Michihara S, Tanaka T, Uzawa Y, et al. Puerarin exerted anti-osteoporotic action independent of estrogen receptor-mediated pathway[J].J Nutr Sci Vitaminol (Tokyo),2012,58(3):202.
[5]
Priya Batra, Anil K Sharma. Anti-cancer potential of flavonoids: recent trends and future perspectives[J]. Biotech,2013,3(6):439.
[6]
Mateen S, Raina K, Agarwal R. Chemopreventive and anti-cancer efficacy of silibinin against growth and progression of lung cancer[J].Nutr Cancer,2013,65 (Suppl1):3.
[7]
Li Y, Ma C, Qian M, et al. Butein induces cell apoptosis and inhibition of cyclooxygenase-2 expression in A549 lung cancer cells[J].Mol Med Rep,2014,9(2):763.
[8]
Lirdprapamongkol K, Sakurai H, Abdelhamed S, et al. A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells[J].Oncol Rep,2013,30(5):2357.
[9]
Wang L M, Xie K P, Huo H N, et al. Luteolin inhibits proliferation induced by IGF-1 pathway dependent ERα in human breast cancer MCF-7 cells[J].Asian Pac J Cancer Prev,2012,13(4):1431.
[10]
Yiannakopoulou E Ch. Effect of green tea catechins on breast carcinogenesis: a systematic review of in vitro and in vivo experimental studies[J].Eur J Cancer Prev,2014,23(2):84.
[11]
Forghani P, Khorramizadeh M R, Waller E K. Silibinin inhibits accumulation of myeloid-derived suppressor cells and tumor growth of murine breast cancer[J].Cancer Med,2014,3(2):215.
[12]
Pan D, Li W, Miao H, et al. LW-214, a newly synthesized flavonoid, induces intrinsic apoptosis pathway by down-regulating Trx-1 in MCF-7 human breast cells[J].Biochem Pharmacol,2014,87(4):598.
[13]
Akhtar R, Ali M, Mahmood S, et al. Anti-proliferative action of silibinin on human colon adenomatous cancer HT-29 cells[J]. Nutr Hosp,2014,29(2):388.
[14]
Pandurangan A K, Dharmalingam P, Sadagopan S K, et al. Luteolin induces growth arrest in colon cancer cells through involvement of Wnt/β-catenin/GSK-3β signaling[J].J Environ Pathol Toxicol Oncol,2013,32(2):131.
[15]
Kim D H, Hossain M A, Kang Y J, et al. Baicalein,an active component of Scutellaria baicalensis Georgi, induces apoptosis in human colon cancer cells and prevents AOM/DSS-induced colon cancer in mice[J].Int J Oncol,2013,43(5):1652.
[16]
Wang Y, Ma Y, Zheng Y, et al. In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer, with high efficacy and low toxicity[J].Int Pharm,2013,441(1/2):728.
[17]
Sharmila G, Bhat F A, Arunkumar R, et al. Chemopreventive effect of quercetin, a natural dietary flavonoid on prostate cancer in in vivo model[J].Clin Nutr,2014,33(4):718.
[18]
Kim H R, Park C G, Jung J Y. Acacetin(5,7-dihydroxy-4\'-methoxyflavone)exhibits in vitro and in vivo anticancer activity through the suppression of NF-κB/Akt signaling in prostate cancer cells[J].Int J Mol Med,2014,33(2):317.
[19]
Mahmoud A M, Yang W, Bosland M C. Soy isoflavones and prostate cancer: a review of molecular mechanisms[J].J Steroid Biochem Mol Biol,2014,140:116.
[20]
Solmaz S, Gokbulut A, Cincin B, et al. Therapeutic potential of apigenin, a plant flavonoid, for imatinib-sensitive and resistant chronic myeloid leukemia cells[J].Nutr Cancer,2014,66(4):599.
