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黄连素对2型糖尿病及其并发症的治疗作用及相关机制研究进展

Keywords: 黄连素,2型糖尿病,胰岛素,糖尿病并发症

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Abstract:

黄连素(berberine,BBR)是从黄连CoptidisRhizoma、黄柏PhellodendriChinensisCortex等中药中提取出的一种生物碱.该类中药用以治疗细菌性胃肠炎、痢疾等消化道疾病已有上千年的历史.近年研究表明,黄连素具有降血糖、血脂,抗炎,抗氧化等多种药理作用;并对2型糖尿病及糖尿病性肾病(diabeticnephropathy,DN)、糖尿病性心血管疾病、糖尿病周围神经病变(diabeticperipheralneuropathy,DPN)等糖尿病并发症有较好的缓解及保护作用.文章就黄连素降血糖和防治上述2型糖尿病并发症方面的文献报道进行简要综述,为进一步研究和推广黄连素的应用提供参考.

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