全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

桂枝茯苓方治疗痛经、盆腔炎以及子宫肌瘤的活性成分和分子作用机制研究

Keywords: 中药,网络药理学,分子对接,痛经,盆腔炎,子宫肌瘤

Full-Text   Cite this paper   Add to My Lib

Abstract:

该研究采用网络药理学的方法,探讨桂枝茯苓方治疗痛经、盆腔炎以及子宫肌瘤的主要活性成分和潜在的分子作用机制。药物-靶点网络特征分析显示分子网络度较高的多为甾醇类和五环三萜类化合物,它们在抗炎、解热镇痛、抗肿瘤以及免疫调节等方面具有较好的治疗作用;另一方面网络度较高的靶点多与炎症反应、凝血系统、血管形成、平滑肌收缩以及细胞增殖等环节有关。进一步的靶点-通路网络分析结果显示这些靶点与调控子宫平滑肌增殖、抑制子宫内新生血管形成、改善血液循环、降低性激素分泌、缓解子宫平滑肌收缩、抑制花生四烯酸代谢以及其他炎症反应等6个环节密切相关,从而揭示出其治疗痛经、盆腔炎以及子宫肌瘤的主要分子机制。该研究表明桂枝茯苓方可通过多个活性成分作用于多个靶点,调控21条生物通路,来治疗盆腔炎、痛经及子宫肌瘤。

