Wang C J, Wang S W, Lin J K. Suppressive effect of geniposide on the hepatotoxicity and hepatic DNA binding of aflatoxin B1 in rats[J]. Cancer Lett, 1991, 60(2):95.
Asai A, Nakano T, Takahashi M, et al. Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and its glucuronide gonjugates inmice[J]. J Agr Food Chem, 2005,53:7302.
Kang J J, Wang H W, Liu T Y,et al. Modulation of cytochrome P-450-dependent monooxygenases, glutathione and glutathione S-transferase in rat liver by geniposide from gardenia jasminoides[J]. Food Chem Toxicol, 1997, 35(10/11): 957.
Wang S W, Lai C Y, Wang C J. Inhibitory effect of geniposide on aflatoxin B1-induced DNA repair synthesis in primary cultured rat hepatocytes[J]. Cancer Lett, 1992, 65(2):133.
Kuo W H, Chou F P, Young S C, et al. Geniposide activates GSH S-transferase by the induction of GST M1 and GST M2 subunits involving the transcription and phosphorylation of MEK-1 signaling in rat hepatocytes[J]. Toxicol Appl Pharmacol, 2005, 208(2):155.
[24]
Ma T T, Huang C, Zong G J,et al. Hepatoprotective effects of geniposide in a rat model of nonalcoholic steatohepatitis[J]. J Pharm Pharmacol,2011, 63(4):587.
Yamamoto M, Miura N, Ohtake N, et al. Genipin, a metabolite derived from the herbal medicine Inchin-ko-to, and suppression of Fas-induced lethal liver apoptosis in mice[J]. Gastroenterology, 2000, 118(2):380.
[27]
Iinuma Y, Kubota M, Yagi M, et al. Effects of the herbal medicine Inchinko-to on liver function in postoperative patients with biliary atresia-a pilot study[J]. J Pediatr Surg, 2003, 38(11):1607.
[28]
Kaiho T, Tsuchiya S, Yanagisawa S, et al. Effect of the herbal medicine Inchin-Ko-To for serum bilirubin in hepatectomized patients[J]. Hepatogastroenterology, 2008, 55(81):150.
[29]
Takeuchi S, Goto T, Mikami K, et al. Genipin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of TNF-α production[J]. Hepatol Res, 2005, 33(4):298.
[30]
Okada K, Shoda J, Kano M, et al. Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresisand Nrf2-mediated antioxidative action in rat livers[J]. Am J Physiol Gastrointest Liver Physiol, 2007, 292(5):G1450.
[31]
Shoda J, Miura T, Utsunomiya H, et al. Genipin enhances Mrp2 (Abcc2)- mediatedbile formation and organic anion transport in rat liver[J]. Hepatology, 2004, 39(1):167.
[32]
Ohwada S, Kobayashi I, Harasawa N, et al. Severe acute cholestatic hepatitis of unknown etiology successfully treated with the Chinese herbal medicine Inchinko-to (TJ-135)[J]. World J Gastroenterol, 2009, 15(23):2927.
[33]
Arai M, Yokosuka O, Fukai K, et al. A case of severe acute hepatitis of unknown etiology treated with the Chinese herbal medicine Inchinko-to [J]. Hepatol Res, 2004, 28(3):161.
[34]
Mase A, Makino B, Tsuchiya N, et al. Active ingredients of traditional Japanese (kampo) medicine, inchinkoto, in murine concanavalin A-induced hepatitis[J]. J Ethnopharmacol, 2010, 27(3):742.
[35]
Ohta Y, Kongo-Nishimura M, Hayashi T, et al. Effect of Oren-gedoku-to (Huanglian-Jie-Du-Tang) extract on disruption of hepatic antioxidant defense systems in rats treated with D-galactosamine[J]. J Ethnopharmacol, 2004, 94(2/3):323.
[36]
Wang H, Feng F, Zhuang B Y, et al. Evaluation of hepatoprotective effect of Zhi-Zi-Da-Huang decoction and its two fractions against acute alcohol-induced liver injury in rats[J]. J Ethnopharmacol, 2009, 126(2):273.
Yamano T, Tsujimoto Y, Noda T, et al. Hepatotoxicity of geniposide in rats[J]. Food Chem Toxicol, 1990, 28(7):515.
[45]
Sato S, Kitamura H, Chino M, et al. A 13-week oral dose subchronic toxicity study of gardenia yellow containing geniposide in rats[J]. Food Chem Toxicol, 2007, 45(8):1537.
[46]
Yamano T, Tsujimoto Y, Noda T, et al. Hepatotoxicity of gardenia yellow color in rats[J]. Toxicol Lett, 1988, 44(1/2):177.
