Fujiki H,Suganuma M,Okabe S,et al.Cancer inhibition by green tea[J].Mutat Res-Fund Mol M,1998,402(1/2): 307.
[2]
Sang S,Tian S,Meng X,et al.Theadibenzotropolone A,a new type pigment from enzymatic oxidation of (-)-epicatechin and (-)-epigallocatechin gallate and characterized from black tea using LC/MS/MS[J].Tetrahedron Lett,2002,43(40): 7129.
[3]
Valcic S,Muders A,Jacobsen N E,et al.Antioxidant chemistry of green tea catechins.Identification of products of the reaction of (-)-epigallocatechin gallate with peroxyl radicals[J].Chem Res Toxicol,1999,12(4): 382.
[4]
Lipinski C A,Lombardo F,Dominy B W,et al.Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings[J].Adv Drug Deliver Rev,1997,23(1/3): 3.
[5]
Kuzuhara T,Suganuma M,Fujiki H.Green tea catechin as a chemical chaperone in cancer prevention[J].Cancer Lett,2008,261(1): 12.
[6]
Xu Q,Yang C H,Liu Q,et al.Chemopreventive effect of epigallocatechin-3-gallate (EGCG) and folic acid on the N-methyl-N\'-nitro-N-nitrosoguanidine (MNNG)-induced gastrointestinal cancer in rat model[J].J Digest Dis,2011,12(3): 181.
[7]
Zheng J,Yang B,Huang T,et al.Green tea and black tea consumption and prostate cancer risk: an exploratory Meta-analysis of observational studies[J].Nutr Cancer,2011,63(5): 663.
[8]
Connors S K,Chornokur G,Kumar N B.New insights into the mechanisms of green tea catechins in the chemoprevention of prostate cancer[J].Nutr Cancer,2011,8(18):1.
[9]
Butler L M,Wu A H.Green and black tea in relation to gynecologic cancers[J].Mol Nutr Food Res,2011,55(6): 931.
[10]
Nagle C M,Olsen C M,Bain C J,et al.Tea consumption and risk of ovarian cancer[J].Cancer Cause Control,2010,21(9): 1485.
[11]
Lee U L,Choi S W.The chemopreventive properties and therapeutic modulation of green tea polyphenols in oral squamous cell carcinoma[J].Int Scholarly Res Network,2011(4):1.
[12]
Koh Y W,Choi E C,Kang S U,et al.Green tea (-)-epigallocatechin-3-gallate inhibits HGF-induced progression in oral cavity cancer through suppression of HGF/c-Met[J].J Nutr Biochem,2011,22(11): 1074.
[13]
Li N,Sun Z,Han C,et al.The chemopreventive effects of tea on human oral precancerous mucosa lesions[J].Proc Soc Exp Biol Med,1999,220(4): 218.
[14]
Kumar N,Titus Ernstoff L,Newcomb P A,et al.Tea consumption and risk of breast cancer[J].Cancer Epidem Biomar,2009,18(1): 341.
[15]
Shrubsole M J,Lu W,Chen Z,et al.Drinking green tea modestly reduces breast cancer risk[J].J Nutr,2009,139(2): 310.
[16]
Gao Y T,Mclaughlin J K,Blot W J,et al.Reduced risk of esophageal cancer associated with green tea consumption[J].J Natl Cancer I,1994,86(11): 855.
Zhang M,Holman C D A J,Huang J,et al.Green tea and the prevention of breast cancer: a case——control study in southeast China[J].Carcinogenesis,2007,28(5): 1074.
[19]
Sun C L,Yuan J M,Lee M J,et al.Urinary tea polyphenols in relation to gastric and esophageal cancers: a prospective study of men in shanghai,China[J].Carcinogenesis,2002,23(9): 1497.
[20]
Yuan J M,Gao Y T,Yang C S,et al.Urinary biomarkers of tea polyphenols and risk of colorectal cancer in the shanghai cohort study[J].Int J Cancer,2007,120(6): 1344.
[21]
Luo J,Gao Y T,Chow W H,et al.Urinary polyphenols and breast cancer risk: results from the Shanghai women\'s health study[J].Breast Cancer Res Trt,2010,120(3): 693.
[22]
Sasazuki S,Inoue M,Miura T,et al.Plasma tea polyphenols and gastric cancer risk: a case-control study nested in a large population-based prospective study in Japan[J].Cancer Epidem Biomar,2008,17(2): 343.
