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基于网络分析的补阳还五汤防治气虚血瘀型疾病机制研究

Keywords: 网络分析,补阳还五汤,气虚血瘀,靶点-靶点网络,化学成分-靶点-疾病网络

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Abstract:

该研究采用网络分析方法从化学成分、靶点、疾病3个层面对补阳还五汤进行研究,发现补阳还五汤在肿瘤治疗方面的潜力;并对补阳还五汤基于疾病的"靶点-靶点"网络进行分析,通过计算结点中心度、接近中心度、中介中心度、特征向量中心度4个网络指标,对网络中靶点的重要性与显著性进行综合评价,挖掘补阳还五汤作用的关键靶点,得到COX-2与PPAR-γ2个重要靶点,提示这2个靶点可能是参与气虚血瘀型疾病病理过程的重要靶点.同时,以这2个靶点为基础,构建补阳还五汤"化学成分-靶点-疾病"的核心网络,为深入研究补阳还五汤治疗气虚血瘀型疾病的机制提供参考.研究表明,网络分析方法有助于挖掘补阳还五汤治疗气虚血瘀型疾病的潜在作用靶点,可为从系统层面揭示补阳还五汤作用机制提供方法学参考,对中药方剂的作用机制阐释和新药研发具有指导意义.

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