全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

疾病状态下的中药药代动力学研究进展

Keywords: 药代动力学,病理状态,药物代谢酶,转运蛋白

Full-Text   Cite this paper   Add to My Lib

Abstract:

近年来,越来越多的研究表明中药的药代动力学特征能够被疾病状态所影响,生理及病理的变化在一定程度上会影响机体内的药物代谢酶、转运蛋白、细胞膜的通透性以及微生物菌群的改变,从而改变中药在机体内的吸收、分布、代谢和排泄过程,进而引起中药的药代动力学参数的改变.鉴于中药主要是用于病理状态的机体内,故研究机体病理状态下的药动学参数较正常状态下更有意义.该文拟就中药在糖尿病、脑缺血、肝损伤、炎性疾病、神经系统疾病以及发热等疾病状态下的药代动力学的研究作一综述,以期为临床针对不同的机体状态,设计合理安全的用药剂量提供一定的参考.

References

[1]  Cressman A M, Petrovic V, Piquette M M. Inflammation-mediated changes in drug transporter expression/activity: implications for therapeutic drug response[J]. Expert Rev Clin Pharmacol, 2012, 5(1): 69.
[2]  Gong H L, Tang W F, Yu Q, et al. Effect of severe acute pancreatitis onpharmacokinetics of Da-Cheng-Qi Decoction components[J]. World J Gastroenterol, 2009, 15(47): 5992.
[3]  Zhao X L, Xiang J, Wan, M H, et al. Effect of acute pancreatitis on the pharmacokinetics of Chinese herbal ointment Liu-He-Dan in anaesthetized rats[J]. J Ethnopharmacol, 2013, 145(1): 94.
[4]  Ma B L, Yao M K, Zhong J, et al. Increased systemic exposure to Rhizoma Coptidis alkaloids in lipopolysaccharide-pretreated rats due to enhanced intestinal absorption[J]. Drug Metab Dispos, 2012, 40 (2): 381.
[5]  Ma B L, Ma Y M, Gao C L, et al. Lipopolysaccharide increased the acute toxicity of the Rhizoma Coptidis extract in mice by increasing the systemic exposure to Rhizoma Coptidis alkaloids[J]. J Ethnopharmacol, 2011, 138(1): 169.
[6]  Gong Z P, Chen Y, Zhang R, et al. Pharmacokinetic comparison of berberine in rat plasma after oral administration of berberine hydrochloride in normal and post inflammation irritable bowel syndrome rats[J]. Int J Mol Sci, 2014, 15(1): 456.
[7]  Zhang Z Q, Liu W, Zhuang L, et al. Comparative pharmacokinetics of baicalin, wogonoside, baicalein and wogonin in plasma after oral administration of pure baicalin, radix scutellariae and scutellariae-paeoniae couple extracts in normal and ulcerative colitis rats[J]. Iran J Pharm Res, 2013, 12 (3): 399.
[8]  Lv C X, Li Q, Zhang Y M, et al. A UFLC-MS/MS method with a switching ionization mode for simultaneous quantitation of polygalaxanthone Ⅲ, four ginsenosides and tumulosic acid in rat plasma: application to a comparative pharmacokinetic study in normal and Alzheimer\'s disease rats[J]. J Mass Spectrom, 2013, 48:904.
[9]  Xie W, Qiu X, Huang X, et al. Comparison between the pharmacokinetics of meranzin hydrate in a rat model of chronic depression and in controls following the oral administration of Chaihu-Shugan-San[J]. Exp Ther Med, 2013, 6 (4): 913.
[10]  He B S, Li Q, Jia Y, et al. A UFLC-MS/MS method for simultaneous quantitation of spinosin, mangiferin and ferulic acid in rat plasma: application to a comparative pharmacokinetic study in normal and insomnic rats[J]. J Mass Spectrom, 2012, 47(10): 1333.
[11]  Wang Y H, Hong Y L, Feng Y, et al. Comparative pharmacokinetics of senkyunolide Ⅰ in a rat model of migraine versus normal controls[J]. Eur J Drug Metab Pharmacokinet, 2012, 37: 91.
[12]  Wang Z, Hall S D, Maya J F, et al. Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans[J]. Br J Clin Pharmacol, 2003, 55(1): 77.
[13]  Pass G J, Becker W, Kluge R, et al. Effect of hyperinsulinemia and type 2 diabetes-like hyperglycemia on expression of hepatic cytochrome p450 and glutathione s-transferase isoforms in a New Zealand obese-derived mouse backcross population[J]. J Pharmacol ExpTher, 2002, 302(2): 442.
[14]  Lam J L, Jiang Y, Zhang T, et al. Expression and functional analysis of hepatic cytochromes P450, nuclear receptors, and membrane transporters in 10- and 25-week-old db/db mice[J]. Drug Metab Dispos, 2010, 38(12): 2252.
[15]  Kim S K, Novak R F. The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression[J]. Pharmacol Ther, 2007, 113(1): 88.
[16]  Xie H, Sun S Q, Cheng X F, et al. Dysregulations of intestinal and colonic UDP-glucuronosyferases in rats with type 2 diabetes[J]. Drug Metab Pharmacokinet, 2013, 28(5): 427.
[17]  Goi G, Bairati C, Segalini G, et al. Alterations in the activity of several glycohydrolases in red blood cell membrane from type 2 diabetes mellitus patients[J]. Metabolism, 1999, 48(7): 817.