[23]
Wu A H,Yu M C,Tseng C C,et al.Green tea and risk of breast cancer in Asian Americans[J].Int J Cancer,2003,106(4): 574.
[24]
Wu A H,Tseng C C,Van Den Berg D,et al.Tea intake,COMT genotype,and breast cancer in Asian-American women[J].Cancer Res,2003,63(21): 7526.
[25]
Bonner M R,Rothman N,Mumford J L,et al.Green tea consumption,genetic susceptibility,PAH-rich smoky coal,and the risk of lung cancer[J].Mutat Res-Gen Tox En,2005,582(1/2): 53.
[26]
Lu G,Liao J,Yang G.Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine[J].Cancer Res,2006,66(23): 11494.
[27]
Li N,Chen X,Liao J,et al.Inhibition of 7,12-dimethylbenz anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin[J].Carcinogenesis,2002,23(8): 1307.
[28]
Wang Z Y,Wan L D,Lee M J,et al.Inhibition of N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in rats by green and black tea[J].Carcinogenesis,1995,16(9): 2143.
[29]
Yamane T,Takahashi T,Kuwata K,et al.Inhibition of N-methyl-N\'-nitro-N-nitrosoguanidine-induced carcinogenesis by (-)-epigallocatechin gallate in the rat glandular stomach[J].Cancer Res,1995,55(10): 2081.
[30]
Gupta S,Hastak K,Ahmad N,et al.Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols[J].P Natl A Sci India A,2001,98(18): 10350.
[31]
Liang Y C,Lin Shiau S Y,Chen C F,et al.Inhibition of cyclin-dependent kinases 2 and 4 activities as well as induction of cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (-)-epigallocatechin-3-gallate[J].J Cell Biochem,1999,75(1): 1.
Zhou F,Zhou H,Wang T,et al.Epigallocatechin-3-gallate inhibits proliferation and migration of human colon cancer SW620 cells in vitro[J].Acta Pharmacol Sin,2011(10):120.
[35]
Zhang D,Al-Hendy M,Richard-Davis G,et al.Green tea extract inhibits proliferation of uterine leiomyoma cells in vitro and in nude mice[J].Am J Obstet Gynecol,2010,202(3): 281.
[36]
赵洁,田庆伟.绿茶儿茶素抗癌作用机理的研究进展[J].中国食品添加剂,2004(2): 26.
[37]
Yang W H,Fong Y C,Lee C Y,et al.Epigallocatechin-3-gallate induces cell apoptosis of human chondrosarcoma cells through apoptosis signal-regulating kinase 1 pathway[J].J Cell Biochem,2011,112(6): 1601.
[38]
Yang G Y,Liao J,Kim K,et al.Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols[J].Carcinogenesis,1998,19(4): 611.
[39]
Senthil Kumaran V,Arulmathi K,Srividhya R,et al.Repletion of antioxidant status by EGCG and retardation of oxidative damage induced macromolecular anomalies in aged rats[J].Exp Gerontol,2008,43(3): 176.
[40]
Srividhya R,Jyothilakshmi V,Arulmathi K,et al.Attenuation of senescence-induced oxidative exacerbations in aged rat brain by (-)-epigallocatechin-3-gallate[J].Int J Dev Neurosci,2008,26(2): 217.
Hsu S P,Wu M S,Yang C C,et al.Chronic green tea extract supplementation reduces hemodialysis-enhanced production of hydrogen peroxide and hypochlorous acid,atherosclerotic factors,and proinflammatory cytokines[J].Am J Clin Nutr,2007,86(5): 1539.
[43]
Lebel M,Massip L,Garand C,et al.Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechin[J].Ann Ny Acad Sci,2010,1197(1): 40.
Lu N,Chen P,Yang Q,et al.Anti-and pro-oxidant effects of (+)-catechin on hemoglobin-induced protein oxidative damage[J].Toxicol in Vitro,2011,25(4):833.
[46]
Hakim I A,Harris R B,Brown S,et al.Effect of increased tea consumption on oxidative DNA damage among smokers: a randomized controlled study[J].J Nutr,2003,133(10): 3303.
[47]
Schwartz J L,Baker V,Larios E,et al.Molecular and cellular effects of green tea on oral cells of smokers: a pilot study[J].Mol Nutr Food Res,2005,49(1): 43.
