Meagher L P,Beecher G R.Assessment of data on the lignan content of foods[J].J Food Compos Anal,2000,13(6):935.
[2]
Niemeyer H B,Honig D M,Kulling S E,et al.Studies on the metabolism of the plant lignans secoisolariciresinol and matairesinol.J Agric Food Chem,2003,51(21):6317.
[3]
Bowey E,Adlercreutz H,Rowland I.Metabolism of isoflavones and lignans by the gut microflora:a study in germ-free and human flora associated rats[ J ].Food Chem Toxicol,2003,41 (5):631.
Wang L Q,Meselhy M R,Li Y,et al.Human intestinal bacteria capable of transforming seonisolariciresinol diglucoside to mammalian lignans,enterodiol and enterolactone[ J ].Chem Pharm Bull,2000,48(1):1606.
[6]
Sch(o)tner M,Spiteller G.Lignans interfering with 5 alpha-dihydrotestosterone binding to human sex hormone-binding globulin[J].J Nat Prod,1998,61(1):119.
[7]
Evans B A,Griffiths K,Morton M S.Inhibition of 5 alpha-reductase in genital skin fibroblasts and prostate tissue by dietary lignans and isoflavonoids[J].J Endocrinol,1995,147(2):295.
[8]
Lemay A,Dodin S,Kadri N,et al.Flaxseed dietary supplement versus hormone replacement therapy in hypercholesterolemic menopausal women[J].Obstet Gynecol,2002,100(3):495.
[9]
Lucas E A,Wild R D,Hammond L J,et al.Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women[ J ].J Clin Endocr Metab,2002,87 (4):1527.
[10]
Vanharanta M,Voutilainen S,Rissanen T H,et al.Risk of cardiovascular disease-related and all-cause death according to serum concentrations of enterolactone:Kuopio Ischaemic Heart Disease Risk Factor Study[ J ].Arch Intern Med,2003,163 (9):1099.
[11]
Westcott N D,Muir A D.Flax seed lignan in disease prevention and health promotion[J].Phytochemistry Rev,2003,2(3):401.
[12]
Demark-Wahnefried W,Price D T,Polascik T J,et al.Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery:exploring the effects on hormonal levels,prostate-specific antigen,and histopathologic features[ J ].Urology,2001,58 (1):47.
[13]
Leake A,Chrisholm G D,Habib F K.The effect of zinc on the 5 alpha-reduction of testosterone by the hyperplastic human prostate gland[J].J Steroid Biochem,1984,20(2):651.
[14]
Lagiou P,Wuu J,Trichopoulou A,et al.Diet and benign prostatic hyperplasia:a study in Greece[J].Urology,1999,54(2):284.
[15]
Kitts D D,Yuan Y V,Wijewickreme A N,et al.Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone[J].Mol Cell Biochem,1999,202(1-2):91.
[16]
Prasad K.Antioxidant activity of secoisolariciresinol diglucosidederived metabolites,secoisolariciresinol,enterodiol,and enterolactone[J].Int J Angiol,2000,9(4):220.
[17]
Niemeyer H B,Metzler M.Differences in the antioxidant activity of plant and mammalian lignans[ J ].J Food Eng,2003,56 (2):255.
[18]
Pool-Zobel B L,Adlercreutz H,Glei M,et al.Isoflavonoids and lignans have different potentials to modulate oxidative genetic damage in human colon cells[J].Carcinogenesis,2000,21 (6):1247.
[19]
Wang C,Kurzer M S.Phytoestrogen concentration determines effects on DNA synthesis in human breast cancer cells[ J ].Nutr Cancer,1997,28(3):236.
[20]
Saarinen N M,Penttinen P E,Smeds A I,et al.Structural determinants of plant lignans for growth of mammary tumors and hormonal responses in vivo[ J].J Chromatogr B,2002,777(1-2):311.
[21]
Dabrosin C,Chen J,Wang L,et al.Flaxseed inhibits metastasis and decreases extracellular vascular endothelial growth factor in human breast cancer xenografts[J].Cancer Lett,2002,185(1):31.
[22]
Dai Q,Franke A A,Yu H,et al.Urinary Phytoestrogen excretion and breast cancer risk:evaluating potential effect modifiers endogenous estrogens and anthropometrics[J].Cancer Epidem Biomar Prev,2003,12(6):497.
[23]
den Tonkelaar I,Keinan-Boker L,Veer P V,et al.Urinary phytoestrogens and postmenopausal breast cancer risk[ J ].Cancer Epidem Biomar and Prey,2001,10(3):223.
[24]
McCann S E,Moysich K B,Freudenheim J L,et al.The risk of breast cancer associated with dietary lignans differs by CYP17 genotype in women[J].J Nutr,2002,132(10):3036.
