全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

三七皂苷对神经系统疾病药理作用机制研究进展

Keywords: 三七皂苷,神经系统疾病,雌激素样活性,药理机制,研究进展

Full-Text   Cite this paper   Add to My Lib

Abstract:

通过综述三七皂苷,包括三七总皂苷、三七三醇皂苷、三七二醇皂苷、人参皂苷Rg1、人参皂苷Rb1、人参皂苷Re和三七皂苷R1对神经系统疾病(阿尔茨海默病、帕金森病、缺血性脑中风和抑郁症)的药理作用,对比分析三七皂苷对神经系统疾病的药理作用研究热点及潜在优势(如类雌激素作用),为进一步的药理研究提供参考,也为临床上对神经系统疾病的治疗、药物的研究开发提供新的思路。

References

[1]  冷静,傅超美,万方.三七三醇皂苷化学成分及药理作用的研究进展[J].华西药学杂志,2011,26(1):83.
[2]  黄金兰,陆璐,黄丹,等.三七总皂苷对快速老化模型小鼠大脑β-分泌酶活性及含量的影响[J].中国中西医结合杂志,2013,33(7):944.
[3]  Shi C, Na N, Zhu X, et al. Estrogenic effect of ginsenoside Rg1 on APP processing in post-menopausal platelets[J]. Platelets,2013,24(1):51.
[4]  Wu J, Pan Z, Wang Z, et al. Ginsenoside Rg1 protection against beta-amyloid peptide-induced neuronal apoptosis via estrogen receptor alpha and glucocorticoid receptor-dependent anti-protein nitration pathway[J]. Neuropharmacology,2012,63(3):349.
[5]  林智颖. 人参皂苷Rb1通过抑制L-型电压门控钙通道的活性改善Aβ(25-35)诱导的海马神经元钙平衡紊乱[D]. 福州:福建医科大学,2009.
[6]  钟振国,屈泽强,王乃平,等. 三七总皂苷对阿尔茨海默病大鼠脑胆碱能神经的保护作用[J]. 中国临床康复,2006,10(19):174.
[7]  宋晓斌,何波,陈鹏,等. 三七皂苷Rg1对动物学习记忆功能的影响及其机理研究[J]. 昆明医学院学报,2010,31(6):21.
[8]  Wang Q, Sun L H, Jia W, et al. Comparison of ginsenosides Rg1 and Rb1 for their effects on improving scopolamine-induced learning and memory impairment in mice[J]. Phytother Res, 2010, 24(12):1748.
[9]  吕良,钟振国,吴登攀,等. 三七总皂苷对快速老化模型小鼠脑内syp,tau基因表达的影响[J]. 中国中药杂志,2009,34(10):1261.
[10]  Zhao H H, Di J, Liu W S, et al. Involvement of GSK3 and PP2A in ginsenoside Rb1\'s attenuation of aluminum-induced tau hyperphosphorylation[J]. Behav Brain Res, 2013, 241:228.
[11]  徐岚,洪震.阿尔茨海默病的药物治疗进展[J].医药导报,2009,28(9):1182.
[12]  尚远宏,徐晓玉.中药及其提取物对脑缺血保护作用的实验研究进展[J].中国中药杂志,2013,38(8):1109.
[13]  蒋媛静. 血栓通粉针(三七总皂苷)对大鼠脑缺血再灌注损伤后Bcl-2蛋白表达的影响[J]. 中国中医急症,2013,22(9):1546.
[14]  Jiang B, Xiong Z, Yang J, et al. Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus[J]. Br J Pharmacol, 2012, 166(6):1872.
[15]  杨志刚,陈阿琴,俞颂东,等.三七皂苷药理作用研究进展[J].中国兽药杂志,2005,39(1):33.
[16]  吴思缈,周黎明.阿尔茨海默病的发病机制及药物治疗的进展[J].四川生理科学杂志,2009,31(1):36.
[17]  庄莹,陈杰.阿尔茨海默病病因及发病机制研究进展[J].吉林医药学院学报,2008,29(2):101.
[18]  钟振国,吕良,柴立民,等.三七总皂苷对快速老化模型小鼠SAMP8脑内APP基因转录的影响[J].中药材,2011,34(1):77.
[19]  黄金兰,李霏,吴登攀,等.三七总皂苷对快速老化SAMP8小鼠大脑α-分泌酶mRNA表达的影响[J].中国中药杂志,2012,37(14):2127.
[20]  Zhang X, Wang J, Xing Y, et al. Effects of ginsenoside Rg1 or 17beta-estradiol on a cognitively impaired, ovariectomized rat model of Alzheimer\'s disease[J]. Neuroscience,2012,220:191.
[21]  Fang F, Chen X, Huang T, et al. Multi-faced neuroprotective effects of ginsenoside Rg1 in an Alzheimer mouse model[J]. Biochim Biophys Acta,2012,1822(2):286.
[22]  Quan Q, Wang J, Li X, et al. Ginsenoside Rg1 decreases Abeta1-42 level by upregulating PPAR gamma and IDE expression in the hippocampus of a rat model of Alzheimer\'s disease[J]. PLoS ONE,2013,8(3):e59155.
