全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用：99美元
投递稿件

查看量下载量

相关文章

更多...

灵芝三萜类化合物的研究进展

Keywords: 灵芝,三萜类化合物,提取纯化,含量分析

Full-Text   Cite this paper   Add to My Lib

Abstract:

作者综述了近年来国内外有关灵芝三萜类化合物的提取纯化工艺、化学成分及含量分析的研究现状及进展。灵芝三萜类化合物是灵芝中一种重要的药用活性成分,但是由于它在灵芝中的含量低,提取和纯化工艺复杂,目前高纯度的灵芝三萜化合物的制备量小,依然处在实验室的研究规模,因此,该文进一步探讨了制备灵芝三萜类化合物的产业化技术,旨在进一步推动灵芝产业的快速发展,为其作为保健食品、药品的研究和生产提供科学依据。

 References

[1]  黄艳娟, 肖桂林. 灵芝三萜药理学作用研究进展[J]. 中医药导报, 2008, 14(9):87.
[2]  Liu J, Kuniyoshi Shimizu, Fumiko Konishi, et al. Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum [J]. Food Chem, 2007, 100:1691.
[3]  Pillai T G, Bincy C P, Janardhanan K K. Anti-oxidant activity of triterpenes isolated from Ganoderma lucidum [J]. Amala Res Bull, 2004, 24:185.
[4]  Huang S M, Yang X L, Wang B W, et al. Anti-tumor activity of ethanol-soluble and acidic components from Ganoderma lucidum [J]. Nat Prod Res Dev, 2004, 16:146.
[5]  Min B S, Gao J J, Hattori M, et al. Anti-complement activity of terpenoids from the spores of Ganoderma lucidum [J]. Planta Med, 2001, 67:811.
[6]  Min B S, Gao J J, Nakamura N, et al. Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells[J]. Chem Pharm Bull, 2000, 48:1026.
[7]  Li P Z, Zhang K C. Isolation, purification, and antimicrobial activity of ganoderic acids M1-M3 from the fermented mycelia of Ganoderma lucidum[J]. Nat Prod Res Dev, 1999, 11:67.
[8]  罗俊, 林志彬. 灵芝三萜类化合物药理作用研究进展[J]. 药学学报, 2002, 37(7):574.
[9]  林志彬. 灵芝的现代研究[M]. 3版.北京, 北京大学医学出版社, 2007.
[10]  侯敏娜,刘剑.灵芝三萜的提取分离及总三萜的含量测定[J].现代中药研究与实践,2010,24(5):70.
[11]  Iksoo Lee, Jungju Seo, Jinpyo Kim, et al. Lanostane triterpenes from the fruiting bodies of Ganoderma lucidum and their inhibitory effects on adipocyte differentiation in 3T3-L1 Cells[J]. J Nat Prod, 2010, 73:172.
[12]  Wang X M, Yang M, Guan S H, et al. Quantitative determination of six major triterpenoids in Ganoderma lucidum and related species by high performance liquid chromatography [J]. Pharm Biomed Anal, 2006, 41:838.
[13]  Sri Fatmawati, Kuniyoshi Shimizu, Ryuichiro Kondo. Ganoderic acid Df, a new triterpenoid with aldose reductase inhibitory activity from the fruiting body of Ganoderma lucidum[J]. Fitoterapia, 2010, 81:1033.
[14]  张志军, 朱越, 罗莹, 等. 灵芝中三萜类化合物提取工艺[J]. 食品研究与开发, 2009, 30(9):81.
[15]  张亮, 程-伦, 孙春玉, 等. 灵芝主要有效成分超声提取工艺的优化[J]. 北华大学学报, 2010, 11(2):140.
[16]  Liu Y L, Liu Y P, Qiu F, et al. Sensitive and selective liquid chromatography-tandem mass spectrometry method for the determination of five ganoderic acids in Ganoderma lucidum and its related species[J]. Pharm Biomed Anal, 2011, 54:717.