[21]
Lin C C, Lin J J, Wu P P, et al. Wogonin, a natural and biologically-active flavonoid, influences a murine WEHI-3 leukemia model in vivo through enhancing populations of T- and B-cells[J]. In Vivo,2013,27(6):733.
[22]
Huang G, Tang B, Tang K, et al. Isoquercitrin inhibits the progression of liver cancer in vivo and in vitro via the MAPK signalling pathway[J].Oncol Rep,2014,31(5):2377.
[23]
Feng L L, Liu B X, Zhong J Y, et al. Effect of grape procyanidins on tumor angiogenesis in liver cancer xenograft models[J]. Asian Pac J Cancer Prev,2014,15(2):737.
[24]
Hwang Y J, Lee E J, Kim H R, et al. Molecular mechanisms of luteolin-7-O-glucoside-induced growth inhibition on human liver cancer cells: G2/M cell cycle arrest and caspase-independent apoptotic signaling pathways[J].BMB Rep,2013,46(12):611.
[25]
Hwang K A, Park M A, Kang N H, et al. Anticancer effect of genistein on BG-1 ovarian cancer growth induced by 17 β-estradiol or bisphenol A via the suppression of the crosstalk between estrogen receptor α and insulin-like growth factor-1 receptor signaling pathways[J].Toxicol Appl Pharmacol,2013,272(3):637.
[26]
Yi L, Zongyuan Y, Cheng G, et al. Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pathway[J].Cancer Sci,2014,105(5):520.
[27]
Chen J, Li Z, Chen A Y, et al .Inhibitory effect of baicalin and baicalein on ovarian cancer cells[J].Int J Mol Sci,2013,14(3):6012.
[28]
He J, Xu Q, Wang M, et al. Oral administration of apigenin inhibits metastasis through AKT/P70S6K1/MMP-9 pathway in orthotopic ovarian tumor model[J]. Int J Mol Sci,2012,13(6):7271.
[29]
Cho H J, Suh D S, Moon S H, et al. Silibinin inhibits tumor growth through downregulation of extracellular signal-regulated kinase and Akt in vitro and in vivo in human ovarian cancer cells[J].J Agric Food Chem, 2013,61(17):4089.
[30]
Kuo C H, Weng B C, Wu C C, et al. Apigenin has anti-atrophic gastritis and anti-gastric cancer progression effects in helicobacter pylori-infected Mongolian gerbils[J].J Ethnopharmacol,2014,151(3):1031.
[31]
Moon J Y, Cho M, Ahn K S, et al. Nobiletin induces apoptosis and potentiates the effects of the anticancer drug 5-fluorouracil in p53-mutated SNU-16 human gastric cancer cells[J].Nutr Cancer,2013,65(2):286.
[32]
Yan G R, Zou F Y, Dang B L, et al. Genistein-induced mitotic arrest of gastric cancer cells by downregulating KIF20A,a proteomics study[J]. Proteomics,2012,12(14):2391.
Wang Z, Lu W, Li Y, et al. Alpinetin promotes Bax translocation, induces apoptosis through the mitochondrial pathway and arrests human gastric cancer cells at the G2/M phase[J].Mol Med Rep,2013,7(3):915.
[35]
Park B B, Yoon Js, Kim Es, et al. Inhibitory effects of eupatilin on tumor invasion of human gastric cancer MKN-1 cells[J]. Tumour Biol,2013,34(2):875.
[36]
Bebrevska L, Foubert K, Hermans N, et al. In vivo antioxidative activity of a quantified Pueraria lobata root extract[J].J Ethnopharmacol,2010,127(1):112.
[37]
Terao J. Dietary flavonoids as antioxidants [J].Forum Nutr,2009,61:87.
[38]
Jakhar R, Paul S, Park Y R, et al. 3,5,7,3\',4\'-Pentamethoxyflavone,a quercetin derivative protects DNA from oxidative challenges: potential mechanism of action[J].J Photochem Photobiol B,2014,131:96.