[23]  吴佳莹,沈圆圆,朱闻杰,等.人参皂苷Rg1经线粒体通路抗Aβ25-35致原代大鼠皮层神经元凋亡[J]. 浙江大学学报:医学版,2012,41(4):393.
[24]  Yan J, Liu Q, Dou Y, et al. Activating glucocorticoid receptor-ERK signaling pathway contributes to ginsenoside Rg1 protection against beta-amyloid peptide-induced human endothelial cells apoptosis[J]. J Ethnopharmacol,2013,147(2):456.
[25]  Xie X, Wang H T, Li C L, et al. Ginsenoside Rb1 protects PC12 cells against beta-amyloid-induced cell injury[J]. Mol Med Rep,2010,3(4):635.
[26]  Zhao R, Zhang Z, Song Y, et al. Implication of phosphatidylinositol-3 kinase/Akt/glycogen synthase kinase-3beta pathway in ginsenoside Rb1\'s attenuation of beta-amyloid-induced neurotoxicity and tau phosphorylation[J]. J Ethnopharmacol,2011,133(3):1109.
[27]  盛树力.老年性痴呆:从分子生物学到临床诊治[M].北京:科学技术文献出版社,1998:109.
[28]  Yin L M, Wang X, Qian X D, et al. Effects of Panax notoginseng saponins on proliferation and differentiation in NIH3T3 cells[J]. Chin J Integr Med, 2012, 18(8):616.
[29]  韦永胜,黄雨兰.三七通舒胶囊治疗缺血性脑卒中的临床疗效观察[J].成都中医药大学学报,2009,32(2):35.
[30]  朱观祥,陈卫银,黄梅,等.三七二醇皂苷预处理诱导脑缺血耐受及对热休克蛋白-70表达的影响[J].中国中医急症,2009,18(9):1468.
[31]  王巧云,刘凤,吴峰阶,等.人参皂苷Rg1对局灶性脑缺血再灌注损伤大鼠海马p-ERK1/2与p-JNK表达的影响[J]. 中国中西医结合杂志,2013,32(2):229.
[32]  Jiang Z, Wang Y, Zhang X, et al. Preventive and therapeutic effects of ginsenoside Rb1 for neural injury during cerebral infarction in rats[J]. Am J Chin Med, 2013, 41(2):341.
[33]  Zhu J, Jiang Y, Wu L, et al. Suppression of local inflammation contributes to the neuroprotective effect of ginsenoside Rb1 in rats with cerebral ischemia[J]. Neuroscience, 2012, 202:342.
[34]  Liang J, Yu Y, Wang B, et al. Ginsenoside Rb1 attenuates oxygen-glucose deprivation-induced apoptosis in SH-SY5Y cells via protection of mitochondria and inhibition of AIF and cytochrome c release[J]. Molecules, 2013, 18(10):12777.
[35]  X Meng, M Wang, X Wang, et al. Suppression of NADPH oxidase-and mitochondrion-derived superoxide by notoginsenoside R1 protects against cerebral ischemia-reperfusion injury through estrogen receptor-dependent activation of Akt/Nrf2 pathways[J]. Free Radical Res,2014,doi:10.3109/10715762.2014.911853.
[36]  宋志斌,朱成琳,师方园,等.人参皂苷Re体外抗氧化能力及其对血清剥夺神经细胞作用的研究[J]. 中国实验方剂学杂志,2012,18(7):225.
[37]  Xu L, Chen W F, Wong M S. Ginsenoside Rg1 protects dopaminergic neurons in a rat model of Parkinson\'s disease through the IGF-I receptor signalling pathway[J]. Br J Pharmacol, 2009, 158(3):738.
[38]  徐琲琲,刘纯青,马涛,等.人参皂苷Re对MPTP致帕金森病模型小鼠多巴胺能神经元的保护作用[J]. 沈阳药科大学学报,2005,22(1):36.
[39]  Luo F C, Wang S D, Qi L, et al. Protective effect of panaxatriol saponins extracted from Panax notoginseng against MPTP-induced neurotoxicity in vivo[J]. J Ethnopharmacol, 2011, 133(2):448.