References

[1]  宋俊生, 高岑, 熊俊, 等. 桂枝茯苓胶囊与西药治疗子宫肌瘤疗效比较的系统评价[J]. 中国循证医学杂志, 2010, 10(12):1439.
[2]  颜惠琦. 超激光联合桂枝茯苓胶囊治疗慢性盆腔炎的疗效观察[J]. 现代医药卫生, 2011, 27(23):3562.
[3]  秦泗涟, 马利华, 贾晓斌, 等. 桂枝茯苓方物质基础及其制剂质量控制模式研究进展[J]. 中国实验方剂学杂志, 2011(13):270.
[4]  Tao W, Xu X, Wang X, et al. Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease[J]. J Ethnopharmacol, 2013, 145(1):1.
[5]  O\'boyle N M, Banck M, James C A, et al. Open babel:an open chemical toolbox[J]. J Cheminform, 2011, 3:33.
[6]  Jabbour H N, Sales K J. Prostaglandin receptor signalling and function in human endometrial pathology[J]. Trends Endocrinol Metab, 2004, 15(8):398.
[7]  Edwards A K, Nakamura D S, Virani S, et al. Animal models for anti-angiogenic therapy in endometriosis[J]. J Reprod Immunol, 2013, 97(1):85.
[8]  Islam M S, Akhtar M M, Ciavattini A, et al. Use of dietary phytochemicals to target inflammation, fibrosis, proliferation, and angiogenesis in uterine tissues:promising options for prevention and treatment of uterine fibroids?[J]. Mol Nutr Food Res, 2014, 58(8):1667.
[9]  Wu M H, Lu C W, Chuang P C, et al. Prostaglandin E2:the master of endometriosis?[J]. Exp Biol Med, 2010, 235(6):668.
[10]  Jabbour H N, Sales K J, Smith O P M, et al. Prostaglandin receptors are mediators of vascular function in endometrial pathologies[J]. Mol Cell Endocrinol, 2006, 252(1/2):191.
[11]  Taylor D K, Leppert P C. Treatment for uterine fibroids:searching for effective drug therapies[J]. Drug Discov Today, 2012, 9(1):e41.
[12]  Maybin J A, Critchley H O D, Jabbour H N. Inflammatory pathways in endometrial disorders[J]. Mol Cell Endocrinol, 2011, 335(1):42.
[13]  Zhao L, Yang H, Xuan Y, et al. Increased expression of fibroblast growth factor receptor 1 in endometriosis and its correlation with endometriosis-related dysmenorrhea and recurrence[J]. Eur J Obstet Gynecol Reprod Biol, 2015,184:117.
[14]  Kelly R W, King A E, Critchley H O. Cytokine control in human endometrium[J]. Reproduction, 2001, 121(1):3.
[15]  Marret H, Fritel X, Ouldamer L, et al. Therapeutic management of uterine fibroid tumors:updated French guidelines[J]. Eur J Obstet Gynecol Reprod Biol, 2012, 165(2):156.
[16]  Jiang X, Kumar K, Hu X, et al. DOVIS 2.0:an efficient and easy to use parallel virtual screening tool based on AutoDock 4.0[J]. Chem Cent J, 2008, 2:18.
[17]  张新庄, 萧伟, 徐筱杰, 等. 利用网络药理学方法研究热毒宁注射液抗流感病毒的分子作用机制[J]. 物理化学学报, 2013(7):1415.
[18]  Kanehisa M, Goto S, Furumichi M, et al. KEGG for representation and analysis of molecular networks involving diseases and drugs[J]. Nucleic Acids Res, 2010, 38:D355.
[19]  Smoot M E, Ono K, Ruscheinski J, et al. Cytoscape 2.8:new features for data integration and network visualization[J]. Bioinformatics, 2011, 27(3):431.
[20]  Saito R, Smoot M E, O?? K, et al. A travel guide to cytoscape plugins[J]. Nat Methods, 2012, 9(11):1069.
[21]  Barabási A L. Scale-free networks:a decade and beyond[J]. Science, 2009, 325(5939):412.
[22]  Xu X, Luo J W, Gu Y T. Collective dynamics and control of a 3-D small-world network with time delays[J]. Int J Bifurcat Chaos, 2012, 22(11):1250281.
[23]  Zhou W X, Cheng X R, Zhang Y X. Network pharmacology——a new philosophy for understanding of drug action and discovery of new drugs[J]. Chin J Pharmacol Toxicol, 2012, 26(1):4.
[24]  谢心美, 郝海鑫, 何剑斌. 植物甾醇的生理功能及其应用[J]. 草业科学, 2013(12):2105.
[25]  孟艳秋, 赵临襄, 王趱, 等. 五环三萜类化合物的构效关系[J]. 中国新药杂志, 2004 (12):30.
[26]  程晓华, 熊玉卿. 五环三萜皂苷的药理作用研究进展[J]. 中草药, 2007(5):792.
[27]  Howard F M. Endometriosis and mechanisms of pelvic pain[J]. J Minim Invas Gyn, 2009, 16(5):540.
[28]  Sioutas A, Ehrén I, Lundberg J O, et al. Intrauterine nitric oxide in pelvic inflammatory disease[J]. Fertil Steril, 2008, 89(4):948.
[29]  Sun M F, Huang H C, Lin S C, et al. Evaluation of nitric oxide and homocysteine levels in primary dysmenorrheal women in Taiwan[J]. Life Sci, 2005, 76(17):2005.
[30]  Wilhelmsson L, Lindblom B, Wikland M, et al. PGI2 may play a role in the pathophysiology of dysmenorrhea[J]. Acta Obstet Gynecol Scand Suppl, 1983, 113:69.
[31]  Koohestani F, Mcwilliams M M, Wertenberger R A, et al. WNT and mTOR pathways in the G-protein coupled receptor 10 (GPR10) transgenic mouse model of uterine fibroids[J]. Ferti Steril, 2014, 102(3Supplement):e3.
[32]  Bakas P, Liapis A, Vlahopoulos S, et al. Estrogen receptor α and β in uterine fibroids:a basis for altered estrogen responsiveness[J]. Fertil Steril, 2008, 90(5):1878.
[33]  Chwalisz K, Perez M C, Demanno D, et al. Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis[J]. Endocr Rev, 2005, 26(3):423.
[34]  Kilic I, Oksuz-Kanbur N, Derman O, et al. Role of leukotrienes in the pathogenesis of dysmenorrhea in adolescent girls[J]. Turk J Pediatr, 2008, 50(6):52

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133