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辛香料挥发油类化学成分的新型载体系统研究进展

Keywords: 辛香料挥发油,化学成分,新型载体系统,稳定性

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Abstract:

近年来,辛香料挥发油类化学成分因诸多药理活性,尤其是作为安全可食用的天然抗菌剂引起了许多学者的广泛关注。而辛香料挥发油类化学成分普遍具有几乎不溶于水、刺激性大、挥发性强、稳定性差、易氧化、生物利用度低等缺点,在很大程度上限制了其在口服制剂开发及临床应用等方面的发展。因此针对辛香料挥发油类化学成分的上述特性,通过选择合适的制剂学手段,筛选出既能高效传递辛香料挥发油类化学成分还能在一定程度上提高其稳定性及缓解其刺激性的新型药物载体系统,进而开发能充分发挥各自药理活性的功能性食品、保健品乃至具有较好临床效果的药品,是其应用研究的热点与难点方向。该文就环糊精包合物、脂质体、纳米乳、纳米粒和固体分散体等新型载体系统在辛香料挥发油类化学成分中的研究应用进行综述,并概述了每一种新型载体系统各具有的特点、适用的对象及存在的问题等,为进一步开发辛香料挥发油类化学成分的新产品提供参考与借鉴。

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