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TRPV1与中药止痛作用研究进展

Keywords: TRPV1,中药,止痛

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Abstract:

瞬时感受器电位香草酸受体l(trannsientreceptorpotentialvanilloid1,TRPV1)是一种非选择性阳离子通道,主要表达在感觉神经元上,属于瞬时感受器电位(transientreceptorpotential,TRP)家族成员之一。该受体可被机械性刺激,化学性刺激或内源性配基等激活,介导疼痛的传递,导致机体功能损伤。中医认为疼痛的发生机制为“不通则痛”,寒性收引和瘀血阻滞均能导致血脉不通而疼痛,清热解毒中药多数具有抗炎效果,温里药和活血化瘀药具有通畅血脉的作用。因此,无论从抗炎角度或通脉角度,清热解毒药、温里药和活血化瘀药均具有止痛作用。该文以TRPV1为靶点,对上述3类中药的止痛作用研究进行了综述。

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