biosynthetic constituents for cancer chemotherapy [J]. J Nat Prod, 1981, 44(4): 482.
[21]
Pettit G R, Kamano Y, Brown P, et al.Structure of the cyclic peptide dolastatin 3 from Dolabella auricularia [J]. J Am Chem Soc, 1982, 104(3): 905.
[22]
Pettit G R, Kamano Y, Herald C L, et al. The isolation and structure of a remarkable marine animal antineoplastic constituent: dolastatin 10 [J]. J Am Chem Soc, 1987, 109(22): 6883.
[23]
Pettit G R, Kamano Y, Kizu H, et al. Isolation and structure of the cell growth inhibitory depsipeptides dolastatins 11 and 12 [J]. Heterocycles, 1989, 28(2), 553.
[24]
Pettit G R, Kamano Y, Herald C L, et al. Antineoplastic agent. 174. Isolation and structure of the cytostatic depsipeptide dolastatin 13 from the sea hare Dolabella auricularia [J]. J Am Chem Soc, 1989, 111(13): 5015.
[25]
Pettit G R, Kamano Y, Heralda C L, et al. Isolation of dolastatins 10-15 from the marine mollusc Dolabelia auricularia [J]. Tetrahedron, 1993, 49(41): 9151.
[26]
Pettit G R, Kamano Y, Herald C L, et al. Antineoplastic agents. 190. Isolation and structure of the cyclodepsipeptide dolastatin 14 [J]. J Org Chem, 1990, 55(10): 2989.
[27]
Pettit G R, Kamano Y, Dufresne C, et al. Isolation and structure of the cytostatic linear depsipeptide dolastatin 15 [J]. J Org Chem, 1989, 54(26): 6005.
[28]
Bai R, Friedman S J, Pettit G R, et al. Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules [J]. Biochem Pharmacol, 1992, 43(12): 2637.
[29]
Pettit G R, Xu J P, Hogan F, et al. Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16 [J]. J Nat Prod, 1997, 60(8): 752.
[30]
Pettit G R, Xu J P, Hogan F, et al. Isolation and structure of dolastatin 17 [J]. Heterocycles, 1997, 47(1): 491.
[31]
Pettit G R, Hogan F, Herald D L. Synthesis and X-ray crystal structure of the Dolabella auricularia peptide dolastatin 18 [J]. J Org Chem, 2004, 69(12): 4019.
[32]
Pettit G R, Xu J P, Doubek D L, et al. Antineoplastic agents. 510. Isolation and structure of dolastatin 19 from the gulf of California sea hare Dolabella auricularia [J]. J Nat Prod, 2004, 67(8): 1252.
[33]
Pettit G R, Valley P. Dolastatins A and B cell growth inhibitory substances: US, 4486414 . 1984.
[34]
Sone H, Nemoto T, Ojika M, et al. Isolation, structure, and synthesis of dolastatin C, a new depsipeptide from the sea hare Dolabella auricularia [J]. Tetrahedron Lett, 1993, 34(52): 8445.
[35]
Kindler H L, Tothy P K, Wolff R, et al. Phase II trials of dolastatin-10 in advanced pancreaticobiliary cancers [J]. Invest New Drugs, 2005, 23(5): 489.
[36]
Riely G J, Gadgeel S, Rothman I, et al. A phase 2 study of TZT-1027, administered weekly to patients with advanced non-small cell lung cancer following treatment with platinum-based chemotherapy [J]. Lung Cancer, 2007, 55(2): 181.
Kamiya H, Muramoto K, Yamazaki M. Aplysianin A, an antibacterial and antineoplastic glycoprotein in the albumen gland of a sea hare, Aplysia kurodai [J]. Experientia, 1986, 42(9): 1065.
[45]
Sone H, Nemoto T, Ishiwata H, et al.Isolation, structure, and synthesis of dolastatin D, a cytotoxic cyclic depsipeptide from the sea gare Dolabella auricularia [J]. Tetrahedron Lett, 1993, 34(52): 8449.
[46]
Ojika M, Nemoto T, Nakamura M, et al. Dolastatin E, a new cyclic hexapeptide isolated from the sea hare Dolabella auricularia [J]. Tetrahedron Lett, 1995, 36(28): 5057.
[47]
Nakamura M, Shibata T, Nakane K, et al. Stereochemistry and total synthesis of dolastatin E [J]. Tetrahedron Lett, 1995, 36(28): 5059.
[48]
Mutou T, Kondo T, Ojika M, et al. Isolation and stereostructures of dolastatin G and nordolastatin G, cytotoxic 35-membered cyclodepsipeptides from the Japanese sea hare Dolabella auricularia [J]. J Org Chem, 1996, 61(18): 6340.
[49]
Sone H, Shibata T, Fujita T, et al. Dolastatin H and isodolastatin H, potent cytotoxic peptides from the sea hare Dolabella auricularia: isolation, stereostructures and synthesis [J]. J Am Chem Soc, 1996, 118(8): 1874.
[50]
Sone H, Kigoshi H, Yamada K. Isolation and stereostructure of dolastatin I, a cytotoxic cyclic hexapeptide from the Japanese sea hare Dolabella auricularia [J]. Terrahedron, 1997, 53(24): 8149.
