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口服微载体药物递送系统及其在中药研究中的应用

Keywords: 微粒,微载体给药系统,口服,中药

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Abstract:

载药微粒是一类应用前景广阔的定向、定位、控释给药系统载体。各种微载体给药系统在促进吸收,提高稳定性,定位、控制释放方面各有优势,如果能结合中药的特点,构建中药有效成分、有效部位、中药复方口服微载体给药系统,对中药新型给药系统的研究具有深远意义。该文主要介绍了几种可用于口服的微载体药物递送系统的特点和优势,并对其在中药领域中的应用进行了综述。

References

[1]  仲博. 辣椒碱肠溶微囊的制备及其特性考察. 石家庄:河北医科大学, 2011.
[2]  李药兰,许少玉,王卫华,等.茶多酚-聚乳酸缓释微囊的制备研究[J].中国中药杂志,2001,26(12): 829.
[3]  赵红, 魏巍, 张茂润,等. 丹皮酚缓释微球的制备及体内外相关性研究[J]. 安徽理工大学学报,2010, 30(2): 43.
[4]  陈东, 丁平田, 邓意辉, 等. 聚合物胶束用于口服给药的研究进展[J]. 药学学报, 2010, 45 (5): 560.
[5]  窦明金,黄桂.固体脂质纳米粒的研究进展[J].中国药事,2005,19(10): 597.
[6]  李厚丽,翟光喜.槲皮素固体脂质纳米粒的制备及小鼠口服吸收研究[J].中国药学杂志,2008,43(6): 435.
[7]  Wang D, Wang X, Li X, et al. Preparation and characterization of solid lipid nanoparticles loaded with alpha-Asarone[J]. PDA J Pharm Sci Technol, 2008, 62(1): 56.
[8]  胡海洋,刘任.口服芹菜素固体脂质纳米粒制剂学及药动学研究[J].中国药学杂志,2009,44(6): 448.
[9]  孙铭, 韩静. 紫杉醇固体脂质纳米粒大鼠体内药动学[J]. 沈阳药科大学学报, 2010, 27(3): 240.
[10]  Hu L, Xing Q, Meng J, et al. Preparation and enhanced oral bioavailability of cryptotanshinone-loaded solid lipid nanoparticles[J]. AAPS Pharm Sci Tech, 2010, 11(2): 582.
[11]  Hao J, Wang F, Wang X, et al. Development and optimization of baicalin-loaded solid lipid nanoparticles prepared by coacervation method using central composite design[J]. Eur J Pharm Sci, 2012, 47(2): 497.
[12]  Kocbek P, Baumgartner P, Kristl J. Preparation and evaluation of nanosuspensions for enhancing the dissolution of poorly soluble drugs[J]. Int J Pharm, 2006, 312(1/2): 179.
[13]  Muller R H, Katrin P. Nanosuspensions for the formulation of poorly soluble drugs I. Preparation by a size-reduction technique[J]. Int J Pharm, 1998, 160(1/2): 229.
[14]  蒲晓辉, 孙进, 秦一萌, 等. 抑制P-糖蛋白的羟基喜树碱纳米混悬剂的制剂学评价[J].药学学报, 2011, 46(7): 834.
[15]  蒲晓辉,孙进,张鹏,等.羟基喜树碱纳米混悬剂在Caco-2细胞模型中的吸收特性[J].沈阳药科大学学报,2013,30(2): 87.
[16]  Wang Y, Zhang D, Liu Z, et al. In vitro and in vivo evaluation of silybin nanosuspensions for oral and intravenous delivery[J]. Nanotechnology, 2010, 21(15): 155104.
[17]  She Zuo-Yan, Ke Xue, Ping Qi-Neng, et al. Preparation of breviscapine nanosuspension and its pharmacokinetic behavior in rats[J]. Chin J Nat Med, 2007, 15 (11): 50.
[18]  Gao Y, Wang C, Sun M, et al. In vivo evaluation of curcumin loaded nanosuspensions by oral administration[J]. J Biomed Nanotechnol, 2012, 8(4): 659.
[19]  陈进,代文婷,邢海燕,等.微载体药物递送系统在姜黄素中的应用研究进展[J].中国现代应用药学,2012,29(10): 885.
[20]  梅兴国. 微载体药物递送系统[M].武汉:华中科技大学出版社, 2009.
[21]  李凤前,陆彬.经胃肠道上皮吸收的微粒给药系统研究概况[J].国外医药,2000,21(5): 307.
