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药用植物萜类生物合成HMGR基因研究进展

Keywords: HMGR,萜类化合物,药用植物

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Abstract:

药用植物中萜类次生代谢产物种类丰富,数量巨大,其现代药理活性相当突出.3-羟基-3-甲基戊二酰辅酶A还原酶(3-hydroxy-3-metllylglutarylcoenzymeAreductase,HMGR)作为萜类成分甲羟戊酸(MVA)合成途径上第一个重要限速酶,对药用植物萜类活性成分生物合成过程起着至关重要的作用.文章系统综述了HMGR的生物学意义、催化机制,HMGR克隆情况、基因结构、以及在重要药用植物丹参、甘草、红豆杉等中的研究进展.

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