[48]
Osada K,Takahashi M,Hoshina S,et al.Tea catechins inhibit cholesterol oxidation accompanying oxidation of low density lipoprotein in vitro[J].Comp Biochem Phys C,2001,128(2): 153.
[49]
Tachibana H,Koga K,Fujimura Y,et al.A receptor for green tea polyphenol EGCG[J].Nat Struct Mol Biol,2004(11):380.
Leone M,Zhai D,Sareth S,et al.Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins[J].Cancer Res,2003,63(23): 8118.
[52]
Ishii T,Mori T,Tanaka T,et al.Covalent modification of proteins by green tea polyphenol (-)-epigallocatechin-3-gallate through autoxidation[J].Free Radical Bio Med,2008,45(10): 1384.
Shammas M A,Neri P,Koley H,et al.Specific killing of multiple myeloma cells by (-)-epigallocatechin-3-gallate extracted from green tea: biologic activity and therapeutic implications[J].Blood,2006,108(8): 2804.
[55]
Lambert J D,Hong J,Yang G,et al.Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations[J].Am J Clin Nutr,2005,81(1): 284S.
[56]
Nishikawa T,Nakajima T,Moriguchi M,et al.A green tea polyphenol,epigalocatechin-3-gallate,induces apoptosis of human hepatocellular carcinoma,possibly through inhibition of Bcl-2 family proteins[J].J Hepatol,2006,44(6): 1074.
[57]
Ermakova S,Choi B Y,Choi H S,et al.The intermediate filament protein vimentin is a new target for epigallocatechin gallate[J].J Biol Chem,2005,280(17): 16882.
[58]
Mitsiades C S,Mitsiades N S,Mcmullan C J,et al.Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma,other hematologic malignancies,and solid tumors[J].Cancer Cell,2004,5(3): 221.
[59]
Shimizu M,Deguchi A,Hara Y,et al.EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells[J].Biochem Bioph Res Co,2005,334(3): 947.
[60]
Vittal R,Selvanayagam Z E,Sun Y,et al.Gene expression changes induced by green tea polyphenol (-)-epigallocatechin-3-gallate in human bronchial epithelial 21BES cells analyzed by DNA microarray[J].Mol Cancer Ther,2004,3(9): 1091.
[61]
Chung J Y,Park J O,Phyu H,et al.Mechanisms of inhibition of the ras-MAP kinase signaling pathway in 30.7 b ras 12 cells by tea polyphenols (-)-epigallocatechin-3-gallate and theaflavin-3,3\'digallate[J].Faseb J,2001,15(11): 2022.
[62]
Lu G,Liao J,Yang G,et al.Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine[J].Cancer Res,2006,66(23): 11494.
[63]
Lu L H,Lee S S,Huang H C.Epigallocatechin suppression of proliferation of vascular smooth muscle cells: correlation with c-jun and JNK[J].Brit J Pharmacol,1998,124(6): 1227.
[64]
Fang M Z,Wang Y,Ai N,et al.Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines[J].Cancer Res,2003,63(22): 7563.
[65]
Shin E S,Park J,Shin J M,et al.Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme[J].Bioorgan Med Chem,2008,16(7): 3580.
Ahn W S,Yoo J,Huh S W,et al.Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions[J].Eur J Cancer Prev,2003,12(5): 383.
[69]
Bettuzzi S,Brausi M,Rizzi F,et al.Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study[J].Cancer Res,2006,66(2): 1234.
[70]
Shimizu M,Fukutomi Y,Ninomiya M,et al.Green tea extracts for the prevention of metachronous colorectal adenomas: a pilot study[J].Cancer Epidem Biomar,2008,17(11): 3020.
[71]
Suzuki Y,Tsubono Y,Nakaya N,et al.Green tea and the risk of colorectal cancer: pooled analysis of two prospective studies in Japan[J].J epidemiol,2005,15(4): 118.
[72]
Inoue M,Sasazuki S,Wakai K,et al.Green tea consumption and gastric cancer in Japanese: a pooled analysis of six cohort studies[J].Gut,2009,58(10): 1323.
[73]
Simons C C J M,Hughes L A E,Arts I C W,et al.Dietary flavonol,flavone and catechin intake and risk of colorectal cancer in the netherlands cohort study[J].Int J Cancer,2009,125(12): 2945.