[39]
Jiménez-Estrada M, Velázquez-Contreras C, Garibay-Escobar A, et al. In vitro antioxidant and antiproliferative activities of plants of the ethnopharmacopeia from northwest of Mexico[J].BMC Complement Altern Med,2013,13:12.
[40]
李富华,刘冬,明建.苦荞麸皮黄酮抗氧化及抗肿瘤活性研究[J].食品科学,2014(7):1.
[41]
Wensveen F M, Alves N L, Derks I A, et al. Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1[J].Apoptosis,2011,16(7):708.
[42]
Dichtel-Danjoy M L, Ma D, Dourlen P, et al. Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation[J].Cell Death Differ,2013,20(1):108.
[43]
Kim P Y, Rahmanto A S, Tan O, et al.TRIM16 overexpression induces apoptosis through activation of caspase-2 in cancer cells[J].Apoptosis,2013,18(5): 639.
[44]
Ooi H K, Ma L. Modeling heterogeneous responsiveness of intrinsic apoptosis pathway[J].BMC Syst Biol, 2013,7:65.
[45]
Wong R S. Apoptosis in cancer:from pathogenesis to treatment[J].J Exp Clin Cancer Res,2011,30:87.
Kim G T, Lee S H, Kim J I, et al. Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner[J].Int J Mol Med,2014,33(4):863.
[48]
Zhang X, Bi L, Ye Y, et al. Formononetin induces apoptosis in PC-3 prostate cancer cells through enhancing the Bax/Bcl-2 ratios and regulating the p38/Akt pathway[J].Nutr Cancer,2014,66(4):656.
[49]
Zhang H, Li X, Zhang Y, et al. Luteolin induces apoptosis by activating Fas signaling pathway at the receptor level in laryngeal squamous cell line Hep-2 cells[J].Eur Arch Otorhinolaryngol,2014,271(6):1653.
[50]
Hui C, Yujie F, Lijia Y, et al. MicroRNA-34a and microRNA-21 play roles in the chemopreventive effects of 3,6-dihydroxyflavone on 1-methyl-1-nitrosourea-induced breast carcinogenesis[J]. Breast Cancer Res,2012,14(3):R80.
[51]
Zhang D, Zhuang Y, Pan J, et al. Investigation of effects and mechanisms of total flavonoids of astragalus and calycosin on human erythroleukemia cells[J].Oxid Med Cell Longev,2012,2012:209843.
Lin C C, Yu C S, Yang J S, et al. Chrysin,a natural and biologically active flavonoid, influences a murine leukemia model in vivo through enhancing populations of T-and B-cells,and promoting macrophage phagocytosis and NK cell cytotoxicity[J]. In Vivo,2012,26(4):665.
[55]
Shi M D, Liao Y C, Shih Y W, et al. Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells[J].Phytomedicine,2013,20(8/9):743.
[56]
Baek S H, Kim S M, Nam D, et al. Antimetastatic effect of nobiletin through the down-regulation of CXC chemokine receptor type 4 and matrix metallopeptidase-9[J].Pharm Biol,2012,50(10):1210.
[57]
Lee Y C, Cheng T H, Lee J S, et al. Nobiletin, a citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cells[J].Mol Cell Biochem,2011,347(1/2):103.
[58]
Adjakly M, Ngollo M, Boiteux J P, et al. Genistein and daidzein: different molecular effects on prostate cancer[J].Anticancer Res,2013,33(1):39.
[59]
Choi E J, Kim G H. Antiproliferative activity of daidzein and genistein may be related to ERα/c-erbB-2 expression in human breast cancer cells[J].Mol Med Rep,2013,7(3):781.
Zhang X, Bi L, Ye Y, et al. Formononetin induces apoptosis in PC-3 prostate cancer cells through enhancing the Bax/Bcl-2 ratios and regulating the p38/Akt pathway[J].Nutr Cancer,2014,66(4):656.