[17]  蒉霄云, 何晋浙, 王静, 等. 微波提取灵芝中三萜类化合物的研究 [J]. 中国食品学报, 2010, 10(2):89.
[18]  Chen Y, Xie M Y, Gong X F. Microwave-assisted extraction used for the isolation of total triterpenoid saponins from Ganoderma atrum[J]. J Food Eng, 2007, 81:162.
[19]  韩布兴. 超临界流体与技术[M]. 北京:中国石化出版社, 2010:8.
[20]  廖传华, 史勇春. 超临界流体与中药制备[M]. 北京:中国石化出版社, 2007:1.
[21]  宋师花, 贾晓斌, 陈彦, 等. 超临界CO2萃取灵芝子实体中的三萜类成分[J]. 中国中药杂志,2008, 33(17):2104.
[22]  张洁, 段继诚, 梁振, 等. 超临界流体萃取-高效液相色谱离线联用分析灵芝中三萜类化合物[J]. 分析化学, 2006, 34(4):447.
[23]  陈燕, 柳正良, 陈志东, 等. 优选超临界CO2萃取灵芝孢子粉中总三萜化合物的最佳工艺[J]. 药学服务与研究, 2010, 10(1):34.
[24]  贾晓斌, 宋师花, 陈彦, 等. 超临界CO2萃取法和醇回流法提取灵芝中三萜类成分的比较[J]. 中成药, 2010, 32(5):868.
[25]  Rueychi Hsu, Binhwae Lin, Chiwei Chen. The study of supercritical carbon dioxide extraction for Ganoderma Lucidum[J]. Ind Eng Chem Res,2001, 40:4478.
[26]  廖幼鸣, 姚渭溪, 赵颖涛, 等. 一种从灵芝中制备灵芝三萜酸和灵芝多糖的方法:200410005571 . 2005-01-05
[27]  钱律余. 全灵芝孢子中有效成分的超临界CO2萃取方法:中国,200410017468 . 2005-01-12.
[28]  弓晓峰, 谢明勇, 陈奕. 黑灵芝中三萜及其皂苷类化合物总量的光度测定[J]. 天然产物研究与开发, 2006, 18(5):825.
[29]  Somayeh Keypour, Hasan Rafati, Hossain Riahi, et al. Qualitative analysis of ganoderic acids in Ganoderma lucidum from Iran and China by RP-HPLC and electrospray ionisation-mass spectro- metry(ESI-MS) [J]. Food Chem, 2010, 119:1704.
[30]  中国药典. 一部[S]. 2010:174.
[31]  Xu J W, Zhao W, Zhong J J. Biotechnological production and application of ganoderic acids[J]. Appl Microbiol Biotechnol, 2010, 87:57.
[32]  Li Y Q, Wang S F. Antihepatitis B activities of ganoderic acid from Ganoderma lucidum[J]. Biotechnol Lett, 2006, 28:837.
[33]  Ko H H, Hung C F, Wang J P, et al. Antiinflammatory triterpenoids and steroids from Ganoderma lucidum and G. tsugae[J]. Phytochem Anal,2008, 69(1):234.
[34]  Li C, Li Y, Sun H H. New ganoderic acids, bioactive triterpenoid metabolites from the mushroom Ganoderma lucidum [J]. Nat Prod Res, 2006, 20(11):985.
[35]  Chen M, Zhang M, Sun S, et al. A new triterpene from the fruiting bodies of Ganoderma lucidum[J]. Acta Pharm Sin, 2009, 44(7):768.
[36]  陈若芸, 于德泉. 赤芝孢子粉三萜化学成分研究[J]. 药学学报, 1991, 26(4):267.
[37]  Cheng C R, Yue Q X, Wu Z Y, et al. Cytotoxic triterpenoids from Ganoderma lucidum[J]. Phytochem Anal, 2010, 71:1579.
[38]  Liu J, Kenji Kurashiki, Kuniyoshi Shimizu, et al. Structure-activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidum[J]. Bioorg Med Chem,2006, 14:8654.
[39]  Toshihiro Akihisa, Masaaki Tagata, Motohiko Ukiya, et al. Oxygenated lanostane-type triterpenoids from the fungus Ganoderma lucidum[J]. J Nat Prod, 2005, 68:559.
