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吊球草的化学成分及抑菌活性研究

Keywords: 吊球草,化学成分,抑菌活性

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Abstract:

研究吊球草Hyptisrhomboidea的化学成分,并对部分单体化合物进行抑菌活性测定。采用ToyopearlHW-40,SephadexLH-20,MCI-GelCHP-20,RP-18,PTLC及硅胶等色谱法对吊球草进行化学成分研究,根据理化性质和波谱技术鉴定化合物的结构,并评价部分单体化合物对8种植物病原菌的抑菌活性。从乙酸乙酯部位中共分离鉴定了11个化合物,分别为咖啡酸乙酯(1)、熊果酸(2)、齐墩果酸(3)、vanillacticacid(4)、迷迭香酸甲酯(5)、山柰酚-3-O-α-L-吡喃鼠李糖-(1→6)-β-D-吡喃葡萄糖苷(6)、山柰酚-3-O-α-L-吡喃鼠李糖-(1→2)-β-D-吡喃葡萄糖苷(7)、冬青素A(8)、β-香树脂醇(9)、山柰酚-3-O-β-D-吡喃葡萄糖苷(紫云英苷,10)和胆甾-5-烯-3β,4β-二醇(11)。其中化合物1对核盘菌的抑制活性最强,MIC为16.2mg·L-1,化合物5对玉米大斑病菌和小核盘菌的抑制活性最强,MIC分别为8.1,16.2mg·L-1。所有化合物均为首次从该植物中分离得到,化合物1,5具有较强的抗真菌活性。

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