[62]
Huang W J, Bi L Y, Li Z Z, et al. Formononetin induces the mitochondrial apoptosis pathway in prostate cancer cells via downregulation of the IGF-1/IGF-1R signaling pathway[J].Pharm Biol,2014,52(4):466.
[63]
Chen J, Zeng J, Xin M, et al. Formononetin induces cell cycle arrest of human breast cancer cells via IGF1/PI3K/Akt pathways in vitro and in vivo[J].Horm Metab Res,2011,43(10):681.
[64]
Auyeung K K, Ko J K. Novel herbal flavonoids promote apoptosis but differentially induce cell cycle arrest in human colon cancer cell[J]. Invest New Drugs, 2010,28(1):1.
[65]
Cufí S, Bonavia R, Vazquez-Martin A, et al. Silibinin suppresses EMT-driven erlotinib resistance by reversing the high miR-21/low miR-200c signature in vivo[J].Sci Rep,2013,3:2459.
[66]
Nasiri M, Zarghami N, Koshki K N, et al. Curcumin and silibinin inhibit telomerase expression in T47D human breast cancer cells[J].Asian Pac J Cancer Prev,2013,14(6):3449.
[67]
Sadava D, Kane S E. Silibinin reverses drug resistance in human small-cell lung carcinoma cells[J].Cancer Lett,2013,339(1):102.
[68]
Delgado L, Fernandes I, González-Manzano S, et al. Anti-proliferative effects of quercetin and catechin metabolites[J]. Food Funct, 2014,5(4):797.
[69]
Wang F, Chang Z, Fan Q, et al.Epigallocatechin-3-gallate inhibits the proliferation and migration of human ovarian carcinoma cells by modulating p38 kinase and matrix metalloproteinase-2[J]. Mol Med Rep,2014,9(3):1085.
[70]
Haratifar S, Meckling K A, Corredig M. Antiproliferative activity of tea catechins associated with casein micelles, using HT29 colon cancer cells[J].J Dairy Sci,2014,97(2):672.
[71]
He L, Zhang E, Shi J, et al.(-)-Epigallocatechin-3-gallate inhibits human papillomavirus (HPV)-16 oncoprotein-induced angiogenesis in non-small cell lung cancer cells by targeting HIF-1α[J].Cancer Chemother Pharmacol,2013,71(3):713.
[72]
You O H, Kim S H, Kim B, et al. Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells[J].Bioorg Med Chem Lett,2013,23(9):2692.
[73]
Jeong E J, Hwang L, Lee M, et al. Neuroprotective biflavonoids of Chamaecyparis obtusa leaves against glutamate-induced oxidative stress in HT22 hippocampal cells[J].Food Chem Toxicol,2014,64:397.
[74]
Ou Y C, Li J R, Kuan Y H, et al. Luteolin sensitizes human 786-O renal cell carcinoma cells to TRAIL-induced apoptosis[J]. Life Sci,2014,100(2):110.
Liu C, Li X W, Cui L M, et al. Inhibition of tumor angiogenesis by TTF1 from extract of herbal medicine[J].World J Gastroenterol,2011,17(44): 4875.
[77]
Pratheeshkumar P, Son Y O, Budhraja A, et al. Luteolin inhibits human prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis[J].PLoS ONE,2012,7(12):e52279.
[78]
刘晓,温瑞兴.中药抗肿瘤作用的研究进展[J].现代生物医学进展,2011,11(24):4978.
[79]
Liu Y, Xie S, Wang Y, et al. Liquiritigenin inhibits tumor growth and vascularization in a mouse model of HeLa cells[J]. Molecules,2012,17(6):7206.
Bertorelle R, Rampazzo E, Pucciarelli S, et al. Telomeres, telomerase and colorectal cancer[J].World J Gastroenterol,2014,20(8):1940.
[90]
傅青岭,刘厚奇.端粒酶与癌症靶向治疗[J].生命科学,2010,22(12):1254.
