全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

基于同源基因功能分化的药用植物活性成分变异机制研究

Keywords: 基因复制,功能分化,活性成分,变异

Full-Text   Cite this paper   Add to My Lib

Abstract:

在中药材质量控制研究领域,药用植物活性成分变异机制研究始终是重点和热点问题。随着高通量测序技术的发展和成本的降低,大量药用植物基因序列克隆为进一步研究基因序列的遗传信息与其所执行的生物学功能奠定了基础,也为从分子生药学角度探索药材活性成分变异及其质量控制提供了有力条件。该文详细介绍了同源基因、基因重复的概念和分类,并重点展望了重复基因功能分化在药用植物活性成分变异分子机制研究中的作用,旨在为药材质量控制基础研究提供新的思路。

References

[1]  Edger P P, Pires J C. Gene and genome duplications: the impact of dosage-sensitivity on the fate of nuclear genes[J]. Chromosome Res, 2009, 17(5): 699.
[2]  Freeling M, Thomas B C. Gene-balanced duplications, like tetraploidy, provide predictable drive to increase morphological complexity[J]. Genome Res, 2006, 16(7): 805.
[3]  Li W H, Yang J, Gu X. Expression divergence between duplicate genes[J]. Trends Genet, 2005, 21(11): 602.
[4]  孙红正, 葛颂. 重复基因的进化——回顾与进展[J]. 植物学报, 2010, 45(1): 13.
[5]  Ferris S D, Whitt G S. Evolution of the differential regulation of duplicate genes after polyploidization[J]. J Mol Evol, 1979, 12(4): 267.
[6]  Hanada K, Zou C, Lehti-Shiu M D, et al. Importance of lineage-specific expansion of plant tandem duplicates in the adaptive response to environmental stimuli[J]. Plant Physiol, 2008, 148(2): 993.
[7]  Force A, Lynch M, Pickett F B, et al. Preservation of duplicate genes by complementary, degenerative mutations[J]. Genetics, 1999, 151(4): 1531.
[8]  Lynch M, Conery J S. The evolutionary fate and consequences of duplicate genes[J]. Science, 2000, 290(5494): 1151.
[9]  Papp B, Pál C, Hurst L D. Evolution of cis-regulatory elements in duplicated genes of yeast[J]. Tren Gene, 2003, 19(8): 417.
[10]  Chen F, Mackey A J, Vermunt J K, et al. Assessing performance of orthology detection strategies applied to eukaryotic genomes[J]. PLoS ONE, 2007, 2(4): e383.
[11]  潘增祥, 许丹, 张金璧, 等. 基于直向同源序列的比较基因组学研究[J]. 遗传, 2009, 31(5): 457.
[12]  Conte M G, Gaillard S, Droc G, et al. Phylogenomics of plant genomes: a methodology for genome-wide searches for orthologs in plants[J]. BMC Genomics, 2008, 9(1): 183.
[13]  Sennblad B, Lagergren J. Probabilistic orthology analysis[J]. Syst Biol, 2009, 58(4): 411.
[14]  Altenhoff A M, Dessimoz C. Phylogenetic and functional assessment of orthologs inference projects and methods[J]. PLoS Comput Biol, 2009, 5(1): e1000262.
[15]  Ohta T. Evolution by gene duplication revisited: differentiation of regulatory elements versus proteins[J]. Genetica, 2003, 118(2/3): 209.
[16]  Hakes L, Pinney J W, Lovell S C, et al. All duplicates are not equal: the difference between small-scale and genome duplication[J]. Genome Biol, 2007, 8(10): R209.
[17]  李昕, 杨爽, 彭立新, 等. 新基因的起源与进化[J]. 科学通报, 2004, 49(13): 1219.
[18]  Zhang J. Evolution by gene duplication: an update[J]. Trend Ecol Evolut, 2003, 18(6): 292.
[19]  He X, Zhang J. Rapid subfunctionalization accompanied by prolonged and substantial neofunctionalization in duplicate gene evolution[J]. Genetics, 2005, 169(2): 1157.
[20]  彭华胜,王德群.赤芍白芍划分的本草学源流[J].中华医史杂志,2007,37(3):133.
[21]  Yuan Y, Yu J, Jiang C, et al. Functional diversity of genes for the biosynthesis of paeoniflorin and its derivatives in Paeonia[J]. Int J Mol Sci, 2013, 14(9): 18502.
[22]  Yuan Y, Song L, Li M, et al. Genetic variation and metabolic pathway intricacy govern the active compound content and quality of the Chinese medicinal plant Lonicera japonica Thunb[J]. BMC Genomics, 2012, 13(1): 195.
[23]  Yuan Y, Yu S, Yu J, et al. Predicting the function of 4-coumarate:CoA Ligase(LJ4CL1) in Lonicera japonica[J]. Int J Mol Sci, 2014, 15(2): 2386.
[24]  Yuan Y, Wang Z, Jiang C. Exploiting genes and functional diversity of chlorogenic acid and luteolin biosyntheses in Lonicera japonica and their substitutes[J]. Gene,2014,534(2):408.
[25]  秦双双,黄璐琦,袁媛. 华南忍冬绿原酸和木犀草素生物合成关键酶基因表达分析[J]. 中国中药杂志, 2014, 39(13):2469.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133