[22]  张正全,陆彬.微乳给药系统研究概况[J].中国医药工业杂志,2001,32(3): 139.
[23]  Charman S A, Charman W N, Rogge M C, et al. Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound[J]. Pharm Res, 1992, 9(1): 87.
[24]  Gao P, Morozowich W. Development of supersaturatable self-emulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs[J]. Expert Opin Drug Deliv, 2006, 3(1): 97.
[25]  完茂林,刘子荣,桂双英,等.川芎嗪口服油包油微乳的研制及大鼠体内药物代谢动力学研究[J].安徽中医学院学报,2011,30(2): 60.
[26]  Du H, Yang X, Li H, et al. Preparation and evaluation of andrographolide-loaded microemulsion[J]. J Microencapsul, 2012, 29(7): 657.
[27]  Wu H, Lu C, Zhou A, et al. Enhanced oral bioavailability of puerarin using microemulsion vehicle[J]. Drug Dev Ind Pharm, 2009, 35(2): 138.
[28]  Gui S Y, Wu L, Peng D Y, et al. Preparation and evaluation of a microemulsion for oral delivery of berberine[J]. Pharmazie, 2008, 63(7): 516.
[29]  潘玉,李成森,郭晏华,等.苦参碱口服微乳的制备及含量测定[J].沈阳药科大学学报,2011,28(3): 177.
[30]  江来,刘欢,王春龙,等.水飞蓟宾口服微乳制备及性质评价[J].中草药,2008,31(1): 51.
[31]  袁中文,周郁斌,关世侠,等.灯盏花素口服微乳的制备[J].医药导报,2012,31(5): 655.
[32]  曾昭武,周广林,王小丽,等.-种榄香烯口服微乳相对生物利用度的初步研究[J].现代生物医学进展,2012,12(2): 218.
[33]  Qi J, Zhuang J, Wu W, et al. Enhanced effect and mechanism of water-in-oil microemulsion as an oral delivery system of hydroxysafflor yellow A[J]. Int J Nanomed, 2011, 6: 985.
[34]  柯学, 严菲, 胡一桥. 黄芩素自微乳的制备及大鼠体内生物利用度研究[J]. 中国新药杂志, 2010, 19(5): 371.
[35]  谢珺,温明,刘建明.齐墩果酸口服自微乳在大鼠体内的药动学研究[J].中成药,2012,34(2): 257.
[36]  Lu J L, Wang J C, Zhao S X, et al. Self-microemulsifying drug delivery system (SMEDDS) improves anticancer effect of oral 9-nitrocamptothecin on human cancer xenografts in nude mice[J]. Eur J Pharm Biopharm, 2008, 69(3): 899.
[37]  Wu X, Xu J, Huang X, et al. Self-microemulsifying drug delivery system improves curcumin dissolution and bioavailability[J]. Drug Dev Ind Pharm, 2011, 37(1): 15.
[38]  Mezghrani O, Ke X, Bourkaib N, et al. Optimized self-microemulsifying drug delivery systems(SMEDDS) for enhanced oral bioavailability of astilbin[J]. Pharmazie, 2011, 66(10): 754.
[39]  徐振中,杨坚,白娟,等.和厚朴酚口服自微乳制剂的制备及药代动力学研究[J].中国新药杂志,2012,21(8): 857.
[40]  游秀华, 王荣昌, 汤文星, 等. 自微乳化系统提高广藿香醇大鼠口服生物利用度[J]. 中国中药杂志, 2010, 35(6): 694.
[41]  熊颖, 胡志华, 朱金段, 等. 银杏酮酯口服自微乳的药物代谢动力学研究[J]. 中药新药与临床药理, 2011, 22(5): 542.
[42]  Gao P, Rush B D, Pfund W P, et al. Developmentofa supersatu-ratable SEDDS(S-SEDDS) formulation of paclitaxel with improved oral bioavailability[J]. J Pharm Sci, 2003, 92(12): 2386.
[43]  彭璇,陈苹苹,包强,等.水飞蓟宾过饱和自乳化给药系统的制备及性质研究[J].中草药,2010,41(1): 40.
[44]  姚金娜,陈苹苹,尚小广,等.水飞蓟宾过饱和自微乳给药系统在大鼠体内的药动学研究[J].中草药,2011,42(11): 2261.