[40]  Hashimoto R, Yu J, Koizumi H, et al. Ginsenoside Rb1 prevents MPP(+)-induced apoptosis in PC12 cells by stimulating estrogen receptors with consequent activation of ERK1/2, Akt and inhibition of SAPK/JNK, p38 MAPK[J]. Evid Based Complement Alternat Med, 2012,doi:693717.
[41]  付珊,杨贞. 三七皂苷对急性和慢性应激抑郁模型大鼠抗抑郁样作用的研究[J]. 中国医药指南,2012,10(19):113.
[42]  Xiang H, Liu Y, Zhang B, et al. The antidepressant effects and mechanism of action of total saponins from the caudexes and leaves of Panax notoginseng in animal models of depression[J]. Phytomedicine, 2011, 18(8/9):731.
[43]  Lee S H, Hur J, Lee E H, et al. Ginsenoside Rb1 modulates level of monoamine neurotransmitters in mice frontal cortex and cerebellum in response to immobilization stress[J]. Biomol Ther (Seoul), 2012, 20(5):482.
[44]  Cui J, Jiang L, Xiang H. Ginsenoside Rb3 exerts antidepressant-like effects in several animal models[J]. J Psychopharmacol, 2012, 26(5):697.
[45]  黄倩,楚世峰,张均田,等. 人参皂苷Rg1的抗抑郁作用及对突触超微结构的影响[J]. 中国药理学通报,2013,29(8):1124.
[46]  潘静,陈生弟. NMDA受体与神经退行性疾病的关系[J]. 上海交通大学学报:医学版,2009,29(1):98.
[47]  Gu B, Nakamichi N, Zhang W S, et al. Possible protection by notoginsenoside R1 against glutamate neurotoxicity mediated by N-methyl-D-aspartate receptors composed of an NR1/NR2B subunit assembly[J]. J Neurosci Res, 2009, 87(9):2145.
[48]  Liang W, Ge S, Yang L, et al. Ginsenosides Rb1 and Rg1 promote proliferation and expression of neurotrophic factors in primary Schwann cell cultures[J]. Brain Res, 2010, 1357:19.
[49]  蔡志友,晏勇.小胶质细胞与阿尔茨海默病[J].生命科学,2008,20(1):95.
[50]  黄丹宇,叶民.小胶质细胞与帕金森病[J].中国组织工程研究,2012,16(24):4549.
[51]  黄金兰,陆璐,黄丹,等.三七总皂苷对快速老化痴呆模型小鼠SAMP8炎症因子及小胶质细胞的影响[J].中国实验方剂学杂志,2013,19(8):171.
[52]  Zong Y, Ai Q L, Zhong L M, et al. Ginsenoside Rg1 attenuates lipopolysaccharide-induced inflammatory responses via the phospholipase C-gamma1 signaling pathway in murine BV-2 microglial cells[J]. Curr Med Chem, 2012, 19(5):770.
[53]  Lee J S, Song J H, Sohn N W, et al. Inhibitory effects of ginsenoside Rb1 on neuroinflammation following systemic lipopolysaccharide treatment in mice[J]. Phytother Res, 2013, 27(9):1270.
[54]  曹德晨,只达石,张赛.雌激素和孕激素的神经保护作用[J].中国脑血管病杂志,2005,2(2):90.
[55]  谈智,王庭槐.雌激素作用分子机制研究进展[J].中国病理生理杂志,2003,19(10):127.
[56]  Wu P F, Zhang Z, Wang F, et al. Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury[J]. Acta Pharmacol Sin, 2010, 31(12):1523.
[57]  董晓强,董文天,洪霞,等. 三七、人参和西洋参化学成分与药效学之间的关系[J]. 承德医学院学报,2011,28(3):307.
[58]  Saw C L, Yang A Y, Cheng D C, et al. Pharmacodynamics of ginsenosides: antioxidant activities, activation of Nrf2, and potential synergistic effects of combinations[J]. Chem Res Toxicol, 2012, 25(8):1574.
[59]  Chula S, Hang L, Yinying B, et al. The effects of notoginsenoside R1 on the intestinal absorption of geniposide by the everted rat gut sac model[J]. J Ethnopharmacol, 2012, 142(1):136.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133