[91]
Holysz H, Lipinska N, Paszel-Jaworska A, et al. Telomerase as a useful target in cancer fighting—the breast cancer case[J].Tumor Biol,2013,34(3):1371.
[92]
Khaw A K, Yong J W, Kalthur G, et al. Genistein induces growth arrest and suppresses telomerase activity in brain tumor cells[J].Genes Chromosomes Cancer,2012,51(10):961.
[93]
Brechbuhl H M, Kachadourian R, Min E, et al. Chrysin enhances doxorubicin-induced cytotoxicity in human lung epithelial cancer cell lines: the role of glutathione[J].Toxicol Appl Pharmacol,2012,258(1): 1.
[94]
Vjetrovic J, Shankaranarayanan P, Mendoza-Parra M A, et al. Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis[J].Aging Cell,2014,13(3):487.
Ombra M N, Di Santi A, Abbondanza C, et al. Retinoic acid impairs estrogen signaling in breast cancer cells by interfering with activation of LSD1 via PKA[J].Biochim Biophys Acta,2013,1829(5):480.
[97]
Cai X, Fang Z, Dou J, et al. Bioavailability of quercetin: problems and promises[J].Curr Med Chem,2013,20(20):2572.
[98]
Liao Y, Shen W, Kong G, et al. Apigenin induces the apoptosis and regulates MAPK signaling pathways in mouse macrophage ANA-1 cells[J].PLoS ONE,2014,9(3):e92007.
[99]
Lee Y, Sung B, Kang Y J, et al. Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells[J].Int J Oncol,2014,44(5):1599.
[100]
Sharma H, Kanwal R, Bhaskaran N, et al. Plant flavone apigenin binds to nucleic acid bases and reduces oxidative DNA damage in prostate epithelial cells[J].PLoS ONE,2014,9(3):e91588.
[101]
Zhang Y, Song L, Cai L, et al. Effects of baicalein on apoptosis,cell cycle arrest,migration and invasion of osteosarcoma cells[J]. Food Chem Toxicol,2013,53:325.
[102]
Boots A W, Haenen G R, Bast A. Health effects of quercetin: from antioxidant to nutraceutical[J].Eur J Pharmacol,2008,585(2/3):325.
[103]
Cao X ,Liu M, Tuo J, et al. The effects of quercetin in cultured human PRE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice[J].Exp Eye Res,2010,91(1):15.
[104]
Kim S H, Choi K C. Anti-cancer effect and underlying mechanism(s) of kaempferol, a phytoestrogen, on the regulation of apoptosis in diverse cancer cell models[J].Toxicol Res,2013,29(4):229.
[105]
Lee H S, Cho H J, Yu R, et al. Mechanisms underlying apoptosis-inducing effects of kaempferol in HT-29 human colon cancer cells[J].Int J Mol Sci,2014,15(2):2722.
[106]
Xie F, Su M, Qiu W. et al. Kaempferol promotes apoptosis in human bladder cancer cells by inducing the tumor suppressor,PTEN[J].Int J Mol Sci,2013,14(11):21215.
[107]
Chen H J, Lin C M, Lee C Y, et al. Kaempferol suppresses cell metastasis via inhibition of the ERK-p38-JNK and AP-1 signaling pathways in U-2 OS human osteosarcoma cells[J].Oncol Rep,2013,30(2):925.
[108]
Li C, Yang X, Chen C, et al. Isorhamnetin suppresses colon cancer cell growth through the PI3K-Akt-mTOR pathway[J].Mol Med Rep,2014,9(3):935.
[109]
Ramachandran L, Manu K A, Shanmugam M K, et al. Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer[J].J Biol Chem,2012,287(45):38028.
[110]
Boubaker J, Bhouri W, Ben Sghaier M, et al. Ethyl acetate extract and its major constituent, isorhamnetin 3-O-rutinoside, from Nitraria retusa leaves, promote apoptosis of human myelogenous erythroleukaemia cells[J].Cell Prolif,2011,44(5):453.