[45]  Zhi-Qiang Chen, Ying Liu, Ji-Hui Zhao, et al. Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system[J]. Int J Nanomed, 2012, 7: 1115.
[46]  傅韶,方晓玲.三七总皂苷油包水微乳的处方筛选及体内外评价[J].药学学报,2007,42(7): 780.
[47]  张婧, 王木生. 香砂养胃口服微乳的处方优选及理化性质、稳定性考察[J]. 中国药房, 2011, 22(27): 2530.
[48]  杨丽娟,刘起华,黄果.交泰丸有效部位自微乳系统的体内外评价[J].中国中药杂志,2010,35(10): 1246.
[49]  卢文彪, 陈蔚文, 李茹柳. 连香方自微乳载药系统的研究[J]. 中药材, 2010, 33(3): 450.
[50]  李红磊,张忠义,成海民.丹参酮和丹酚酸复合微乳的初步研究[J].中药材,2006,29(4): 376.
[51]  Payne N I, Timmins P, Ambrose C V, et al. Proliposomes: a novel solution to an old problem[J]. J Pharm Sci, 1986, 75(4): 325.
[52]  袁琼英,刘厚钰,周康,等.甘草甜素脂质体和甘草甜素的药动学比较[J].中国新药杂志,2005,14(7): 903.
[53]  Song J, Shi F, Zhang Z, et al. Formulation and evaluation of celastrol-loaded liposomes[J]. Molecules, 2011, 16(9): 7880.
[54]  顾-珠,周文,翟光喜.葛根素脂质体的研制及其大鼠口服吸收[J].中药材,2007,30(8): 970.
[55]  王刚,常明泉,杨光义,等.槲皮素长循环纳米脂质体的小鼠口服吸收研究[J].医药导报,2011,30(10): 1266.
[56]  Sun Y, Zhao Y. Enhanced pharmacokinetics and anti-tumor efficacy of PEGylated liposomal rhaponticin and plasma protein binding ability of rhaponticin[J]. J Nanosci Nanotechnol, 2012, 12(10): 7677.
[57]  Chen H, Wu J, Sun M, et al. N-trimethyl chitosan chloride-coated liposomes for the oral delivery of curcumin[J]. J Liposome Res, 2012, 22(2): 100.
[58]  杨芰, 宋金春, 刘薇芝. 葛根素前体脂质体药动学和生物利用度[J]. 中国医院药学杂志, 2008, 28(2): 2075.
[59]  林薇,姚静,周建平.川陈皮素自组装前体脂质体的制备及其大鼠体内药代动力学研究[J].药学学报,2009,42(2): 192.
[60]  Yan-yu X, Yun-mei S, Zhi-peng C, et al. Preparation of silymarin proliposome: a new way to increase oral bioavailability of silymarin in beagle dogs[J]. Int J Pharm, 2006, 319(1/2): 162.
[61]  Chu C, Tong S S, Xu Y, et al. Proliposomes for oral delivery of dehydrosilymarin: preparation and evaluation in vitro and in vivo[J]. Acta Pharmacol Sin, 2011, 32(7): 973.
[62]  马廷升,李高,刘志华,等.盐酸青藤碱脂质体缓释片人体药动学与生物等效性研究[J].中国药学杂志,2009,44(3): 213.
[63]  赖玲,刘华钢,陆仕华,等.三七总皂苷肠溶微囊的药代动力学及体内外相关性研究[J].中国新药杂志,2012,21(6): 693.
[64]  Kwon S H, Kim S Y, Ha K W, et al. Pharmaceutical evaluation of genistein-loaded pluronic micelles for oral delivery[J]. Arch Pharm Res, 2007, 30(9): 1138.
[65]  吴益平, 霍美蓉, 周建平. 水飞蓟素-两亲性壳聚糖胶束的制备及其大鼠在体肠吸收[J].药学学报, 2009, 44: 651.
[66]  Kim S, Kim J Y, Huh K M, et al. Hydrotropic polymer micelles containing acrylic acid moieties for oral delivery of paclitaxel[J]. J Controlled Release, 2008, 132(3): 222.
[67]  Dahmani F Z, Yang H, Zhou J, et al. Enhanced oral bioavailability of paclitaxel in pluronic/LHR mixed polymeric micelles: preparation, in vitro and in vivo evaluation[J]. Eur J Pharm Sci, 2012, 47(1): 179.

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