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蜘蛛香中的环烯醚萜类成分及其生物活性研究进展

Keywords: 蜘蛛香,环烯醚萜,药理活性,作用机制

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Abstract:

蜘蛛香Valerianajatamansi不但为中国的传统中药,1977年和2010年版《中国药典》一部曾加以收载,同时也是欧洲缬草V.officinalis的重要的替代品之一。蜘蛛香的地下部位提取物在欧洲作为温和镇静剂由来已久,也是缬草制剂的主要商业来源之一。环烯醚萜类(缬草三酯类)为蜘蛛香主要有效成分之一,近年来不断从蜘蛛香中发现了大量新的环烯醚萜成分,并显示出显著的抗肿瘤、抗焦虑和治疗肠胃疾病的活性,相关的作用机制研究也受到广泛关注。该文对蜘蛛香中发现的的环烯醚萜类成分及其药理活性进行了综述,以期为蜘蛛香的研究与开发提供可借鉴的依据。

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