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应答式释药系统构建方法的研究进展

Keywords: 应答释药,生物节律,外调式释药,自调式释药,脉冲释药,中药组分

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Abstract:

应答式释药系统能在特定时间、位点并根据生物节律变化释放药物,有效克服了机体耐药性,具有保护药物、局部靶向、抑制酶活性及记忆与表达等优点,具有良好的应用前景,目前已有多个化药制剂品种上市。该文主要综述了该释药系统构建方法的研究进展,同时考虑复杂中药(复方)中多组分、多环节、多靶点的整体作用特点,尝试提出了基于中药组分应答式释药系统的研究思路,以期"抛砖引玉",为该递药系统的发展提供借鉴与思考。

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