Kanmoto T, Mimaki Y, Saxida Y, et al. Steroidal constituents from the underground of Reineckea camera and their inhibitory activity on cAMP Phosphodiesterase[J]. Chem Pharm Bull (Tokyo), 1994, 42(4): 926.
[2]
Nakaruma O, Mimaki Y, Saxida Y, et al. Agapanthussaponins A-D,new potent cAMP phosphodiesterase inhibitors from the underground parts of Agapanthus inapertus[J]. Chem Pharm Bull, 1993, 41(10) : 1784.
[3]
Yang C R, Zhang Y, Melissa R, et al. Antifungal activity of C-27 steroidal saponins[J]. Antimicrob Agents Chemother, 2006, 50: 1710.
[4]
Barile E, Bonanomi G, Antignani V, et al. Saponins from Allium minutiflorum with antiflingal activity[J]. Phytochemistry, 2007, 68: 596.
[5]
Zhang J D, Cao Y B, Xu Z, et al.In vitro and in vivo antifungal activities of the eight steroid saponins from Tribulus terrestris L with potent activity against fluconazole-resistant fungal pathogens[J]. Biol Pharm Bull, 2005, 28: 2211.
[6]
Zhang Y, Zhang Y J, Melissa R J, et al. Steroidal saponins from the stem of Yucca elephantipes[J]. Phytochemistry, 2008, 69: 264.
[7]
Delucca A J,Bland J M, Vigo C B. CAY-I, a fungicidal saponin from Capsicum sp. fruit[J]. Med Mycol, 2002, 40: 131.
Ling Y, Teng F J, Ai G W, et a1. Two new furostanol saponins from the seeds of Allimn cepa L[J]. Chin Chem Lett, 2008, 19(4): 461.
[11]
Tam K I, Roner M R. Characterization of in vivo anti-rotavirus activities of saponin extracts from Quillaja saponaria Molina[J]. Antiviral Res, 2011, 90(3): 231.
[12]
Zolfaghari B, Barile E, Capasso R, et al. The sapogenin A troviolacegenin and its diglycoside atroviolaceoside fromAllium atro wiolaceum[J]. J Nat Prod, 2006, 69 (2): 191.
[13]
Corea G, Fattorusso E, Lanzotti V. Antispasmodic saponins from bulbs of red onion, AlliumcepaL. var. Tropea[J]. J Agric Food Chem, 2005, 53: 935.
[14]
Ori K, Mimaki Y, Mito K, et al. Jatropham derivatives and steroidal saponins from the bulbs ofLilium hansonii[J]. Phytochemistry, 1992, 31(8) : 2767.
[15]
甾体皂苷防止AD的用途及新的甾体皂苷: 中国. 97119680[P]. 1999.
[16]
Elekofehinti O O, Omotuyi O I, Kamdem J P, et al. Saponin as regulator of biofuel: implication for ethnobotanical management of diabetes[J]. J Physiol Biochem, 2014, 70(2): 555.
[17]
Yoshikawa M, Xu F M, Morikawa T. Medicinal flowers. XII. new spirostane-type steroid saponins with antidiabetogenic activity from Borassus flabellifer[J]. Chem Pharm Bull, 2007, 55: 308.
[18]
Gong G H, Qin Y, Huang W, et al. Protective effects of diosgenin in the hyperlipidemic rat model and in human vascular endothelial cells against hydrogen peroxide-induced apoptosis[J]. Chem Bio Interact, 2010, 184: 366.
[19]
Xie W D, Zhang Y, Wang N L, et al. Novel effects of macrostemonoside A, a compound from Allium macrostemon Bung, on hyperglycemia, hyperlipidemia, and visceral obesity in high-fat C57BL/6 mice[J]. Eur J Pharm, 2008, 599: 159.