[18]  Oh S J, Choi J M, Yun K U, et al. Hepatic expression of cytochrome P450 in type 2 diabetic Goto-Kakizaki rats[J]. Chem Biol Interact, 2012, 195(3): 173.
[19]  Wu K C, Pan H J, Yin H S, et al. Change in P-glycoprotein and caveolin protein expression in brain striatum capillaries in New Zealand obese mice with type 2 diabetes[J]. Life Sci, 2009, 85(23/26): 775.
[20]  Tong X Z, Zhu H, Shi Y, et al. An LC/MS/MS method for simultaneous quantitation of two homoisoflavones: protosappanin B and brazilin with hypoglycemic activity in rat plasma and its application to a comparative pharmacokinetic study in normal and streptozotocin-treated rats[J]. J Ethnopharmacol, 2013, 148 (2): 682.
[21]  Lee J H, Lee A, Lee Y J, et al. Comparative pharmacokinetic study of paclitaxel and docetaxel in streptozotocin-induced diabetic rats[J]. Biopharm Drug Dispos, 2012, 33(8): 474.
[22]  Deng Y X, Shi Q Z, Chen B, et al. Comparative pharmacokinetics of baicalin in normal and the type 2 diabetic rats after oral administration of the Radix Scutellariae extract[J]. Fitoterapia, 2012, 83(8): 1435.
[23]  Liu Q F, Shi X J, Li Z D, et al. Pharmacokinetic comparisons of berberine and palmatine in normal and metabolic syndrome rats[J]. J Ethnopharmacol, 2014, 151(1): 287.
[24]  Feng Y, Liu Z, Peng Y, et al.Validated LC-MS method for simultaneous quantitation of catalpol and harpagide in rat plasma: application to a comparative pharmacokinetic study in normal and diabetic rats after oral administration of Zeng-Ye-Decoction[J]. Biomed Chromatogr, 2013, 27(11): 150.
[25]  Meairs S, Wahlgren N, Dirnagl U, et al. Stroke research priorities for the next decade-a representative view of the European scientific community[J]. Cerebrovasc Dis, 2006, 22(2-3): 75.
[26]  胡霞敏,曾繁典. β-七叶皂苷钠在脑缺血再灌注大鼠体内药代动力学的研究[J]. 中国临床药理学与治疗学, 2005, 10(7): 828.
[27]  Zeng M F, Pan L M, Zhu H X, et al. Comparative pharmacokinetics of baicalin in plasma after oral administration of Huang-Lian-Jie-Du-Tang or pure baicalin in MCAO and sham-operated rats[J]. Fitoterapia, 2010, 81(6): 490.
[28]  Xu P, Li Y, Du S Y, et al. Comparative pharmacokinetics of borneol in cerebral ischemia-reperfusion and sham-operated rats[J]. J Zhejiang Univ Sci B, 2014, 15(1): 84.
[29]  Zhu H X, Qian Z L, He F, et al. Novel pharmacokinetic studies of the Chinese formula Huang-Lian-Jie-Du-Tang in MCAO rats[J]. Phytomedicine, 2013, 20(10): 767.
[30]  Pan L M, Qiu B H, Li H, et al. In vivo studies on the pharmacokinetics of berberine on middle cerebral artery occlusion rat and sham-operated rat[J]. Afri J Pharma and Pharmacol, 2011, 5(16): 1824.
[31]  Adawi D, Kasravi F B, Molin G. Manipulation of nitric oxide in an animal model of acute liver injury. The impact on liver and intestinal function[J]. Libyan J Med, 2007, 2(2): 73.
[32]  Li Y T, Wang L, Chen Y, et al. Effects of gut microflora on hepatic damage after acute liver injury in rats[J]. J Trauma, 2010, 68(1): 76.
[33]  李娜,吴磊,苏云明,等. 急性CCl4肝损伤对大鼠芍药苷药代动力学的影响[J]. 中国药科大学学报, 2009, 40 (1): 77.
[34]  刘恩荔,谢敏,王玉峰,等. 白芍总苷在急性CCl4肝损伤大鼠与正常大鼠体内的药代动力学比较研究[J]. 中国药学杂志, 2012, 47(7): 534.
[35]  张玲非,刘敏彦,潘会敏,等.白芍总苷在免疫性肝损伤大鼠体内的药代动力学研究[J]. 中国药理学通报, 2011, 27(10): 1462.
[36]  Jiang F J, Zhao Y L, Wang J B, et al. Comparative pharmacokinetic study of paeoniflorin and albiflorin after oral administration of Radix Paeoniae Rubra in normal rats and the acute cholestasis hepatitis rats[J]. Fitoterapia, 2012, 83(2): 415.
[37]  Fang F, Wang J B, Zhao Y L, et al. A comparative study on the tissue distributions of rhubarb anthraquinones in normal and CCl4-injured rats orally administered rhubarb extract[J]. J Ethnopharmacol, 2011,137(3): 1492.
[38]  孙虹,赵玉男,邢东明,等. 感冒一小时胶囊中黄芩苷在正常与发热大鼠体内动力学特点的比较[J].中药药理与临床杂志, 2003, 19(4): 34.
[39]  Gao R, Lin Y, Liang G, et al. Comparative pharmacokinetic study of chlorogenic acid after oral administration of Lonicerae Japonicae Flos and Shuang-Huang-Lian in normal and febrile rats[J]. Phytother Res, 2014, 28(1): 144.
[40]  Wang X F, Zhao X, Gu L Q, et al. Simultaneous determination of five free and total flavonoids in rat plasma by ultra HPLC-MS/MS and its application to a comparative pharmacokinetic study in normal and hyperlipidemic rats[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2014(953/954): 1.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133