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天然产物薯蓣皂苷的研究进展

Keywords: 薯蓣皂苷,天然产物,药理活性,含量测定

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Abstract:

薯蓣皂苷是一种典型的天然皂苷类化合物,广泛存在于薯蓣科、百合科、石竹科和蔷薇科等药用植物中,尤其是在薯蓣科植物中含量丰富,如穿龙薯蓣、盾叶薯蓣和黄山药等。中医学认为,薯蓣皂苷具有祛痰、舒筋活血、消食利水等作用。近年来,随着科学技术的不断发展,对薯蓣皂苷的研究也日新月异,一些新的提取分离技术、新的生物活性及相关应用不断被发现。现代药理学研究证实薯蓣皂苷还具有脱敏、抗炎、降脂、抗肿瘤、保肝、抗病毒等作用。薯蓣皂苷口服后经肠道菌群代谢产生的薯蓣皂苷元是发挥作用的真正有效成分,而且它还是合成甾体激素类药物的重要原料,因此,对薯蓣皂苷的研究极具价值,并且有广阔的应用前景。该文从提取技术、分离制备、化学合成、药物代谢、含量测定和药理作用等几方面对薯蓣皂苷的研究进展作一简要的综述。

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