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以烟酰胺为配体的NAMI衍生物的水解性质和溶液稳定性研究

Keywords: 钌化合物,烟酰胺,抗转移,水解动力学,稳定性

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Abstract:

目的:研究配体结构对NAMI衍生物的水解、溶液稳定性的影响。方法:制备了化合物1trans-Na·2DMSO(nica,nicotinamide烟酰胺);用紫外分光光度法研究了化合物1的水解机制,动力学及溶液稳定性。结果:与NAMI相似,化合物1在pH7.40的缓冲液中发生2步脱氯水解反应(Ⅰ氯水解及Ⅱ氯水解);在pH5.00缓冲液中二甲基亚砜(DMSO)水解。测定了各水解反应表观速率常数、半衰期及溶液稳定性参数。结论:化合物1在酸性溶液中的稳定性明显高于中性溶液。用烟酰胺取代咪唑环能够明显减慢NAMI衍生物的脱氯水解反应速度,但对脱DMSO水解反应影响较小。

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