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神经干细胞增殖信号通路网络分析

Keywords: 神经干细胞,增殖,Notch,Wnt,Shh,中药,网络药理学

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Abstract:

脑内神经干细胞具有增殖和分化能力,对脑皮质功能重建非常关键,寻找调控脑内神经干细胞增殖的关键靶点和网络通路意义重大,也是医学界亟待解决的难题。该文以Notch通路作为网络核心,总结了国内外对Wnt,Shh,EGFR,细胞因子等信号与Notch信号通路构成的生物分子网络系统进展,重点分析了Notch通路中的Notch受体,CBF1,NICD,Hes1等关键节点,这些节点可能成为未来新型药物作用的潜在靶点。中药具有多成分、多靶点、多层次的特点,与网络药理学有共通之处。中药的有效成分组或活性成分群是其发挥网络药理学效应的物质基础之一,值得深入探索。该文旨在为中药治疗神经退行性病变和神经损伤提供新的策略。

References

[1]  杜冠华,王月华,张冉,等.多成分多靶点是对中药作用机制的表面认识[J].世界科学技术--中医药现代化,2009,11(4):480.
[2]  杜冠华.中药复方有效成分组学研究[J].中成药, 2002, 24(11):878.
[3]  Keejung Yoon, Nicholas Gaiano. Notch signaling in the mammalian central nervous system: insights from mouse mutants[J]. Nat Neurosci, 2005, 8(6):709.
[4]  Alexson T O, Hitoshi S, Coles B L, et al. Notch signaling is required to maintain all neural stem cell populations -irrespective of spatial or temporal niche[J]. Dev Neurosci, 2006, 28(1/2):34.
[5]  Mizutani K, Yoon K, Dang L, et al. Differential Notch signalling distinguishes neural stem cells from intermediate progenitors[J]. Nature, 2007, 449(7160): 351.
[6]  Haupt S, Borghese L, Brüstle O, et al. Non-genetic modulation of Notch activity by artificial delivery of Notch intracellular domain into neural stem cells[J]. Stem Cell Rev, 2012, 8(3):672.
[7]  Shimizu T, Kagawa T, Inoue T, et al. Stabilized β-catenin functions through TCF/LEF proteins and the Notch/RBP-Jκ complex to promote proliferation and suppress differentiation of neural precursor cells[J]. Mol Cell Biol, 2008, 28(24):7427.
[8]  Stegman M A, Vallance J E, Elangovan G, et al. Identification of a tetrameric hedgehog signaling complex[J]. J Biol Chem, 2000, 275(29):21809.
[9]  Cai C, Thorne J, Grabel L, et al. Hedgehog serves as a mitogen and survival factor during embryonic stem cell neurogenesis[J]. Stem Cells, 2008, 26(5): 1097.
[10]  Dave R K, Ellis T, Toumpas M C, et al. Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors[J]. PLoS One, 2011, 6(3):e14680.
[11]  Ingram W J, McCue K I, Tran T H, et al. Sonic hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signaling[J]. Oncoqene, 2008, 27(10):1489.
[12]  Ayuso-Sacido A, Moliterno J A, Kratovac S, et al. Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells[J]. J Neurooncol, 2010, 97(3): 323.
[13]  Nagao M, Sugimori M, Nakafuku M. Cross talk between notch and growth factor/cytokine signaling pathways in neural stem cells[J]. Mol Cell Biol, 2007, 27(11):3982.
[14]  Andreu-Agulló C, Morante-Redolat J M, Delgado A C, et al. Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone[J]. Nat Neurosci, 2009, 12(12):1514.
[15]  Sivakumar K C, Dhanesh S B, Shobana S, et al. A systems biology approach to model neural stem cell regulation by Notch, Shh, Wnt, and EGF signaling pathways[J]. OMICS, 2011, 15(10):729.
[16]  刘艾林,杜冠华.网络药理学:药物发现的新思想[J]. 药学学报, 2010, 45(12):1472.
[17]  刘庆山,张梓倩,方亮,等.高通量技术与网络药理学在中药活性成分筛选中的应用[J].中国中药杂志,2012,37(2):134.
[18]  Vilas-Boas F, Fior R, Swedlow J R, et al. A novel reporter of notch signalling indicates regulated and random notch activation during vertebrate neurogenesis[J]. BMC Biol, 2011, 9:58.
[19]  Logan C Y, Nusse R. The Wnt signaling pathway in development and disease[J]. Annu Rev Cell Dev Biol, 2004, 20:781.
[20]  柴丽娟,钟佩茹,周志焕,等.黄芪甲苷对体外神经干细胞增殖作用影响的研究[J].中国药理学通报,2010,26(5):670.
[21]  Kwon C, Cheng P, King I N, et al. Notch post-translationally regulates β-catenin protein in stem and progenitor cells[J]. Nat Cell Biol, 2011, 13(10):1244.
[22]  Sanders P G, Munoz-Descalzo S, Balayo T, et al. Ligand-independent traffic of notch buffers activated armadillo in drosophil[J]. PLoS Biol, 2009, 7(8): e1000169.
[23]  Collu G M, Hidalgo-Sastre A, Acar A, et al. Dishevelled limits Notch signalling through inhibition of CSL[J]. Development, 2012, 139(23):4405.
[24]  Ayuso-Sacido A, Graham C, Greenfield J P, et al. The duality of epidermal growth factor receptor (EGFR) signaling and neural stem cell phenotype: cell enhancer or cell transformer?[J]. Curr Stem Cell Res Ther, 2006, 1(3):387.
[25]  袁红霞,赵强,黄文政,等.善胃方对气阴两虚型胃癌前期病变EGF及EGFR的影响[J].天津中医药,2004,21(1):9.
[26]  Aguirre A, Rubio M E, Gallo V. Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal[J]. Nature, 2010, 467(7313):323.
[27]  Campos L S, Decker L, Taylor V, et al. Notch, epidermal growth factor receptor, and β1-integrin pathways are coordinated in neural stem cells[J]. J Biol Chem, 2006, 281(8):5300.
[28]  Egger B, Gold K S, Brand A H. Regulating the balance between symmetric and asymmetric stem cell division in the developing brain[J]. Fly(Austin), 2011, 5(3):237.
[29]  马潞,刘文科,张跃康,等.川芎嗪对重型脑损伤组织BDNF、bFGF表达的影响及对神经元的保护作用[J].四川大学学报:医学版,2008,39(2):207.
[30]  庄朋伟,张艳军,庞坦.人参皂苷Rg1促进体外培养神经干细胞增殖的研究[J].中国中药杂志,2009,34(4):443.

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