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近10年中药与药物代谢酶相互作用的研究进展

Keywords: 中药,药物代谢,细胞色素P450

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Abstract:

药物之间的相互作用主要由细胞色素P450酶系(CYP)介导,CYP参与了绝大多数内源性和外源性分子的生物代谢过程,尤其是对药物的代谢。研究中药对CYP酶系的影响对保证临床药物作用的安全性和有效性具有极其重要的意义。本文综述近10年来中药与CYP作用的研究进展。

References

[1]  Guengerich F P. Cytochrome P450 3A4: regulation and role in drug metabolism[J]. Annu Rev Pharmacol Toxicol, 1999, 39:1.
[2]  de Wildt S N, Kearns G L, Leeder J S, et al. Cytochrome P450 3A: ontogeny and drug disposition[J]. Clin Pharmacokinet, 1999, 37:485.
[3]  扈金萍,陈晖,李燕. 双环醇对大鼠CYP450同工酶及II相酶的影响[J]. 中国新药杂志,2009, 18(4):340.
[4]  Han E H, Kim H G, Im J H, et al. Up-regulation of CYP1A1 by rutaecarpine is dependent on aryl hydrocarbon receptor and calcium[J]. Toxicology, 2009, 266:38.
[5]  Don M J, Lewis D F V, Wang S Y, et al. Effect of structural modification on the inhibitory selectivity of rutaecarpine derivatives on human CYP1A1, CYP1A2, and CYP1B1[J]. Bioorg Med Chem Lett, 2003, 13:2535.
[6]  Chatterjee P, Franklin M R. Human cytochrome P450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components [J]. Drug Metab Dispos, 2003, 31(11):1391.
[7]  Henderson G L, Harkey M R, Gershwin M E, et al. Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity [J]. Life Sci, 1999, 65:209.
[8]  孙坤,张爱平,王锐利,等. 荧光光谱法研究青蒿素类抗疟药与CYP2B6 酶的相互作用[J]. 分析测试学报,2011, 30(7):750.
[9]  von Mohke L L, Weemhoff J L, Bedir E, et al. Inhibition of human cytochromes P450 by components of Ginkgo biloba [J]. J Pharm Pharmacol, 2004, 56(8):1039.
[10]  Chang T K, Chen J, Teng X W. Distinct role of bilobalide and ginkgolide A in the modulation of rat CYP2B1 and CYP3A23 gene expression by Ginkgo biloba extract in cultured Hepatocytes [J]. Drug Metab Dispos, 2006, 34(2):234.
[11]  董宇,王阶,杨庆,等. CYP450 酶与中药代谢相互作用关系研究概况[J]. 中国中医药信息杂志,2011, 18(1):100.
[12]  周常,房文红,杨先乐,等. 五种中药提取物对拟穴青蟹肝微粒体CYP1A的抑制作用[J]. 海洋渔业,2011, 33(2):195.
[13]  张韬,彭华毅,刘洪旭,等. 银杏叶提取物及其不同成分对CYP3A4活性的影响[J]. 中国新药杂志,2011, 20(9):809.
[14]  Doehmer J, Weiss G, McGregor G P, et al. Assessment of a dry extract from milk thistle (Silybum marianum) for interference with human liver cytochrome-P450 activities[J]. Toxicol In Vitro, 2011, 25(1):21.
[15]  卜明华,郑咏秋,张颖,等. 心血管药物速效救心丸和通心络胶囊对大鼠细胞色素P450 酶的影响[J]. 中国临床药理学与治疗学,2011, 16(6):601.
[16]  韩晓文,李芹,阎静,等.注射用灯盏花素对大鼠CYP2D6体内代谢活性的影响[J].中国药房,2011,22(7):584.
[17]  许黎君,居文政,陈为烤,等.灯盏细辛注射液对小鼠肝微粒体细胞色素P450含量的影响[J]. 中国临床药理学与治疗学,2008,13(10):1122.
[18]  Zhou S F, Koh H L, Gao Y H, et al. Herbal bioactivation: the good, the bad and the ugly[J]. Life Sci, 2004, 74:935.
[19]  Shimada T, Yamazaki H, Mimura, et at, Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians[J]. J Pharmacol Exp Ther, 1994, 270:414.
[20]  Kolars J C, Lown K S, Schmiedlin-Ren P, et al. CYP3A gene expression in human gut epithelium[J]. Pharmacogenetics, 1994, 4:247.