[20]
Son I S, Kim J H, Sohn H Y, et al. Antioxidative and hypolipidemic effects of diosgenin, a steroidal saponin of Yam (Dioscorea spp.) on high-cholesterol fed rats[J]. Biosci Biotechnol Biochem, 2014, 71(12): 3063.
Gabler N K, Osrowsk A E, Imsic M, et al. Dietary onion intake as part of a typical high fat diet improves indices of cardiovascular healih using the mixed sex pig model[J]. Plant Foods Hmn Nutr, 2006, 61 (4): 179.
[23]
Sautour M, A Mitaine-Offer, M Lacaille-Dubois. The Dioscorea genus: a review of bioactive steroid saponins[J]. J Nat Med, 2007,61(2): 91.
Chang Tsu-Chung, Huang S F, Yang T C, et al. Effect of ginsenosides on glucose uptake in human Caco-2 cells is mediated through altered Na+/glucose cotransporter 1 expression[J]. J Agric Food Chem, 2007, 55: 1993.
[26]
Kostova I, D Dinchev. Saponins inTribulus terrestris-chemistry and bioactivity[J]. Phytochem Rev, 2005, 4: 111.
[27]
Eskander J Y, Haggag E G, El-Gindi M R, et al. A novel saponin from Manilkara hexandra seeds and anti-inflammatory activity[J]. Med Chem Res, 2014, 23(2): 717.
[28]
Lunga P K, Qin X J, Yang X W, et al. Antimicrobial steroidal saponin and oleanane-type triterpenoid saponins from Paullinia pinnata[J]. BMC Complement Alternat Med, 2014, 14: 369.
Sharma U, Kumar N, Singh B, et al. Immunomodulatory active steroidal saponins from Asparagus racemosus[J]. Med Chem Res, 2013, 22(2): 573.
[32]
Ali N, Shah S W A, Shah I, et al. Cytotoxic and anthelmintic potential of crude saponins isolated from Achillea Wilhelmsii C. Koch andTeucrium stocksianum boiss[J]. BMC Complement Alternat Med, 2011, 11: 106.
[33]
Wang G X, Jiang D X, Li J, et al. Anthelmintic activity of steroidal saponins from Dioscorea zingiberensis C. H. Wright against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus) [J]. Parasitol Res, 2010, 107(6): 1365.
[34]
Wang G X, Han J, Zhao L W, et al. Anthelmintic activity of steroidal saponins from Paris polyphylla[J]. Phytomedicine, 2010, 77: 1102.
[35]
Regalado E L, Tasdemir D, Kaiser M. Antiprotozoal steroidal saponins from the marine sponge Pandaros acanthifolium[J]. J Nat Prod, 2010, 75: 1404.
[36]
吴立军.天然药物化学[M].5版,北京: 人民卫生出版社,2009: 333.
[37]
Liu M J, Wang Z, Ju Y, et al. Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis[J]. Cancer Chemother Pharmacol, 2005, 55(1): 79.
[38]
Sobolewska D, Michalska K, Podolak I, et al. Steroidal saponins from the genus Allium[J]. Phytochem Rev, 2014,doi: 10.1007/s11101-014-9381-1.
[39]
Tong Q Y, Qing Y, Shu D, et al. Deltonin,a steroidal saponin, inhibits colon cancer cell growthin vitro and tumor growth in vivo via induction of apoptosis and antiangiogenesis[J]. Cell Physiol Biochem, 2011, 27(3/4): 233.
[40]
Eskander J, Sakka O K, Harakatet D, et al. Steroidal saponins from the leaves of Yucca de-smetianaand their in vitro antitumor activity: structure activity relationships through a molecular modeling approach[J]. Med Chem Res, 2013, 22(10): 4877.
[41]
Yokosuka A, Mimaki Y. Steroidal saponins from the whole plants of Agave utahensis and their cytotoxic activity[J]. Phytochemistry, 2009,70: 807.
