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过量ROS/RNS引发的线粒体功能障碍与代谢性心血管病及中药介入

Keywords: 活性氧/活性氮,线粒体功能障碍,凋亡,动脉粥样硬化,中药

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Abstract:

代谢性心血管病是以机体糖类或脂质代谢紊乱为主要病因的一类心血管疾病,其中2型糖尿病又是典型的代谢性疾病,它不仅会使人产生胰岛素抵抗,更与动脉粥样硬化有关。由活性氧/活性氮产生的氧化应激是引起动脉粥样硬化的一个重要因素,而线粒体不仅是活性氧/活性氮的来源,更是其作用靶点,现有证据表明,线粒体功能障碍是导致心血管损伤的一种机制。文章从活性氧/氮所引发的线粒体功能障碍入手,介绍了二者过量后所激发的线粒体凋亡通路对动脉粥样硬化的影响,就二者通过影响脂质代谢及诱发2型糖尿病,继而产生心血管疾病做一综述,并介绍了麦冬、紫铆亭、人参、葛根和白毛藤等数味中药通过抗ROS/RNS及影响线粒体凋亡通路,从而达到治疗作用。而且以上诸味中药还有诸如抗癌和抗疲劳等作用,有别于经典西药作用的单一性,显示了中药作用的多面性。

