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生物技术在中药青蒿中的应用研究

Keywords: 青蒿,青蒿素,生物技术

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Abstract:

青蒿素是从中药青蒿中提取的治疗疟疾的最有效药物,但在青蒿中青蒿素的含量很低。作者从以下3个方面概述了生物技术在青蒿中的应用研究:一是通过DNA的分子标记辅助育种。应用于青蒿种质资源的遗传多样性研究,为高青蒿素含量优良品种的快速选育提供分子生物学基础;二是通过基因工程技术提高青蒿素的含量;在青蒿中过表达青蒿素生物合成的关键酶基因;抑制与青蒿素生物合成竞争相同底物的酶基因的表达,直接或间接的提高青蒿素的含量;三是通过合成生物学技术在宿主内生产青蒿素的前体或青蒿素。

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