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BeWo细胞模型及其在胎盘转运机制研究中的应用

Keywords: BeWo细胞模型,胎盘屏障,转运体,转运机制,滋养层细胞

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Abstract:

妊娠期胎盘屏障调控了母儿间的物质交换,研究药物的胎盘转运机制对解析药物有效性、安全性和毒性具有重要意义。BeWo细胞来源于人绒毛膜癌细胞,可形成滋养层单层细胞,是有效评价营养物质和药物摄取、外排和转运的胎盘屏障体外模型,该文详细介绍了BeWo细胞模型的特点和建立方法,以及应用该模型在营养物质和药物转运机制的研究进展。

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