[51]
Suenaga K, Mutou T, Shibata T, et al.Isolation and stereostructure of aurilide, a novel cyclodepsipeptide from the Japanese sea hare Dolabella auricularia [J]. Tetrahedron Lett, 1996, 37(37): 6771.
[52]
K Suenaga, T Mutou, T Shibata, et al. Aurilide, a cytotoxic depsipeptide from the sea hare Dolabella auricularia [J]. Tetrahedron, 2004, 60(38): 8509.
[53]
Ishiwata H, Nemoto T, Ojika M, et al. Isolation and stereostructure of doliculide, a cytotoxic cyclodepsipeptide from the Japanese sea hare Dolabella auricularia [J]. J Org Chem, 1994, 59(17): 4710.
[54]
Sone H, Kondo T, Kiryu M, et al. Dolabellin, a cytotoxic bisthiazole metabolite from the sea hare Dolabella auricularia: structural determination and synthesis [J]. J Org Chem, 1995, 60(15): 4774.
[55]
Ojika M, Nagoya T, Yamada K. Dolabelides A and B, cytotoxic 22-membered macrolides isolated from the sea hare Dolabella auricularia [J]. Tetrahedron Lett, 1995, 36(41): 7491.
[56]
Suenaga K, Nagoya T, Shibata T, et al. Dolabelides C and D, cytotoxic macrolides isolated from the sea hare Dolabella auricularia [J]. J Nat Prod, 1997, 60(2): 155.
[57]
Sone H, Kigoshi H, Yamada K. Aurisides A and B, cytotoxic macrolide glycosides from the Japanese sea hare Dolabella auricularia [J]. J Org Chem, 1996, 61(25): 8956.
[58]
Kigoshia H, Itohb T, Ogawab T, et al. Auriculol, a cytotoxic oxygenated squalene from the Japanese sea hare Dolabella auricularia: isolation, stereostructure, and synthesis [J]. Tetrahedron Lett, 2001, 42(42): 7461.
[59]
Suenaga K, Shibata T, Takada N, et al.Aurilol, a cytotoxic bromotriterpene isolated from the sea hare Dolabella auricularia [J]. J Nat Prod, 1998, 61(4): 515.
[60]
Suenaga K, Kigoshi H, Yamada K. Auripyrones A and B, cytotoxic polypropionates from the sea hare Dolabella auricularia [J]. Tetrahedron Lett, 1996, 37(29): 5151.
[61]
Zandi K, Farsangi M H, Nabipour I, et al. Isolation and purification of a novel anticancer 6 K daltons protein from Persian Gulf sea hare, Aplysia dactylomela [J]. Iranian South Med J, 2004, 6(2): 97.
[62]
Appleton D R, Babcock R C, Copp B R. Novel tryptophan-derived dipeptides and bioactive metabolites from the sea hare Aplysia dactylomela [J]. Tetrahedron, 2001, 57(51): 10181.
[63]
Hollenbeak K H, Schmitz F J. Marine natural products: deodactol, antineoplastic sesquiterpenoid from the sea hare Aplysia dactylomela [J]. Tetrahedron, 1979, 35(4): 541.
[64]
Wessels M, Knig G M, Wright A D. New natural product isolation and comparison of the secondary metabolite content of three distinct samples of the sea hare Aplysia dactylomela from Tenerife [J]. J Nat Prod, 2000, 63(7): 920.
[65]
Dias T, Brito I, Moujir L, et al. Cytotoxic sesquiterpenes from Aplysia dactylomela [J]. J Nat Prod, 2005, 68(11): 1677.
[66]
Shubina L K, Fedorov S N, Kalinovskiy A I, et al. Four new chamigrane sesquiterpenoids from the opistobranch mollusk Aplysia dactylomela [J]. Russ Chem Bull, 2007, 56(10): 2109.
[67]
Vera B, Rodríguez A D, Avilés E, et al. Aplysqualenols A and B: squalene-derived polyethers with antitumoral and antiviral activity from the Caribbean sea slug Aplysia dactylomela [J]. Eur J Org Chem, 2009(31): 5327.
[68]
Kamiya H, Muramoto K, Goto R, et al. Characterization of the antibacterial and antineoplastic glycoproteins in a sea hare Aplysia juliana [J]. Nippon Suisan Gakkaishi, 1988, 54(5): 773.
[69]
Kamiya H, Muramotoa K, Gotoa R, et al. Purification and characterization of an antibacterial and antineoplastic protein secretion of a sea hare, Aplysia juliana [J]. Toxicon, 1989, 27(12): 1269.
[70]
Pettit G R, Herald C L, Ode R H, et al. The isolation of loliolide from an Indian ocean opisthobranch mollusk [J]. J Nat Prod, 1980, 43(6): 752.
[71]
Elkhayat E S. Cytotoxic and antibacterial constituents from the roots of Sonchus oleraceus L. growing in Egypt [J]. Phcog Mag, 2009, 5(20): 324.
[72]
Gallimore W A, Paul J S. Malyngamides O and P from the sea hare Stylocheilus longicauda [J]. J Nat Prod, 2000, 63(10): 1422.
[73]
Gallimore W A, Galario D L, Lacy C, et al. Two complex proline esters from the sea hare Stylocheilus longicauda [J]. J Nat Prod, 2000, 63(7): 1022.
