全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用：99美元
投递稿件

查看量下载量

相关文章

更多...

延胡索物质基础研究

Keywords: 延胡索,生物碱,药效物质基础

Full-Text   Cite this paper   Add to My Lib

Abstract:

延胡索是常用传统中药之一，主要化学成分为原小檗碱类和阿朴啡类生物碱。该文概述延胡索所含生物碱成分的研究，分析其结构类型及新的定性、定量方法；分析其生物转化、吸收、分布、代谢、排泄、药代动力学、药物相互作用等特点，为确定延胡索的药效物质基础提供科学依据。

 References

[1]  傅小勇,梁文藻,涂国士.东阳元胡块茎中的生物碱的化学研究[J].药学学报,1986,21(6):447.
[2]  傅小勇, 梁文藻, 涂国士. 元胡块茎中生物碱的化学研究[J]. 中草药, 1986, 17(12):533.
[3]  王文蜀,肖巍,喻蓉,等.中药延胡索化学成分研究[J].中央民族大学学报:自然科学版,2007,16(1):80.
[4]  程星烨, 郑顺亮, 孙虹, 等. 延胡索抗心肌缺血有效部位化学成分研究[J]. 中药材, 2008, 31(11):1656.
[5]  Zhou Q, Deng A J, Qin H L. Two new quaternary protoberberine alkaloids from Corydalis yanhusuo[J]. J Asian Nat Prod Res, 2012, 14(5):476.
[6]  杨鑫宝,刘扬子,杨秀伟,等.磐安延胡索的化学成分研究[J].中草药,2013,44(16):2200.
[7]  Hemmi F. The carbohydrates of the edible tubers of Japan[J]. J Coll Agric Hokkaido Imp Univ, 1918, 8:33.
[8]  刘振华,王如伟,何厚洪,等.三甲基硅烷衍生化GC-MS研究延胡索中水溶性非生物碱类化学成分[J].中国中药杂志,2012,37(14):2108.
[9]  王鹏飞,王倩倩,李先恩,等. GC-MS技术在延胡索块茎代谢产物研究中的应用[J].植物学报,2012,47(2):149.
[10]  Tao Y W, Tian G Y. Studies on the physicochemical properties, structure and antitumor activity of polysaccharide YhPS-1 from the root of Corydalis yanhusuo Wang[J]. Chin J Chem, 2006, 24(2):235.
[11]  苏莉. ICP-MS法测定延胡索中5种金属元素的含量[J].广州化工,2012,40(1):94.
[12]  徐皓.火焰原子吸收光谱法测定元胡块茎中的微量元素[J].光谱实验室,2012,29(1):306.
[13]  王兆华,张大军,杜桂芝,等.延胡索及水煎液中14种无机元素的测定[J].广东微量元素科学,1998,5(11):34.
[14]  Wang C R, Guo Z M, Zhang J, et al. High-performance purification of quaternary alkaloids from Corydalis yanhusuo W.-T. Wang using a new polar-copolymerized stationary phase[J]. J Sep Sci, 2011, 34(1):53.
[15]  Yu Q, Tong S Q, Yan J Z, et al. Preparative separation of quaternary ammonium alkaloids from Corydalis yanhusuo W.-T. Wang by pH-zonerefining counter-current chromatography[J]. J Sep Sci, 2011, 34(3):278.
[16]  俞雁,金艳,徐超.应用高速逆流色谱技术从延胡索中分离制备延胡索乙素[J].世界科学技术--中医药现代化,2006,8(2):17.
[17]  金国章. 中药延胡索研究中的新发现[M].上海:上海科学技术出版社, 2001.
[18]  Chou T Q. The alkaloids of Chinese Corydalis ambigua Cham. et Sch. (Yen-Hu-So) I[J]. Chin J Physiol, 1928, 2:203.
[19]  Chou T Q. The alkaloids of the Chinese Corydalis ambigua Cham et Sch. (Yen-Hu-So). Ⅵ. Identification of corydalis D and corydalis[J]. Chin J Physiol, 1936, 10:507.
[20]  Huang M L. The alkaloids of Chinese Corydalis bulbs (Corydalis ambigua "Yen-Hu-So")[J]. Berichte der Deutschen Chemischen Gesellschaft B: Abhandlungen, 1936, 69B:1737.
[21]  黄鸣龙, 王雪莹. 延胡索生物碱的研究[J]. 中华药学杂志, 1940, 2(1):26.
[22]  赵守训, 徐任生, 朱任宏. 中国延胡索的研究Ⅱ.江苏元胡中的生物碱[J]. 药学学报, 1966, 13:6.
[23]  林子森, 林国英, 高耀良. 延胡索丑素化学结构的测定及其全合成[J]. 复旦学报:自然科学版, 1981, 20(4):446.
[24]  朱大元, 宋纯清, 高耀良, 等. 延胡索己素、壬素、癸素和子素的结构鉴定[J]. 化学学报, 1981, 39(3):280.
[25]  许翔鸿,王峥涛,余国奠,等.延胡索中生物碱成分的研究[J].中国药科大学学报,2002,33(6):483.
[26]  Qu Y, Liu M, Wu Z H, et al. 2, 3, 9, 10-tetraoxygenated protoberberine alkaloids from Corydalis yanhusuo W. T. Wang[J]. Asian J Tradit Med, 2007, 2(2):61.
[27]  胡甜甜,张雪,马世中,等.延胡索中的生物碱成分[J].中国中药杂志,2009,34(15):1917.
