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配伍甘草对大黄泻下作用影响的研究进展

Keywords: 大黄,甘草,配伍,代谢

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Abstract:

大黄是一味常用大宗药材,临床上配伍应用非常广泛.蒽醌类物质为其泻下作用主要活性成分,中医认为大黄泻下峻猛为大黄的毒性.有着"国老"美誉的甘草,一直被认为是解毒圣药,缓和药性,调和诸药.该文将大黄配伍甘草减毒作用分为煎煮过程、肠道代谢2个环节,分别从化学成分、肠道菌群、Ⅰ/Ⅱ相代谢、药物转运方面综述近年来大黄配伍甘草减毒的研究进展.二者配伍的物质基础和机制仍不完全清楚,甚至有相左的结果出现,有待深入研究.

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