Wu J J, Cheng K W, Zuo X F, et al. Steroidal saponins and ecdysterone from Asparagus filicinus and their cytotoxic activities[J]. Steroids, 2010, 75: 734.
[45]
Elie B Y, Shimon B S, Noa G, et al. Antiproliferative activity of steroidal saponins from Balanites aegyptiaca-anin vitro study[J]. Phytochem Lett, 2011, 4: 4347.
Zhou Y, Celia G P, Dennis A C, et al. OSW-1: a natural compound with potent anticancer activity and a novel mechanism of action[J]. J Natl Cancer Inst, 2005, 97: 1781.
[49]
Ohtsuki T,Sato M,Koyano T, et al. Steroidal saponins fromCalamus insignis and their cell growth and cell cycle inhibitory activities [J]. Bioorg Med Chem, 2006, 14: 659.
[50]
Xu Q M, Shu Z, He W J, et al. Antitumoractivity of Pulsatilla chinensis(Bunge) regelsaponins in human liver tumor 7402 cells in vitroand in vivo[J]. Phytomedicine, 2012, 19: 293.
[51]
Man S L, Gao W Y, Zhang Y Z, et al. Paridis saponins inhibiting carcinoma growth and metastasisin vitro and in vivo[J]. Arch Pharm Res, 2011,34(1): 43.
Eskander J Y, Eskander E G, Haggag M R, et al. A novel saponin from Manilkara hexandra seeds and anti-inflammatory activity[J]. Med Chem Res, 2014, 23(2): 717.
[56]
Lee S J, Bae J, Kim S, et al. Saponins from soy bean and mung bean inhibit the antigen specific activation of helper T cells by blocking cell cycle progression[J]. Biotechn Lett, 2013, 35(2): 165.
[57]
Tapondjou L A, Ponou K B, Teponno R B, et al. In vivo anti-inflammatory effect of a new steroidal saponin, mannioside A,and its derivatives isolated from Dracaena mannii[J]. Arch Pharm Res, 2008, 37: 653.
[58]
Adao C R, Silva B P D,Parente J P, et al. A new steroidal saponin from Allium ampeloprasumvar. porrumwith anti-inflammatory and gastroprotective effects [J]. Phytochem Lett, 2011, 4: 306.
[59]
Adao C R, Silva B P D, Parente J P. A new steroidal saponin with antiinflammatory and antiulcerogenic properties from the bulbs of Allium ampeloprasumvar. porrum[J]. Fitoterapia, 2011, 82: 1175.
[60]
Diniz L R L, Portella V G, Cardoso F M, et al. The effect of saponins from Ampelozizyphus amazonicusDucke on the renal Na+ pumps\' activities and urinary excretion of natriuretic peptides[J]. BMC Complement Alternat Med, 2012, 12: 40.
0da K, Matsuda H, Murakami T, et al. Adjuvant and haemolytic activities of 47 saponins derived from medicinal and food plants[J]. Biol Chem, 2000, 381: 67.
[63]
Erik L, Regalado, Tom Turk, et al. Cytotoxic and haemolytic steroidal glycosides from the Caribbean spongePandaros acanthifolium[J]. Steroids, 2011, 7(5) : 1389.
[64]
Wang Y B, Zhang Y C, Zhu Z Y, et al. Exploration of the correlation between the structure, hemolytic activity,and cytotoxicity of steroid saponins[J]. Bioorg Med Chem, 2007, 15: 2528.
[65]
Lai W, Wu Z J, Lin H W, et al. Anti-ischemia steroidal saponins from the seeds of Allium fistulosum[J]. J Nat Prod, 2010, 75: 1053.
Li H, Huang W, Wen Y, et al. Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C. H. Wright[J]. Fitoterapia, 2010, 81( 8): 1147.
[69]
Zhang R, Huang B, Du D, et al. Anti-thrombosis effect of diosgenyl saponins in vitro and in vivo[J]. Steroids, 2013, 78( 11): 1064.