[28]  Hu T T, Zhang X, Ma S Z, et al. A new protoberberine alkaloid from Corydalis yanhusuo W. T. Wang[J]. Chin Chem Lett, 2009, 20(8):955.
[29]  Cheng X Y, Shi Y, Zheng S L, et al. Two new protoberberine quaternary alkaloids from Corydalis yanhusuo[J]. J Asian Nat Prod Res, 2008, 10(12):1117.
[30]  Ma Z Z, Xu W, Jensen N H, et al. Isoquinoline alkaloids isolated from Corydalis yanhusuo and their binding affinities at the dopamine D1 receptor[J]. Molecules, 2008, 13(9):2303.
[31]  张晓丽,曲扬,侯家鸣,等.延胡索的化学成分[J].沈阳药科大学学报,2008,25(7):537.
[32]  石俊敏,韩伟立,叶文才,等.延胡索的化学成分研究[J].天然产物研究与开发,2011,23(4):647.
[33]  吕子明,孙武兴,段绪红,等.延胡索化学成分研究[J].中国中药杂志,2012,37(2):235.
[34]  Zhai Z D, Shi Y P, Wu X M, et al. Chiral high-performance liquid chromatographic separation of the enantiomers of tetrahydropalmatine and tetrahydroberberine, isolated from Corydalis yanhusuo[J]. Anal Bioanal Chem, 2006, 384(4):939.
[35]  Ye H Z, Yu L S, Xu X Q, et al. Affinity capillary electrophoresis coupling with partial filling technique and field-amplified sample injection for enantioseparation and determination of DL-tetrahydropalmatine[J]. Electrophoresis, 2010, 31(12):2049.
[36]  Ou J J, Kong L, Pan C S, et al. Determination of DL-tetrahydropalmatine in Corydalis yanhusuo by L-tetrahydropalmatine imprinted monolithic column coupling with reversed-phase high performance liquid chromatography[J]. J Chromatogr A, 2006, 1117(2):163.
[37]  Li W, Yang S B, Pi Z F, et al. Separation and determination of alkaloids in Rhizoma corydalis by capillary zone electrophoresis[J]. J Liq Chromatogr Relat Technol, 2011, 34(12):1050.
[38]  Cheng X Y, Shi Y, Zhen S L, et al. HPLC-MS analysis of ethanol extract of Corydalis yanhusuo and simultaneous determination of eight protoberberine quaternary alkaloids by HPLC-DAD[J]. J Chromatogr Sci, 2010, 48(6):441.
[39]  Ding B, Zhou T T, Fan G R, et al. Qualitative and quantitative determination of ten alkaloids in traditional Chinese medicine Corydalis yanhusuo W.T. Wang by LC-MS/MS and LC-DAD[J]. J Pharm Biomed Anal, 2007, 45(2):219.
[40]  Wang C, Wang S W, Fan G R, et al. Screening of antinociceptive components in Corydalis yanhusuo W.T. Wang by comprehensive two dimensional liquid chromatography/tandem mass spectrometry[J]. Anal Bioanal Chem, 2010, 396(5):1731.
[41]  Li K T, Xing D M, Jin W, et al. Chemical fingerprint and metabolic fingerprint analysis of the medicinal extract of Corydalis yanhusuo by HPLC-UV and HPLC-MS methods[J]. Asian J Chem, 2011, 23(2):723.
[42]  余伯阳, 徐田, 刘吉华. 一种高效生产紫堇达明的生物转化发酵工艺:中国, CN102242164A[P].2011-11-16.
[43]  刘扬子,杨鑫宝,杨秀伟,等.延胡索甲素和乙素的人源肠内菌丛生物转化及在人源Caco-2细胞单层模型的吸收转运[J].中国中药杂志,2013,38(1):112.
[44]  吴佩盛,黄善定,叶亚菊,等.大鼠肠道对左旋延胡索乙素及其消旋体的吸收差异研究[J].药学学报,2007,42(5):534.
[45]  Lei Y, Tan J, Wink M, et al. An isoquinoline alkaloid from the Chinese herbal plant Corydalis yanhusuo W. T. Wang inhibits P-glycoprotein and multidrug resistance-associate protein 1[J]. Food Chem, 2013, 136(3/4):1117.