[74]
Tavani A,Pregnolato A,La Vecchia C,et al.Coffee and tea intake and risk of cancers of the colon and rectum: a study of 3 530 cases and 7 057 controls[J].Int J Cancer,1997,73(2): 193.
[75]
Ogunleye A A,Xue F,Michels K B.Green tea consumption and breast cancer risk or recurrence: a meta-analysis[J].Breast Cancer Res Tr,2010,119(2): 477.
[76]
Chen D,Wan S B,Yang H,et al.EGCG,green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment[J].Adv Clin Chem,2011,53: 155.
[77]
Adhami V M,Siddiqui I A,Ahmad N,et al.Oral consumption of green tea polyphenols inhibits insulin-like growth factor-I-induced signaling in an autochthonous mouse model of prostate cancer[J].Cancer Res,2004,64(23): 8715.
[78]
Masuda M,Wakasaki T,Toh S,et al.Chemoprevention of head and neck cancer by green tea extract: EGCG——the role of EGFR signaling and ″lipid raft″[J].J Clin Oncol,2011,54:148.
Hou Z,Sang S,You H,et al.Mechanism of action of (-)-epigallocatechin-3-gallate: auto-oxidation-dependent inactivation of epidermal growth factor receptor and direct effects on growth inhibition in human esophageal cancer KYSE 150 cells[J].Cancer Res,2005,65(17): 8049.
[81]
Liang Y C,Lin Shiau S Y,Chen C F,et al.Suppression of extracellular signals and cell proliferation through EGF receptor binding by (-)-epigallocatechin gallate in human A431 epidermoid carcinoma cells[J].J Cell Biochem,1997,67(1): 55.
[82]
Adachi S,Nagao T,Ingolfsson H I,et al.The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells[J].Cancer Res,2007,67(13): 6493.
[83]
Adachi S,Nagao T,To S,et al.(-)-Epigallocatechin gallate causes internalization of the epidermal growth factor receptor in human colon cancer cells[J].Carcinogenesis,2008,29(10): 1986.
[84]
Masuda M,Suzui M,Lim J T E,et al.Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR-related pathways of signal transduction[J].J Exp Therapeutics Oncol,2002,2(6): 350.
Bigelow R,Cardelli J A.The green tea catechins,(-)-epigallocatechin-3-gallate (EGCG) and (-)-epicatechin-3-gallate (ECG),inhibit HGF/Met signaling in immortalized and tumorigenic breast epithelial cells[J].Oncogene,2006,25(13): 1922.
[87]
袁俊华.表没食子儿茶素没食子酸酯对结肠癌的预防作用及其相关机制研究.济南: 山东大学,2007.
[88]
Sartippour M R,Shao Z M,Heber D,et al.Green tea inhibits vascular endothelial growth factor (VEGF) induction in human breast cancer cells[J].J Nutr,2002,132(8): 2307.
[89]
Rodriguez S K,Guo W,Liu L,et al.Green tea catechin,epigallocatechin-3-gallate,inhibits vascular endothelial growth factor angiogenic signaling by disrupting the formation of a receptor complex[J].Int J Cancer,2006,118(7): 1635.
[90]
Liao J,Yang G Y,Park E S,et al.Inhibition of lung carcinogenesis and effects on angiogenesis and apoptosis in A/J mice by oral administration of green tea[J].Nutr Cancer,2004,48(1): 44.
[91]
Zhu B H,Zhan W H,Li Z R.(-)-epigallocatechin-3-gallate inhibits growth of gastric cancer by reducing VEGF production and angiogenesis[J].World J Gastroenterol,2007,13(8): 1162.
[92]
Sukhthankar M,Yamaguchi K,Lee S H,et al.A green tea component suppresses posttranslational expression of basic fibroblast growth factor in colorectal cancer[J].Gastroenterology,2008,134(7): 1972.
Pin C.Preparation of epigallocatechin-3-O-gallate (EGCG) fatty acid ester as antioxidant: 中国,03116200.2003-10-15.
[98]
Utenovaa B T,Malterudb K E,Risea F.Antioxidant activity of O-protected derivatives of (-)-epigallocatechin-3-gallate: inhibition of soybean and rabbit 15-lipoxygenases[J].Arkivoc,2007,9: 6.
[99]
Matsubara K,Saito A,Tanaka A,et al.Epicatechin conjugated with fatty acid is a potent inhibitor of DNA polymerase and angiogenesis[J].Life Sci,2007,80(17): 1578.
