Taki N, Kira N, Ishii T, et al. Bufalin, a traditional oriental medicine, induces apoptosis in human cancer cells [J]. Asian Pac J Cancer Prev, 2012,13:399.
[4]
Cao Y, Li H X, Xu L T, et al. Bufalin enhances the anti-proliferative effect of sorafenib on human hepatocellular carcinoma cells through downregulation of ERK [J]. Mol Biol Rep, 2012,39(2):1683.
Qi F, Inagaki Y, Gao B, et al. Bufalin and cinobufagin induce apoptosis of human hepatocellular carcinoma cells via Fas- and mitochondria-mediated pathways[J]. Cancer Sci, 2011,102(5):951.
[8]
Miao Q, Bi L L, Li X, et al. Anticancer effects of bufalin on human hepatocellular carcinoma HepG2 cells: roles of apoptosis and autophagy[J]. Int J Mol Sci, 2013,14(1):1370.
[9]
Hsu C M, Tsai Y, Wan L, et al. Bufalin induces G2/M phase arrest and triggers autophagy via the TNF, JNK, BECN-1 and ATG8 pathway in human hepatoma cells[J]. Int J Oncol, 2013,43(1):338.
Jiang Y,Zhang Y,Luan J,et al. Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action [J].Cytotechnology,2010, 62(6):573.
[12]
Zhu Z, Sun H, Ma G, et al. Bufalin induces lung cancer cell apoptosis via the inhibition of PI3K/Akt pathway[J]. Int J Mol Sci, 2012,13(2):2025.
[13]
Kang X H, Xu Z Y, Gong Y B, et al. Bufalin reverses HGF-induced resistance to EGFR-TKIs in EGFR mutant lung cancer cells via blockage of Met/PI3k/Akt pathway and induction of apoptosis[J]. Evid Based Complement Alternat Med, 2013,doi:243859.
Zhu Z, Li E, Gao Y, et al. Inhibition of Jak-STAT3 pathway enhances bufalin-induced apoptosis in colon cancer SW620 cells[J]. World J Surg Oncol, 2012, 10:228.
[17]
Xie C M, Chan W Y, Yu S, et al. Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation [J]. Free Radic Biol Med, 2011,51(7):1365.
Huang C J, Chen A L, Guo M, et al. Membrane dielectr icresponses o f bufa lin-induced apoptosis in HL-60 cells detected by an electrorotation chip[J]. Biotechnol Lett, 2007,29(9):1307.
[23]
Watabe M, Kawazoe N, Masuda Y, et al. Bcl-2 Protein inhibits bufalin-induced apoptosis through inhibition of mitogen-activated protein kinase activation in human leukemia U937 cells[J]. Cancer Res, 1997,57(15):3097.
[24]
Chen A, Yu J, Zhang L, et al. Microarray and biochemical analysis of bufalin-induced apoptosis of HL-60 cells[J]. Biotechnol Lett, 2009,31(4):487.
[25]
Zhu Z, Li E, Liu Y, et al. Bufalin induces the apoptosis of acute promyelocytic leukemia cells via the downregulation of survivin expression [J]. Acta Haematol, 2012,128(3):144.
Hong S H, Choi Y H. Bufalin induces apoptosis through activation of both the intrinsic and extrinsic pathways in human bladder cancer cells[J]. Oncol Rep, 2012, 27(1):114.
[28]
Huang W W, Yang J S, Pai S J, et al. Bufalin induces G(0)/G(1) phase arrest through inhibiting the levels of cyclin D, cyclin E, CDK2 and CDK4, and triggers apoptosis via mitochondrial signaling pathway in T24 human bladder cancer cells[J]. Mutat Res, 2012,732(1/2):26.
[29]
Hong S H, Kim G Y, Chang Y C, et al. Bufalin prevents the migration and invasion of T24 bladder carcinoma cells through the inactivation of matrix metalloproteinases and modulation of tight junctions[J]. Int J Oncol, 2013,42(1):277.
Xie X B, Yin J Q, Wen L L, et al. Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based research [J]. PLoS ONE,2012,7(10): e47375.
[32]
Chueh F S, Chen Y Y, Huang A C, et al. Bufalin-inhibited migration and invasion in human osteosarcoma U-2 OS cells is carried out by suppression of the matrix metalloproteinase-2, ERK, and JNK signaling pathways [J]. Environ Toxicol, 2011,doi: 10.1002/tox.20769.
Chen Y, Guo Q, Zhang B, et al. Bufalin enhances the antitumor effect of gemcitabine in pancreatic cancer[J]. Oncol Lett, 2012,4(4):792.
[35]
Nasu K, Nishida M, Ueda T, et al. Bufalin induces apoptosis and the G0/G1 cell cycle arrest of endometriotic stromal cells: a promising agent for the treatment of endometriosis[J]. Mol Hum Repros, 2005,11(11):817.
[36]
Takai N, Ueda T, Nishida M, et al.Bufalin induces growth inhibition,cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells[J]. Int J Mol Med, 2008, 21(5): 637.
[37]
Yan S, Qu X, Xu C, et al. Down-regulation of Cbl-b by bufalin results in up-regulation of DR4/DR5 and sensitization of TRAIL-induced apoptosis in breast cancer cells[J]. J Cancer Res Clin Oncol, 2012,138(8):1279.
Liu Y, Wang P, Sun C, et al. Wheat germ agglutinin-grafted lipid nanoparticles: preparation and in vitro evaluation of the association with Caco-2 monolayers[J]. Int J Pharm, 2010, 397(1/2):155.
[42]
Liu Y, Wang P, Sun C, et al. Bioadhesion and enhanced bioavailability by wheat germ agglutinin-grafted lipid nanoparticles for oral delivery of poorly water-soluble drug bufalin[J]. Int J Pharm, 2011,419(1/2):260.
Yin P, Wang Y, Qiu Y, et al. Bufalin-loaded mPEG-PLGA-PLL-cRGD nanoparticles: preparation, cellular uptake, tissue distribution, and anticancer activity [J]. Int J Nanomed, 2012,7:3961.
Yeh J Y, Huang W J, Kan S F, et al.Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells[J].Prostate, 2003, 54(2):112.
[47]
Yu C H, Kan S F, Pu H F, et al. Apoptotic signaling in bufalinand cinobufagin treated androgen-dependent and independent human prostate cancer cells[J]. Cancer Scir, 2008, 99(12): 2467.