[25]
Bylund A,Zhang J X,Bergh A,et al.Rye bran and soy protein delay growth and increase apoptosis of human LNCaP prostate adenocarcinoma in nude mice[J].Prostate,2000,42(4):304.
[26]
Lin X,Gingrich J R,Bao W,et al.Effect of flaxseed supplementation on prostatic carcinomain transgenic mice[ J ].Urology,2002,60(5):919.
[27]
Bylund A,Saarinen N,Zhang J X,et al.Anticancer effects of a plant lignan 7-hydroxymatairesinol on a prostate cancer model in vivo[J].Exp Biolog Med,2005,230(3):217.
[28]
Bylund A,Lundin E,Zhang J X,et al.Randomised controlled short-term intervention pilot study on rye bran bread in prostate cancer[J].Eur J Cancer Prev,2003,12(5):407.
[29]
Kamal-Eldina A,Peerlkampa N,Johnsson P,et al.An oligomer from flaxseed composed of secoisolariciresinoldiglucoside and 3-hydroxy-3-methyl glutaric acid residues[ J ].Phytochem,2001,58(4):587.
[30]
Liggins J,Grimwood R,Bingham S A.Extraction and quantification of lignan phytoestrogens in food and human samples[J].Anal Biochem,2000,287(1):102.
[31]
Obermeyer W R,Musser S M,Betz J M,et al.Chemical studies of phytoestrogens and related compounds in dietary supplements:Flax and chaparral[J].Proc Soc Exp Biol Med,1995,208(1):6.
[32]
Murkovica M,Piironenb V,Lampib A M,et al.Changes in chemical composition of pumpkin seeds during the roasting process for production of pumpkin seed oil (Part 1:non-volatile compounds)[J].Food Chem,2004,84(3):359.
[33]
Adlercreutz H,Wang G J,Lapc K O,et al.Time-resolved fluoroimmunoassay for plasma enterolactone[ J ].Analy Biochem,1998,265(2):208.
[34]
Pennalvo J L,Haajanen K M,Botting N,et al.Quantification of lignans in food using isotope dilution gas chromatography/mass spectrometry[J].J Agric Food Chem,2005,53:9342.
[35]
Milder I E,Arts I C,Putte B,et al.Lignan contents of dutch plant foods:A database including lariciresinol,pinoresinol,secoisolariciresinol and matairesinol[ J].Br J Nutr,2005,93:393.
[36]
Mazur W,Uehara M,Whl K,et al.Phyto-oestrogen content of berries,and plasma concentrations and urinary excretion of enterolactone after a single strawberry-meal in human subjects[J].Br J Nutr,2000,83(4):381.
[37]
Borriello S P,Setchell K D,Axelson M,et al.Production and metabolism of lignans by the human fecal flora[J].J Appl Bacteriol,1985,58(1):37.
[38]
Heinonen S,Nurmi T,Liukkonen K,et al.In vitro metabolism of plant lignans:new precursors of mammalian lignans enterolactone and enterodiol[J].J Agric Food Chem,2001,49(7):3178.
[39]
Jacobs E,Kulling S E,Metzler M.Novel metabolites of the mammalian lignans enterolactone and enterodiol in human urine[J].J Steroid Biochem Mol Biol,1999,68(5):211.
[40]
Niemeyer H B,Honig D,Lange-B(o)hmer A,et al.Oxidative metabolites of the mammalian lignans enterodiol and enterolactone in rat bile and urine[ J ].J Agric Food Chem,2000,48 (7):2910.
[41]
Rickard S E,Thompson L U.Chronic exposure to secoisolariciresinol diglycoside alters lignan disposition in rats[ J ].J Nutr,1998,128(3):615.
[42]
Boccardo F,Lunardi G L,Petti A R,et al.Enterolactone in breast cyst fluid:correlation with EGF and breast cancer risk[J].Breast Cancer Res Treat,2003,79(1):17.
[43]
Mousavi Y,Adlercreutz H.Enterolactone and estradiol inhibit each other\'s proliferative effect on MCF-7 breast cancer cells in culture[J].J Steroid Biochem Mol Biol,1992,41(3-8):615.
[44]
Adlercreutz H,Bannwart C,Wahala K,et al.Inhibition of human aromatase by mammalian lignans and isoflavonoid phytoestrogens[J].J Steroid Biochem Mol Biol,1993,44(2):147.
[45]
Adlercreutz H,Mousavi Y,Clark J,et al.Dietary phytoestrogens and cancer:in vitro and in vivo studies[J].J Steroid Biochem Mol Biol,1992,41(3-8):331.
