Nickavar B, Abolhasani L. Bioactivity-guided separation of an α-amylase inhibitor flavonoid from Salvia virgata[J]. Iran J Pharm Res, 2013,12(1):57.
[2]
De Sousa LR, Ramalho S D, Burger M C, et al. Isolation of arginase inhibitors from the bioactivity-guided fractionation of Byrsonima coccolobifolia leaves and stems[J]. J Nat Prod, 2014,77(2):392.
[3]
Lou Y, Zhang H, He H, et al. Isolation and identification of phase Ⅰ metabolites of curcumol in rats[J]. Drug Metab Dispos, 2010,38(11):2014.
[4]
Xu H, Li Y, Che X, et al. Metabolism of salvianolic acid A and antioxidant activities of its methylated metabolites[J]. Drug Metab Dispos, 2014,42(2):274.
[5]
Kong W J, Wang J B, Zang Q C, et al. A novel "target constituent knock-out" strategy coupled with TLC, UPLC-ELSD and microcalorimetry for preliminary screening of antibacterial constituents in calculus bovis[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2011,879(30):3565.
Wang H, Sun H, Zhang A, et al. Rapid identification and comparative analysis of the chemical constituents and metabolites of Phellodendri amurensis cortex and Zhibai dihuang pill by ultra-performance liquid chromatography with quadrupole TOF-MS[J]. J Sep Sci, 2013,36(24):3874.
[9]
Wang X, Sun W, Sun H, et al. Analysis of the constituents in the rat plasma after oral administration of Yin Chen Hao Tang by UPLC/Q-TOF-MS/MS[J]. J Pharm Biomed Anal, 2008,46(3):477.
Li S, Chou G, Hseu Y, et al. Isolation of anticancer constituents from flos genkwa (Daphne genkwa Sieb.et Zucc.) through bioassay-guided procedures[J]. Chem Cent J, 2013,7(1):159.
[16]
Meng Q X, Roubin R H, Hanrahan J R. Ethnopharmacological and bioactivity guided investigation of five TCM anticancer herbs[J]. J Ethnopharmacol, 2013,148(1):229.
Gong P, Cui N, Wu L, et al. Chemicalome and metabolome matching approach to elucidating biological metabolic networks of complex mixtures[J]. Anal Chem, 2012,84(6):2995.
[27]
Yang M, Cheng C, Yang J, et al. Metabolite profiling and characterization for medicinal herbal remedies[J]. Curr Drug Metab, 2012,13(5):535.
[28]
Liu Z, Liu M, Qi Y, et al. Plasma pharmacochemistry combined with microdialysis to screen potential bioactive components and their metabolites in Anemarrhena asphodeloides saponin extract using ultrahigh-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry[J]. J Sep Sci, 2013,36(9/10):1659.
[29]
Hu Y, Jiang P, Wang S, et al. Plasma pharmacochemistry based approach to screening potential bioactive components in Huang-Lian-Jie-Du-Tang using high performance liquid chromatography coupled with mass spectrometric detection[J].J Ethnopharmacol, 2012,141(2):728.
[30]
Zeng W, Han H, Tao Y, et al. Identification of bio-active metabolites of gentiopicroside by UPLC/Q-TOF MS and NMR[J]. Biomed Chromatogr, 2013,27(9):1129.
Wang X, Sun W, Sun H, et al. Analysis of the constituents in the rat plasma after oral administration of Yin Chen Hao Tang by UPLC/Q-TOF-MS/MS[J]. J Pharm Biomed Anal, 2008,46(3):477.
[33]
Wang X, Sun H, Zhang A, et al. Pharmacokinetics screening for multi-components absorbed in the rat plasma after oral administration traditional Chinese medicine formula Yin-Chen-Hao-Tang by ultra performance liquid chromatography-electrospray ionization/quadrupole-time-of-flight mass spectrometry combined with pattern recognition methods[J].Analyst, 2011, 136(23):5068.
[34]
Lv H, Sun H, Sun W, et al. Pharmacokinetic studies of a Chinese triple herbal drug formula[J]. Phytomedicine, 2008,15(11):993.
Cao H, Chen X, Sun H, et al. Pharmacokinetics-based elucidation on disparity in clinical effectiveness between varieties of Zhi Zhu Wan, a traditional Chinese medical formula[J]. J Ethnopharmacol, 2010,128(3):606.
Yan G L, Zhang A H, Sun H, et al. An effective method for determining the ingredients of Shuanghuanglian formula in blood samples using high-resolution LC-MS coupled with background subtraction and a multiple data processing approach[J]. J Sep Sci, 2013,36(19):3191.
[42]
Wang Ping, Yin Quanwei, Zhang Aihua, et al. Preliminary identification of the absorbed bioactive components and metabolites in rat plasma after oral administration of Shaoyao-Gancao decoction by ultra-performance liquid chromatography with electrospray ionization tandem mass spectrometry[J]. Pharmacogn Mag, 2014,10(40):497.
Wang X, Zhang A, Sun H. Future perspectives of Chinese medical formulae: chinmedomics as an effector[J]. OMICS,2012,16(7/8):414.
[47]
Wang X, Zhang A, Han Y, et al. Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease[J]. Mol Cell Proteomics, 2012,11(8):370.
[48]
Wang X, Zhang A, Sun H. Power of metabolomics in diagnosis and biomarker discovery of hepatocellular carcinoma[J]. Hepatology, 2013,57(5):2072.
[49]
Wang X, Yang B, Sun H, et al. Pattern recognition approaches and computational systems tools for ultra performance liquid chromatography-mass spectrometry-based comprehensive metabolomic profiling and pathways analysis of biological data sets[J]. Anal Chem, 2012,84(1):428.
[50]
Wang X, Wang H, Zhang A, et al. Metabolomics study on the toxicity of aconite root and its processed products using ultraperformance liquid-chromatography/ electrospray-ionization synapt high-definition mass spectrometry coupled with pattern recognition approach and ingenuity pathways analysis[J]. J Proteome Res, 2012,11(2):1284.
[51]
Wang X, Yang B, Zhang A, et al. Potential drug targets on insomnia and intervention effects of Jujuboside A through metabolic pathway analysis as revealed by UPLC/ESI-SYNAPT-HDMS coupled with pattern recognition approach[J]. J Proteomics, 2012,75(4):1411.
[52]
Zhang A, Sun H, Han Y, et al. Urinary metabolic biomarker and pathway study of hepatitis B virus infected patients based on UPLC-MS system[J].PLoS One, 2013,8(5):e64381.
[53]
Zhang A, Sun H, Han Y, et al. Exploratory urinary metabolic biomarkers and pathways using UPLC-Q-TOF-HDMS coupled with pattern recognition approach[J]. Analyst, 2012,137(18):4200.