Yao H,Zhou J,Li D,et al.FK506 enhances triptolide-induced down-regulation of cyclooxygenase-2,inducible nitric oxide synthase as well as their products PGE2 and NO in TNF-alpha-stimulated synovial fibroblasts from rheumatoid arthritic patients[J].Eur J Med Res,2005,10(3):110.
[5]
Wang B,Ma L,Tao X,et al.Triptolide,an active component of the Chinese herbal remedy Tripterygium wilfordii Hook F,inhibits production of nitric oxide by decreasing inducible nitric oxide synthase gene transcription[J].Arthritis Rheum,2004,50 (9):2995.
[6]
Kim Y H,Lee S H,Lee J Y,et al.Triptolide inhibits murine-inducible nitric oxide synthase expression by down-regulating lipopolysaccharide-induced activity of nuclear factor-kappa B and c-Jun NH(2)-terminal kinase[J].Eur J Pharmacol,2004,494(1):1.
Kusunoki N,Yamazaki R,Kitasato H,et al.Triptolide,an active compound identified in a traditional Chinese herb,induces apoptosis of rheumatoid synovial fibroblasts[J].BMC Pharmacol,2004,4(1):2.
Lin N,Sato T,Ito A.Triptolide,a novel diterpenoid triepoxide,from Tripterygium wilfordii Hook.f.suppresses the production and gene expression of matrix metalloproteinasas-1 and -3 and augments the expression of tissue inhibitors metalloproteinasas-1 and -2 in human synovial[J].Arthritis Rheum,2001,44(9):2193.
Vincenti M P.The matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) genes.Transcriptional and post-transcriptional regulation,signal transduction and cell-typespecific expression[J].Methods Mol Biol,2001,151:121.
[20]
Jue D M,Jeon K I,Jeong J Y.Nuclear factor kappa B (NF-κB) pathway as a therapeutic target in rheumatoid arthritis[J].J Korean Med Sci,1999,14:231.
[21]
Liu H,Liu Z H,Chen Z H,et al.Triptolide:a potent inhibitor of NF-kappa B in T-lymphocytes[J].Acta Pharmacol Sin,2000,21 (9):782.
[22]
吴柏林.雷公藤治疗类风湿性关节炎的机理探要[J].实用中医内科杂志,2003,17(3):150.
[23]
Asano K,Yu Y,Kasahara T,et al.Inhibition of murine chronic graft-versus-host disease by the chloroform extract of Tripterygium wilfordii Hook f.[J].Transpl Immunol,1997,5:315.
[24]
Qiu D,Kao P N.Immunosuppressive and anti-inflammatory mechanisms of triptolide,the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook f.[J].Drugs R D,2003,4:1.
Liu Q,Chen T,Chen H,et al.Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation[J].Biochem Biophys Res Commun,2004,319(3):980.
Krakauer T,Chen X,Howard O M,et al.Triptolide attenuates endotoxin-and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines[J].Immunopharmacol Immunotoxicol,2005,27 (1):53.
[30]
Yang Y,Liu Z,Tolosa E,et al.Triptolide induces apoptotic death of T lymphocyte[J].Immunopharmacology,1998,40(2):139.
Tao X L,Davis L S,Hashimoto K,et al.The Chinese herbal remedy,T2,inhibits mitogen-induced cytokine gene transcription by T cells,but not initial siginal transduction[J].J Pharmacol Exp Ther,1996,276:316.
[34]
Qiu D,Zhao G,Aoki Y,et al.Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation[J].J Biol Chem,1999,274(19):13443.
[35]
Chan M A,Kohlmeier J E,Branden M,et al.Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506[J].Phytother Res,1999,13:464.
Lai J H,Ho L J,Lu K C,et al.Western and Chinese antirheumatic drug-induced T cell apoptotic DNA damage uses different caspase cascades and is independent of Fas/Fas ligand interaction[J].J Immunol,2001,166(11):6914.
