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草豆蔻中一个新的二氢黄酮及其对PC12细胞的神经保护作用

Keywords: 草豆蔻,二氢黄酮,PC12细胞,活性氧

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Abstract:

该文对草豆蔻Alpiniakatsumadai中的黄酮类化学成分进行了研究。通过硅胶,SephadexLH-20等柱色谱和制备液相等多种色谱方法,从草豆蔻95%乙醇提取物中分离得到7个黄酮类化合物。根据理化性质和波谱数据分别鉴定为(2R,3S)-pinobanksin-3-cinnamate(1)、乔松素(2)、短叶松素(3)、3-O-乙酰基短叶松素(4)、高良姜素(5)、华良姜素(6)、山柰酚-3-甲醚(7)。其中化合物1为新化合物,其他6个为已知化合物。药理活性研究表明,化合物1对皮质酮损伤的PC12细胞有很强的保护作用,其机制可能是通过清除细胞内活性氧发挥效果。

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