[46]  程星烨,石钺,孙虹,等.延胡索活性部位入血成分的LC-MS/MS 研究[J].药学学报,2009,44(2):167.
[47]  Hong Z Y, Zhao L, Wang X L, et al. High-performance liquid chromatography-time-of-flight mass spectrometry with adjustment of fragmentor voltages for rapid identification of alkaloids in rat plasma after oral administration of rhizoma Corydalis extracts[J]. J Sep Sci, 2012, 35(13):1690.
[48]  Hong Z Y, Fan G R, Le J, et al. Brain pharmacokinetics and tissue distribution of tetrahydropalmatine enantiomers in rats after oral administration of the racemate[J]. Biopharm Drug Dispos, 2006, 27(3):111.
[49]  Zhao Y, Hellum B H, Liang A H, et al. The in vitro inhibition of human CYP1A2, CYP2D6 and CYP3A4 by tetrahydropalmatine, neferine and berberine[J]. Phytother Res, 2012, 26(2):277.
[50]  Sun S Y, Wang Y Q, Li L P, et al. Stereoselective interaction between tetrahydropalmatine enantiomers and CYP enzymes in human liver microsomes[J]. Chirality, 2013, 25(1):43.
[51]  Zhao M, Li L P, Sun D L, et al. Stereoselective metabolism of tetrahydropalmatine enantiomers in rat liver microsomes[J]. Chirality, 2012, 24(5):368.
[52]  Zhang M Y, Le J, Wen J, et al. Simultaneous determination of tetrahydropalmatine and tetrahydroberberine in rat urine using dispersive liquid-liquid microextraction coupled with high-performance liquid chromatography[J]. J Sep Sci, 2011, 34(22):3279.
[53]  Hong Z Y, Wen J, Zhang Q L, et al. Study on the stereoselective excretion of tetrahydropalmatine enantiomers in rats and identification of in vivo metabolites by liquid chromatography-tandem mass spectrometry[J]. Chirality, 2010, 22(3):355.
[54]  Li L, Ye M, Bi K S, et al. Liquid chromatography-tandem mass spectrometry for the identification of L-tetrahydropalmatine metabolites in Penicillium janthinellum and rats[J]. Biomed Chromatogr, 2006, 20(1):95.
[55]  Sun D L, Huang S D, Wu P S, et al. Stereoselective protein binding of tetrahydropalmatine enantiomers in human plasma, HSA, and AGP, but not in rat plasma[J]. Chirality, 2010, 22(6):618.
[56]  林力,刘建勋,张颖,等. LC-MS/MS法测定大鼠口服延胡索提取物后延胡索乙素和脱氢紫堇碱的药代动力学[J].药学学报,2008,43(11):1123.
[57]  胡楠,梁日欣,王岚,等.延胡索提取物在大鼠血浆中的药代动力学研究[J].中国实验方剂学杂志,2011,17(4):186.
[58]  Zhang Y Y, Shi K, Wen J, et al. Chiral HPLC determination and stereoselective pharmacokinetics of tetrahydroberberine enantiomers in rats[J]. Chirality, 2012, 24(3):239.
[59]  Hong Z Y, Fan G R, Chai Y F, et al. Stereoselective pharmacokinetics of tetrahydropalmatine after oral administration of (-)-enantiomer and the racemate[J]. Chirality, 2005, 17(5):293.
[60]  Hong Z Y, Le J, Lin M, et al. Comparative studies on pharmacokinetic fates of tetrahydropalmatine enantiomers in different chemical environments in rats[J]. Chirality, 2008, 20(2):119.
[61]  胡甜甜,张雪,马世中,等.延胡素中的生物碱成分[J].中国中药杂志,2009,34(15):1917.
[62]  杨征, 余伯阳, 张剑, 等. 四氢小檗红碱制备用于抗焦虑、抗抑郁用途的药物:中国, CN101972252A[P]. 2011-02-16.
[63]  杨秀伟.基于体内过程的中药有效成分和有效效应物质的发现策略[J].中国中药杂志,2007,32(5):365.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133