[21]  Tassaneeyakul W, Guo L Q, Fukuda K, et al. Inhibition selectivity of grape fruit juice components on human cytochromes P450 [J]. Arch Biochem Biophys, 2000, 378(2):356.
[22]  Kimura Y, Ito H, Ohnishi R, et al. Inhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activity [J]. Food Chem Toxicol, 2010, 48:429.
[23]  李超. 五种6,7-呋喃香豆素对大鼠肝微粒体细胞色素P4501A2和2E1活性的影响. 泰安:泰山医学院, 2009.
[24]  Wen Y H, Sahi J, Urda E, et al. Effects of bergamottin on human and monkey drug-metabolizing enzymes in primary cultured hepatocytes [J]. Drug Metab Dispos, 2002, 30(9):977.
[25]  Takeuchi H, Saoo K, Yokohira M, et al. Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice [J]. Cancer Res, 2003, 63(22):7581.
[26]  Yano J K, Hsu M H, Griffin K J, et al. Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen[J]. Nat Struct Mol Biol, 2005, 12(9):822.
[27]  肖昌琼,周宏灏.金雀异黄酮在体内对CYP3A活性的影响[J].中国临床药理学与治疗学,2011,16(6):643.
[28]  Chan H Y, Leung L K. A potential protective mechanism of soya isoflavones against 7,12-dimethylbenz anthracene tumour initiation[J]. Br J Nutr, 2003, 90(2):457.
[29]  Henderson M C, Miranda C L, Stevens J F, et al. In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, humulus lupulus[J]. Xenobiotica, 2000, 30(3):235.
[30]  Schwarz D, Kisselev P, Roots I. CYP1A1 genotype-selective inhibition of benzo pyrene activation by quercetin[J]. Eur J Cancer, 2005, 41:151.
[31]  Doostdar H, Burke M D, Mayer R T. Bioflavonoids: selective substrates and inhibitors for cytochrome P450 CYP1A and CYP1B1 [J]. Toxicol, 2000, 144(1/3):31.
[32]  Walle T, Walle U K. Novel methoxylated flavone inhibitors of cytochrome P450 1B1 in SCC-9 human oral cancer cells [J]. J Pharm Pharmacol, 2007, 59(6):857.
[33]  Wen X, Walle U K, Walle T. 5,7-Dimethoxyflavone down regulates CYP1A1 expression and benzo pyrene-induced DNA binding in HepG2 cells[J]. Carcinogenesis, 2005, 26(4):803.
[34]  Ho P C, Saville D J, Wanwimolruk S. Inhibition of human CYP3A4 activity by grape fruit flavonoids, furanocoumarins and related compounds[J]. J Pharm Pharm Sci, 2001, 4(3):217.
[35]  Breinholt V M, Rasmussen S E, Brsen K, et al. In vitro metabolism of genistein and tangeretin by human and murine cytochrome P450s[J]. Pharmacol Toxicol, 2003, 93(1):14.
[36]  Backman J T, Menp J, Belle D J, et al. Lack of correlation between in vitro and in vivo studies on the effects of tangeretin and tangerine juice on midazolam hydroxylation [J]. Clin Pharmacol Ther, 2000, 67(4):382.
[37]  Pouget C, Fagnere C, Basly J P, et al. Synthesis and aromatase inhibitory activity of flavanones [J]. Pharm Res, 2002, 19(3):286.
[38]  Ta N, Walle T. Aromatase inhibition by bioavailable methylated flavones [J]. J Steroid Biochem Mol Biol, 2007, 107(1/2):127.