[100]
Lam W H,Kazi A,Kuhn D J,et al.A potential prodrug for a green tea polyphenol proteasome inhibitor: evaluation of the peracetate ester of (-)-epigallocatechin gallate [J].Bioorg Med Cchem,2004,12(21): 5587.
[101]
Chan T H,Lam W H,Chow L M,et al.Epigallocatechin gallate derivatives for inhibiting proteasome: US,10/921332. 2006-07-10.
[102]
Kuhn D,Lam W H,Kazi A,et al.Synthetic peracetate tea polyphenols as potent proteasome inhibitors and apoptosis inducers in human cancer cells[J].Front Biosci,2005,10:1010.
[103]
Helen mckinley,mark Jamieson.Handbook of green tea and health research[M].New York:Nova Science Pubcishers,2009.
[104]
Landis-Piwowar K R,Kuhn D J,Wan S B,et al.Evaluation of proteasome-inhibitory and apoptosis-inducing potencies of novel (-)-EGCG analogs and their prodrugs.[J].Int J Mol Med,2005,15(4): 735.
[105]
Osanai K,Landis-Piwowar K R,Dou Q P,et al.A para-amino substituent on the D-ring of green tea polyphenol epigallocatechin-3-gallate as a novel proteasome inhibitor and cancer cell apoptosis inducer[J].Bioorg Med Chem,2007,15(15): 5076.
[106]
Osanai K,Huo C,Landis-Piwowar K R,et al.Synthesis of -epigallocatechin -3-O-(4-hydroxybenzoate),a novel catechin from Cistus salvifolius,and evaluation of its proteasome inhibitory activities[J].Tetrahedron,2007,63(32): 7565.
[107]
Yu Z,Qin X L,Gu Y Y,et al.Prodrugs of fluoro-substituted benzoates of EGC as tumor cellular proteasome inhibitors and apoptosis inducers[J].Int J Mol Sci,2008,9(6): 951.
[108]
Lin S F,Lin Y,Lin M.Synthesis and structureeactivity relationship of 3-O-acylated (-)-epigallocatechins as 5a-reductase inhibitors[J].Eur J Med Chem,2010(45): 6068.
[109]
Matsubara K,Saito A,Tanaka A,et al.Catechin conjugated with fatty acid inhibits DNA polymerase and angiogenesis[J].DNA Cell boil,2006,25(2): 95.
[110]
Kumagai A,Nagaoka Y,Obayashi T,et al.Tumor chemopreventive activity of 3-O-acylated (-)-epigallocatechins[J].Bioorgan Med chem,2003,11(23): 5143.
[111]
Park K D,Lee S G,Kim S U,et al.Anticancer activity of 3-O-acyl and alkyl-(-)-epicatechin derivatives[J].Bioorg Med Chem Lett,2004,14(20): 5189.
[112]
Park K D,Cho S J.Synthesis and antimicrobial activities of 3-O-alkyl analogues of (+)-catechin: improvement of stability and proposed action mechanism[J].Eur J Med Chem,2010,45(3): 1028.
[113]
Dutta S,Basak A,Dasgupta S.Synthesis and ribonuclease A inhibition activity of resorcinol and phloroglucinol derivatives of catechin and epicatechin: importance of hydroxyl groups[J]. Bioorg Med Chem,2010,18(17): 6538.
[114]
Tanaka T,Kusano R,Kouno I.Synthesis and antioxidant activity of novel amphipathic derivatives of tea polyphenol[J].Bioorg Med Chem Lett,1998,8(14): 1801.
[115]
Fudouji R,Tanaka T,Taguri T,et al.Coupling reactions of catechins with natural aldehydes and allyl alcohols and radical scavenging activities of the triglyceride-soluble products[J].J Agr Food Chem,2009,57(14): 6417.
[116]
Hsieh D S,Wang H,Tan S W,et al.The treatment of bladder cancer in a mouse model by epigallocatechin-3-gallate-gold nanoparticles[J].Biomaterials,2011,32(30):7633.
[117]
Siddiqui I A,Adhami V M,Bharali D J,et al.Introducing nanochemoprevention as a novel approach for cancer control: proof of principle with green tea polyphenol epigallocatechin-3-gallate[J]. Cancer Res,2009,69(5): 1712.