References

[1]  Giardino I, Edelstein D, Brownlee M. Bcl-2 expression on antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation end products in bovine endothelial cells[J]. J Clin Invert, 1996,97(6):1422.
[2]  Nishikawa T, Edelstein D, Du X L, et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage[J]. Nature, 2000,404(6779):787.
[3]  Cooper S A, Whaley-Connell A, Habibi J,et al. Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance[J]. Am J physiol Heart Circ Physiol, 2007, 293(4):H2009.
[4]  Nishio Y, Kanazawa A, Nagai Y, et al. Regulation and role of the mitochondrial transcription factor in the diabetic rat heart[J]. Ann NY Acad Sci, 2004,1011:78.
[5]  Mikaelian N P, Khalilov E M, Ivanov A S,et al. Mitochondrial enzymes in circulating lymphocytes during hemosorption for experimental hypercholesterolemia[J]. Biull Eksp Biol Med, 1983,96(9):35.
[6]  Knight-Lozano C A, Young C G, Burow D L,et al. Cigarette smoke exposure and hypercholesterolemia increase mitochondrial damage in cardiovascular tissues[J]. Circulation, 2002, 105(7): 849.
[7]  Yao P M, Tabas I. Free cholesterol loading of macrophages is associated with wide spread mitochondrial dysfunction and activation of the mitochondrial apoptosis pathway[J]. J Biol Chem, 2001, 276(45):42468.
[8]  McGavock J M, Lingvay I, Zib I,et al. Cardiac steatosis in diabetes mellitus:a 1H-magnetic resonance spectroscopy study[J]. Circulation, 2007,116(10):1170.
[9]  Kim J A, Montagnani M, Koh K K,et al. Reciprocal relationships between insulin resistance and endothelial dysfunction:molecular and pathophysiological mechanisms[J]. Circulation, 2006,113(15):1888.
[10]  Davidson S M, Duchen M R. Endothelial mitochondrial:contributing to vascular function and disease[J]. Circ Res, 2007, 100(8):1128.
[11]  Edith Lubos, Diane E Handy, Joseph Loscalzo. Role of oxidative stress and nitric oxide in atherothrombosis[J]. Front Biosci, 2008, 13:5323.
[12]  Lacza Z, Puskar M, Figueroa J P, et al. Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia[J]. Free Radic Biol Med, 2001,31(12):1609.
[13]  Ghafourifar P, Cadenas E. Mitochondrial nitric oxide synthase[J]. Trends Pharmacol Sci, 2005, 26(4):190.
[14]  Poderoso J J. The formation of peroxynitrite in the applied physiology of mitochondrial nitric oxide[J]. Arch Biochem Biophys, 2009, 484(2):214.
[15]  Qian J, Jiang F, Wang B,et al. Ophiopogonin D prevents H2O2-induced injury in primary human umbilical vein endothelial cells[J]. Ethnopharmacol,2010,128(2):438.
[16]  Zhang R, Kang K A, Piao M J,et al. Butin reduces oxidative stress-induced mitochondrial dysfunction via scavenging of reactive oxygen species[J]. Food Chem Toxicol, 2010, 48(3):922.
[17]  兰菲菲,刘誉,陈万群,等. 白毛藤提取物对肝癌SMMC-7721细胞增殖及C-myc基因表达的抑制作用[J]. 广东医学,2006,27(12): 1179.
[18]  Magdalena L Circu, Tak Yee Aw. Reactive oxygen species, cellular redox systems, and apoptosis[J]. Free Radic Biol Med,2010,48(6):749.
[19]  Lee J Y, Jung G Y, Heo H J, et al. 4-Hydroxynonenal induces vascular smooth muscle cell apoptosis through mitochondrial generation of reactive oxygen species[J]. Toxical Lett,2006,166:212.
[20]  Geng Y J, Libby P. Progression of atheroma:a struggle between death and procreation [J]. Arterioscler Thromb Vasc Biol,2002,22(9):1370.
[21]  Radi R, Cassina A, Hodara R. Nitric oxide and peroxynitrite interactions with mitochondria[J]. J Biol Chem,2002,383(3/4):401.
[22]  Ballinger S W. Mithondrial dysfunction in cardiovascular disease[J]. Free Radic Biol Med, 2005, 38(10):1278.
[23]  Madamanchi N R, Runge M S. Mithondrial dysfunction atherosclersis[J]. Circ Res, 2007,100(4):460.
[24]  Stump C S, Short K R, Bigelow M L, et al. Effect insulin on human sleletal muscle mitochondrial ATP production,protein synthesis,and mRNA transcripts[J]. Proc Natl Acad Sci USA, 2003, 100(13):7996.
[25]  Petersen K F, Befroy D, Dufour S,et al. Mitochondrial dysfunction in the elderly: possible role in insulin resistance[J]. Science, 2003, 300(5622):1140.
[26]  Cheng J, Cui R, Chen C H,et al. Oxidized low-density lipoprotein stimulates p53-dependent activation of proapoptotic Bax leading to apoptosis of differentiated endothelial progenitor cells[J]. Endocrinology, 2007,148(5):2085.
[27]  Fleming I, Mohamed A, Galle J,et al. Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKC alpha[J]. Cardiovasc Res, 2005,65(4):897.
[28]  Shiojima I, Yefremashvili M, Luo Z,et al. Akt signaling mediates postnatal heart growth in response to insulin and nutritional status[J]. J Biol Chem,2002,277(40):37670.
[29]  Yun S N, Moon S J, Ko S K,et al. Wild ginseng prevents the onset of high-fat diet induced hyperglycemia and obesity in ICR mice[J]. Arch Pharm Res, 2004,27(7):790.
[30]  Kim S H, Park K S. Effects of Panax ginseng extract on lipid metabolism in humans[J]. Pharmacol Res, 2003,48(5):511.
[31]  Luo J Z, Luo L. American ginseng stimulates insulin production and prevents apoptosis through regulation of uncoupling protein-2 in cultured beta cells[J]. Evid Based Complement Alternat Med,2006,3(3):365.
[32]  Kim H Y, Kim K. Protective effect of ginseng on cytokine-induced apoptosis in pancreatic beta-cells[J]. J Agric Food Chem,2007,55(8):2816.
[33]  Yin J, Gao Z, Liu D, et al. Berberine improves glucose metabolism through induction of glycolysis[J]. Am J Physiol Endocrinol Metab,2008,294(1):E148.
[34]  Yan L P, Chan S W, Chan A S,et al. Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats[J]. Life Sci, 2006, 79(4):324.
[35]  Dong Mei Chen,Liang Xiao,Xin Cai,et al. Involvement of multitargets in paeoniflorin-induced preconditioning[J]. J Pharmacol Exp Ther,2006,319(1):165.
[36]  Heo S K, Yun H J, Yi H S, et al. Evodiamine and rutaecarpine inhibit migration by LIGHT via suppression of NADPH oxidase activation[J]. J Cell Biochem, 2009, 107(1):123.
[37]  Kuo W W, Huang C Y, Chung J G, et al. Crude extracts of Solanum lyratum protect endothelial cells against oxidized low-density lipoprotein-induced injury by direct antioxidant action[J]. Vasc Sury, 2009,50(4):849.
[38]  王昭晶. 麦冬提取物的抗氧化活性和抑菌作用研究[J]. 食品与发酵工业,2007,33(9):57.
[39]  赵自明,潘华山,冯毅翀.人参皂苷Rg1抗氧化能力的实验研究[J].江西中医学院学报,2009,21(1): 36.
[40]  戴红旗,鄢贵龙,刘沐东,等. 葛根提取物抗氧化活性研究[J]. 安徽农业科学, 2008,36(24):10508.

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