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信宜润楠的化学成分研究

Keywords: 信宜润楠,丁内酯,木脂素,萜类,抑制胃癌(BGC-823)和卵巢癌(A2780)人肿瘤细胞活性,抑制β-葡萄糖苷酸酶释放

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Abstract:

通过萃取、正相硅胶、SephadexLH-20、闪式柱色谱以及反相HPLC柱色谱等多种分离方法相结合,从信宜润楠乙醇提物中首次分离得到21个化合物;借助红外、质谱和核磁共振等波谱学分析方法鉴定了它们的结构,其中包括8个丁内酯类(1~8),8个木脂素类(9~16)和5个萜类化合物(17~21),化合物16是降七碳木脂烷类新天然产物。经体外活性筛选发现化合物5对胃癌(BGC-823)和卵巢癌(A2780)人肿瘤细胞株有选择性抑制活性,IC50分别为0.13×10-6,2.66×10-6mol·L-1;在1×10-5mol·L-1时,化合物8和9具有明显抑制PAF刺激大鼠多形核白细胞β-葡萄糖苷酸酶释放作用,抑制率分别为60.0%,54.2%。

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