[40]  钱竹, 徐鹏, 章克昌, 等. 大孔树脂分离提取发酵液中灵芝三萜类物质[J]. 食品与生物技术学报, 2006, 25(6):111.
[41]  Ma J Y, Ye Q, Hua Y J, et al. New lanostanoids from the mushroom Ganoderma lucidum[J]. J Nat Prod, 2002, 65:72.
[42]  Yoshiyuki Mizushina, Naoko Takahashi, Linda Hanashima, et al. Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, Ganoderma lucidum[J]. Bioorg Med Chem, 1999, 7:2047.
[43]  Tianshung Wu, Lishian Shi, Shengchu Kuo. Cytotoxicity of Ganoderma lucidum triterpenes[J]. J Nat Prod, 2001, 64:1121.
[44]  Gao J J, Byung-Sun Min, Eun-Mi Ahn, et al. New triterpene aldehydes, lucialdehydes A-C, from Ganoderma lucidum and their cytotoxicity against murine and human tumor cells[J]. Chem Pharm Bull, 2002, 50(6):837.
[45]  Kenji Iwatsuki, Toshihiro Akihisa, Harukuni Tokuda. Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on epstein- barr virus activation[J]. J Nat Prod, 2003, 66:1582.
[46]  Hueyjen Su, Yihfen Fann, Meiing Chung, et al. New lanostanoids of Ganoderma tsugae[J]. J Nat Prod, 2000, 63:514.
[47]  Peter Kleinwa Chter, Ngo Anh, Trinh Tam Kiet, et al. Colossolactones, new triterpenoid metabolites from a vietnamese mushroom Ganoderma colossum [J]. J Nat Prod, 2001, 64:236.
[48]  Liu J, Kuniyoshi Shimizu, Fumiko Konishi, et al. Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum[J]. Food Chem, 2007, 100:1691.
[49]  王江海, 袁建平, 徐世平, 等. 薄层色谱光度法测定灵芝孢子油中的总三萜含量[J]. 中国食品学报, 2004, 4(3):76.
[50]  Ching Hua Su, Yi Zhen Yang, Hsiu O Ho, et al. High performance liquid chormatographic analysis for the characterization of triterpenoids from Ganoderma[J]. J Chromatogr Sci, 2001, 39(3):93.
[51]  李保明, 刘超, 陈若芸, 等. 灵芝总三萜酸含量测定方法的研究[J]. 中国中药杂志, 2007, 32(12):1234.
[52]  杨军, 余德顺, 罗俊, 等. 超临界二氧化碳萃取灵芝总三萜的工艺研究[J]. 时珍国医国药, 2008, 19(3):539.
[53]  Naoto Sato, Ma C M, Katsuko Komatsu, et al. Triterpene-farnesyl hydroquinone conjugates from Ganoderma sinense[J]. J Nat Prod, 2009, 72:958.
[54]  李保明, 刘超, 陈若芸, 等. 赤芝中三萜酸HPLC特征图谱的研究[J]. 药物分析杂志, 2009, 29(9):1514.
[55]  丁平,梁英娇,罗进辉,等.灵芝中主要六种三萜酸类成分的HPLC定量分析[J].中国药学杂志,2009,44(11):822.
[56]  Yang M, Wang X M, Guan S H, et al. Analysis of triterpenoids in Ganoderma lucidum using liquid chromatography coupled with electrospray ionization mass spectrometry[J]. J Am Soc Mass Spectrom, 2007, 18:927.
[57]  Gao J J, Norio Nakamura, Byung-Sun Min, et al. Quantitative determination of bitter principles in sepcimens of Ganiderma lucidum using high performance liquid chromatography and its application to the evaluation of Ganoderma Products[J]. Chem Pharm Bull, 2004, 52(6):688.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133