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美洲刺人参酚类化学成分研究

Keywords: 美洲刺人参,苯丙素,香豆素,木脂素

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Abstract:

利用正向硅胶、反相硅胶、SephadexLH-20和制备液相色谱等多种分离技术进行分离纯化,依据理化性质和波谱数据鉴定结构,从美洲刺人参Oplopanaxhorridus的根皮醇提物乙酸乙酯和正丁醇萃取部位分离并鉴定了16个酚类化合物,其中7个苯丙素类成分阿魏酸(1),3-乙酰咖啡酸(2),咖啡酸(3),3-甲氧基二氢肉桂醇-4-O-β-D-葡萄糖苷(4),3-羟基二氢肉桂醇-4-O-β-D-葡萄糖苷(5),3,5-二甲氧基肉桂醇-4-O-β-D-葡萄糖苷(6),3-甲氧基肉桂醇-4-O-β-D-葡萄糖苷(7);3个香豆素类成分,东莨菪内酯(8),6,7-二羟基香豆素(9),反式-3’-当归酰基-4’-乙酰基角型吡喃香豆素(10);6个木脂素类成分,(+)-异落叶松脂素9’-O-β-D-葡萄糖苷(11),3,3’-二甲氧基-4,9,9’-三羟基-4’,7-环氧-5’,8-木脂素-4,9-O-β-D-二葡萄糖苷(12),(+)-5,5’-二甲氧基落叶松脂素4’-O-β-D-葡萄糖苷(13),(-)-5,5’-二甲氧基落叶松脂素4’-O-β-D-葡萄糖苷(14),(-)-松脂醇4’-O-β-D-葡萄糖苷(15),(±)-5,5’-二甲氧基落叶松脂素9’-O-β-D-葡萄糖苷(16)。所有化合物均为首次从该植物中分离得到,除化合物4,6,12和13外,其余化合物均为首次从该属植物中报道。

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