[111]
Boubaker J, Ben Sghaier M, Skandrani I, et al. Isorhamnetin 3-O-robinobioside from Nitraria retusa leaves enhance antioxidant and antigenotoxic activity in human chronic myelogenous leukemia cell line K562[J].BMC Complement Altern Med,2012,12:135.
[112]
Gawlik-Dziki U, wieca M, Sutkowski M, et al. Antioxidant and anticancer activities of Chenopodium quinoa leaves extracts- in vitro study[J].Food Chem Toxicol,2013,57:154.
[113]
Kim M E, Ha T K, Yoon J H, et al. Myricetin induces cell death of human colon cancer cells via BAX/BCL2-dependent pathway[J].Anticancer Res,2014,34(2):701.
[114]
Zhang X H, Chen S Y, Tang L, et al. Myricetin induces apoptosis in HepG2 cells through Akt/p70S6K/bad signaling and mitochondrial apoptotic pathway[J].Anticancer Agents Med Chem,2013,13(10):1575.
[115]
Siegelin M D, Gaiser T, Habel A, et al. Myricetin sensitizes malignant glioma cells to TRAIL-mediated apoptosis by down-regulation of the short isoform of FLIP and bcl-2[J].Cancer Lett,2009,283(2):230.
[116]
Shih Y W, Wu P F, Lee Y C, et al. Myricetin suppresses invasion and migration of human lung adenocarcinoma A549 cells: possible mediation by blocking the ERK signaling pathway[J].J Agric Food Chem,2009,57(9):3490.
[117]
Li W, Liu M, Xu Y F, et al. Combination of quercetin and hyperoside has anticancer effects on renal cancer cells through inhibition of oncogenic microRNA-27a[J].Oncol Rep,2014,31(1):117.
[118]
Jakobs D, Hage-Hülsmann A, Prenner L, et al. Downregulation of β1-adrenergic receptors in rat C6 glioblastoma cells by hyperforin and hyperoside from St John\'s wort[J].J Pharm Pharmacol,2013,65(6):907.
[119]
Li F R, Yu F X, Yao S T, et al. Hyperin extracted from Manchurian rhododendron leaf induces apoptosis in human endometrial cancer cells through a mitochondrial pathway[J].Asian Pac J Cancer Prev, 2012,13(8):3653.
[120]
Wang Y, Xie S, Liu C, et al. Inhibitory effect of liquiritigenin on migration via 6ownregulation proMMP-2 and PI3K/Akt signaling pathway in human lung adenocarcinoma A549 cells[J].Nutr Cancer,2012,64(4):627.
[121]
Saiprasad G, Chitra P, Manikandan R, et al. Hesperidin alleviates oxidative stress and downregulates the expressions of proliferative and inflammatory markers in azoxymethane-induced experimental colon carcinogenesis in mice[J]. Inflamm Res,2013,62(4):425.
[122]
Nandakumar N, Balasubramanian M P. Hesperidin a citrus bioflavonoid modulates hepatic biotransformation enzymes and enhances intrinsic antioxidants in experimental breast cancer rats challenged with 7, 12-dimethylbenz (a) anthracene[J].J Exp Ther Oncol,2012,9(4):321.
[123]
Nandakumar N, Balasubramanian M P. Hesperidin protects renal and hepatic tissues against free radical-mediated oxidative stress during DMBA-induced experimental breast cancer[J].J Environ Pathol Toxicol Oncol, 2011,30(4):283.
[124]
Ghorbani A, Nazari M, Jeddi-Tehrani M, et al. The citrus flavonoid hesperidin induces p53 and inhibits NF-κB activation in order to trigger apoptosis in NALM-6 cells: involvement of PPARγ-dependent mechanism[J].Eur J Nutr,2012,51(1):39.
