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细胞共培养技术在医药研究中的应用

Keywords: 细胞,共培养技术,中药复方

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Abstract:

细胞共培养由于能更好地模拟体内环境,便于更好的观察细胞与细胞、细胞与培养环境之间的相互作用以及探讨药物的作用机制和可能的作用靶点,填补了单层细胞培养与整体动物实验研究的鸿沟,近年来倍受医药领域的关注,成为药物研发、生物制药领域的研究热点。细胞共培养方法包括直接共培养和间接共培养,主要用于疾病病理基础、新型治疗手段以及药物活性筛选的研究。现有的细胞共培养技术主要用于单一药物的药效学研究,用于联合药物相互作用的研究甚少。中药复方之间协同配伍,减毒增效。细胞共培养技术符合中药多成分、多靶点的作用特点,这对于未来探讨中药联合用药对机体的作用及机制的研究具有一定参考价值,为中药及复方研究提供了一种新的手段。该文就细胞共培养技术的方法与运用进行了概述,并对该技术运用于中药及复方的研究进行了展望。

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