[39]  郭颖杰,康治臣,张家剑,等. 黄酮与黄酮醇类化合物对HepG2细胞中CYP1A1 mRNA表达的影响[J]. 中国实验诊学, 2008, 12(8):952.
[40]  侯艳宁,程桂芳,朱秀媛. 黄芩苷对小鼠肝细胞色素P450的选择性诱导[J]. 药学学报,2000, 35(12):890.
[41]  Androutsopoulos V P, Papakyriakou A, Vourloumis D, et al. Dietary flavonoids in cancer therapy and prevention: substrates and inhibitors of cytochrome P450 CYP1 enzymes [J]. Pharmacol Ther, 2010, 126:9.
[42]  Simanek V, Walterova D, Vicar J, et al. Silymarin-an extract from the milk thistle (Silybum marianum)-is it a drug or nutritional supplement? [J]. Ceska Slov Farm, 2001, 50(2):66.
[43]  Zuber R, Modriansk M, Dvork Z, et al. Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities [J]. Phytother Res, 2002, 16(7):632.
[44]  Chang T K, Lee W B, Ko H H. Trans-resveratrol modulates the catalytic activity and mRNA expression of the procarcinogenactivating human cytochrome P450 1B1 [J]. Can J Physiol Pharmacol, 2000, 78:874.
[45]  Chun Y J, Ryu S Y, Jeong T C, et al. Mechanism based inhibition of human cytochrome P450 1A1 by rhapontigenin [J]. Drug Metab Dispos, 2001, 29:389.
[46]  郭海方,邹晓丽,许卉,等. 丹参酚酸A对大鼠肝微粒体细胞色素P450酶系的影响 [J]. 中国中药杂志, 2010, 35(3):348.
[47]  张文静,曹琦琛,曹珂,等. 丹酚酸B的药动学研究进展[J]. 中国新药杂志,2011, 20(7):608.
[48]  朱根华,梁新丽,廖正根,等. 延胡索乙素及延胡索提取物在大鼠肝微粒体内代谢动力学研究[J]. 中药药理与临床,2009, 25(6):30.
[49]  赵鸣,李丽萍,沈剑,等. 延胡索乙素对映体对小鼠CYP450酶诱导和抑制作用研究[J]. 浙江大学学报:医学版,2011, 40(1):33.
[50]  Lee S K, Kim N H, Lee J, et al. Induction of cytochrome P450 by Rut and metabolism of Rut by cytochrome P450 [J]. Planta Med, 2004, 70(6):753.
[51]  Ueng Y F, Don M J, Jan W C, et al. Oxidative metabolism of the alkaloid rutaecarpine by human cytochrome P450 [J]. Drug Metab Dispos, 2006, 12(5):598.
[52]  徐斌,赵刚,位华,等. 20味中成药对5个人肝微粒体酶活性的影响[J]. 药学实践杂志, 2009, 27(5):353.
[53]  韩永龙,余奇,孟祥乐,等.灯盏细辛注射液对大鼠肝微粒体CYP3A的抑制作用[J]. 中国临床药理学与治疗学,2009,14(8):891.
[54]  韩永龙,孟祥乐,李丹,等. 清开灵注射剂等5种中药注射剂对大鼠肝微粒体CYP3A的体外抑制作用[J]. 中国中药杂志,2011, 36(4):492.
[55]  陈宏超.银杏叶提取物对细胞色素P4502E1表达的抑制作用. 郑州: 郑州大学,2007.
[56]  Xia C H, Sun J G, Wang G J, et al. Herb-drug interactions: in vivo and in vitro effect of shenmai injection, a herbal preparation, on the metabolic activities of hepatic cytochrome P450 3A1/2, 2C6, 1A2, and 2E1 in rats[J]. Planta Med, 2010, 76(3):245.
[57]  刘艳,王晶,鲍岩岩,等.清开灵注射液对大鼠CYP1A2和2D6的影响[J]. 中国中药杂志,2007,32(19):2044.
[58]  石杰,陈安进,张芳,等.血塞通及川芎嗪对细胞色素P450不同亚型代谢酶影响的研究[J]. 中国中西医结合急救杂志,2008,15(6):342.
[59]  刘史佳,居文政,陈为烤,等.血栓通注射液对大鼠体内细胞色素P450酶活性的影响[J].中国药学杂志,2010,45(2):115.
[60]  李晓宇,刘皋林,周佳纯,等.三七总苷注射液对大鼠肝CYP 酶的影响[J]. 中国临床药理学与治疗学,2009,14(8):849.
[61]  王启斌,狄伟,程晓莉,等.葛根素对细胞色素P450酶活性的影响[J]. 医药导报,2008,27(5):500.
[62]  陈为烤,居文政,许黎君,等.脉络宁注射液对小鼠肝药酶活性的影响[J]. 药学与临床研究,2008,16(5):351.
[63]  陈为烤,居文政,徐黎君,等.Cocktail 法研究脉络宁注射液对大鼠CYP1A2、CYP2E1 和CYP3A4 活性的影响[J]. 中国临床药理学与治疗学,2009,14(4):386.
[64]  舒焱,程泽能,刘昭前,等. 中国人肝微粒体中细胞色素P450酶含量和活性的个体间差异[J]. 中国药理学报,2001, 22(3):283.

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